Habenular expression of rare missense variants of the β4 nicotinic receptor subunit alters nicotine consumption [PDF]
Frontiers in Human Neuroscience, 2014 The CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3 and β4 nicotinic acetylcholine receptor (nAChR) subunits, has been linked to nicotine dependence. The habenulo-interpeduncular (Hb-IPN) tract is particularly enriched in α3β4 nAChRs.
Marta A Ślimak +9 more
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SR9883 is a novel small-molecule enhancer of α4β2* nicotinic acetylcholine receptor signaling that decreases intravenous nicotine self-administration in rats [PDF]
Frontiers in Molecular NeuroscienceBackgroundMost smokers attempting to quit will quickly relapse to tobacco use even when treated with the most efficacious smoking cessation agents currently available.
Kevin M. Braunscheidel +12 more
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Using Constellation Pharmacology to Characterize a Novel α-Conotoxin from Conus ateralbus [PDF]
Marine DrugsThe venom of cone snails has been proven to be a rich source of bioactive peptides that target a variety of ion channels and receptors. α-Conotoxins (αCtx) interact with nicotinic acetylcholine receptors (nAChRs) and are powerful tools for investigating ...
Jorge L. B. Neves +19 more
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Nicotinic Receptors in Human Chromaffin Cells: Characterization, Functional and Physical Interactions between Subtypes and Regulation. [PDF]
Int J Mol SciThis review summarizes our research on nicotinic acetylcholine receptors in human chromaffin cells. Limited research has been conducted in this field on human tissue, primarily due to the difficulties associated with obtaining human cells.
Jiménez-Pompa A, Albillos A.
europepmc +3 more sources
Marine Drugs, 2022 α6β4 nAChR is expressed in the peripheral and central nervous systems and is associated with pain, addiction, and movement disorders. Natural α-conotoxins (α-CTxs) can effectively block different nAChR subtypes with higher efficacy and selectivity ...
Liujun Wang +5 more
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Marine Drugs, 2022 Neuronal nicotinic acetylcholine receptors (nAChRs) are important ion channel membrane proteins that are widely distributed in the central nervous system (CNS) and peripheral nervous system (PNS).
Meiling Huang +5 more
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Cell surface localization of α3β4 nicotinic acetylcholine receptors is regulated by N-cadherin homotypic binding and actomyosin contractility. [PDF]
PLoS ONE, 2013 Neuronal nicotinic acetylcholine receptors (nAChRs) are widely expressed throughout the central and peripheral nervous system and are localized at synaptic and extrasynaptic sites of the cell membrane.
Juan L Brusés
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Marine Drugs, 2021 Nicotinic acetylcholine receptor (nAChR) subtypes are key drug targets, but it is challenging to pharmacologically differentiate between them because of their highly similar sequence identities.
Dana Katz +5 more
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Molecular docking study on the α3β2 neuronal nicotinic acetylcholine receptor complexed with α-Conotoxin GIC [PDF]
BMB Reports, 2012 Nicotinic acetylcholine receptors (nAChRs) are a diverse familyof homo- or heteropentameric ligand-gated ion channels.Understanding the physiological role of each nAChR subtypeand the key residues responsible for normal and pathologicalstates is ...
Chewook Lee +3 more
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Marine Drugs, 2022 Conopeptides are peptides in the venom of marine cone snails that are used for capturing prey or as a defense against predators. A new cysteine-poor conopeptide, Czon1107, has exhibited non-competitive inhibition with an undefined allosteric mechanism in
Yuan Ma +9 more
doaj +1 more source