Results 71 to 80 of about 8,213 (177)
Pathogenic Gαo Mutants Drive Dominant GPCR Coupling in GNAO1 Encephalopathies
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.Mutations in GNAO1, the gene encoding Gαo, are associated with a wide range of neurodevelopmental disorders. In this study, we show that Gαo variants linked to the most severe patient phenotypes fail to disengage from activated Gi/o‐coupled GPCRs, thereby blocking GRK‐mediated receptor phosphorylation and internalization.
Yonika A. Larasati +4 more
wiley +1 more source
Arthritis Care &Research, Volume 78, Issue 1, Page 106-112, January 2026.Objective There are no US Food and Drug Administration–approved therapies for Raynaud phenomenon (RP) in the United States. Clinical trials have been challenged by study design. Important advances in RP patient‐reported outcome measures and mechanistic quantification allow RP‐related pain characterization.
Tracy M. Frech +4 more
wiley +1 more source
Journal of Pharmacological Sciences, 2005 Neurotropin®, a non-protein extract from the inflamed skin of rabbits inoculated with vaccinia virus, has been clinically used as an analgesic drug for treatment of chronic pain.
Tomoshi Miura +5 more
doaj +1 more source
Animal models of attention-deficit hyperactivity disorder [PDF]
, 2005 Although animals cannot be used to study complex human behaviour such as language, they do have similar basic functions. In fact, human disorders that have animal models are better understood than disorders that do not.
Borgå Johansen, Espen +2 more
core +2 more sources
Food Frontiers, Volume 7, Issue 1, January 2026.The presented review provides the potential antihypertensive benefits of traditionally employed edible seeds, presenting new perspectives and avenues for future research. ABSTRACT Hypertension, often referred to as a silent killer, is responsible for 7.5 million deaths, representing approximately 12.8% of all global mortality.
Jinmin Shi +8 more
wiley +1 more source
Efficacy of Different Antiemetics with Different Mechanism of Action on Xylazine Induced Emesis in Cats [PDF]
Iranian Journal of Veterinary Surgery, 2014 Xylazine hydrochloride, α2 adrenoceptor agonist, is an analgesic, sedative, tranquilizer, and muscle relaxant agent in veterinary medicine which is mostly used as in pre-anesthesia in veterinary medicine. One of the main adverse effects of xylazine which
Saeed Kolahian
doaj
Journal of Pharmacological Sciences, 2012 Microinjection of the α2-adrenoceptor agonist clonidine into the hypothalamic periventricular nuclei (PVN) induces the pressor response associated with bradycardia in freely-moving conscious rats. This study investigated the involvement of γ-aminobutyric
Nobuyuki Hanafusa +3 more
doaj +1 more source
Exploring Autophagy Inducing Molecules: Targeting Diverse Pathways in Alzheimer's Disease Management
Medicinal Research Reviews, Volume 46, Issue 1, Page 272-298, January 2026.ABSTRACT Neurodegenerative disorders, including Alzheimer's disease (AD), impose a significant burden on society due to their progressive nature and the associated healthcare costs. Autophagy, a vital cellular degradation process, has emerged as a promising therapeutic target in these disorders.
Baljinder Singh +4 more
wiley +1 more source
The α2-Adrenoceptor Agonist Dexmedetomidine in Current Sedation Practice
Общая реаниматология, 2013 The problem of sedation in intensive care units has obvious scientific-and-practical relevance. Many current studies deal with the practical introduction of novel medications for sedation, with the specific features of their pharmacodynamic effects in ...
I. A. Kozlov
doaj +1 more source
The effects of different concentrations of the α2-Adrenoceptor Agonist Medetomidine on basal excitatory synaptic transmission and synaptic plasticity in hippocampal slices of adult mice [PDF]
, 2015 α2-Adrenoceptor agonists are used frequently in human and veterinary anesthesia as sedative/analgesic drugs. However, they can impair cognition. Little is known about the concentration-dependent effects of α2-adrenoceptor agonists on synaptic plasticity,
Antunes, Luis M. +5 more
core +1 more source