Neuronal nicotinic acetylcholine receptor antibodies in autoimmune central nervous system disorders
Frontiers in ImmunologyBackgroundNeuronal nicotinic acetylcholine receptors (nAChRs) are abundant in the central nervous system (CNS), playing critical roles in brain function. Antigenicity of nAChRs has been well demonstrated with antibodies to ganglionic AChR subtypes (i.e.,
Maria Pechlivanidou +29 more
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Effect of miRNA-138 Injected into the Medial Habenula on Nicotine Intake and Preference [PDF]
, 2015 Nicotine is one of the most commonly abused drugs in the world today and is associated with many adverse health outcomes, including death. Nicotine binds to nicotinic acetylcholine receptors (nAChRs) in the brain reward pathway, triggering the release of
Fitzgerald, Kelsey
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Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]Octanes As Selective α4β2-Nachr Ligands [PDF]
, 2014 We report the synthesis and characterization of a series of enantiopure 5-cyclopropane-bearing pyridyldiazabicyclo[3.3.0]octanes that display low nanomolar binding affinities and act as functional agonists at α4β2-nicotinic acetylcholine receptor ...
Brunner, Dani +6 more
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Y-aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic a-conotoxins [PDF]
, 2012 Background: A class of analgesic a-conotoxins potently inhibits N-type calcium channels. Results: The activity of a-conotoxins Vc1.1 and RgIA was reduced following knockdown of GABAB receptor expression in sensory neurons and can be reconstituted in ...
Adams, DJ +5 more
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Design, Synthesis, and Biological Activity of 5\u27-Phenyl-1,2,5,6-tetrahydro-3,3\u27-bipyridine Analogues as Potential Antagonists of Nicotinic Acetylcholine Receptors [PDF]
, 2017 Starting from a known non-specific agonist (1) of nicotinic acetylcholine receptors (nAChRs), rationally guided structural-based design resulted in the discovery of a small series of 5′-phenyl-1,2,5,6-tetrahydro-3,3′-bipyridines (3a – 3e) incorporating a
Huang, Xiaoqin +5 more
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, 2011 dissertationDorsal root ganglia (DRG) contain neurons whose axons convey somatosensory information, including pain, from the periphery to the central nervous system (CNS). These neurons are known to express a variety of nicotinic acetylcholine receptors (
Hone, John Charles
core
Nicotinic Signaling: Alpha3 Beta4 Heteromers, Alpha5 Subunits, And The Prototoxin Lypd6b [PDF]
, 2015 Prototoxin proteins have been identified as members of the Ly6/uPAR super family whose three-finger motif resembles that of α-bungarotoxin. Though they are known to modify the function of nAChRs, their specificity is still unclear.
Ochoa, Vanessa
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AT-1001: a high-affinity α3β4 nAChR ligand with novel nicotine-suppressive pharmacology. [PDF]
Br J Pharmacol, 2015 Cippitelli A +13 more
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The α3β4 nAChR partial agonist AT-1001 attenuates stress-induced reinstatement of nicotine seeking in a rat model of relapse and induces minimal withdrawal in dependent rats. [PDF]
Behav Brain Res, 2017 Yuan M +5 more
europepmc +1 more source
Pharmacological stress is required for the anti-alcohol effect of the α3β4* nAChR partial agonist AT-1001. [PDF]
Neuropharmacology, 2015 Cippitelli A +4 more
europepmc +1 more source