Results 51 to 60 of about 2,175 (165)

Loop2 Size Modification Reveals Significant Impacts on the Potency of α-Conotoxin TxID

Marine Drugs, 2023
α4/6-conotoxin TxID, which was identified from Conus textile, simultaneously blocks rat (r) α3β4 and rα6/α3β4 nicotinic acetylcholine receptors (nAChRs) with IC50 values of 3.6 nM and 33.9 nM, respectively.
Jianying Dong, Panpan Zhang, Junjie Xie, Ting Xie, Xiaopeng Zhu, Dongting Zhangsun, Jinpeng Yu, Sulan Luo   +7 more
doaj   +1 more source

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

Marine Drugs, 2015
In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH2), which was previously identified by cDNA libraries from Conus marmoreus in our lab.
Shuo Wang, Cong Zhao, Zhuguo Liu, Xuesong Wang, Na Liu, Weihong Du, Qiuyun Dai   +6 more
doaj   +1 more source

Wheel running during chronic nicotine exposure is protective against mecamylamine‐precipitated withdrawal and up‐regulates hippocampal α7 nACh receptors in mice [PDF]

, 2017
Background and purpose Evidence suggests that exercise decreases nicotine withdrawal symptoms in humans; however, the mechanisms mediating this effect are unclear.
Abrantes, al'Absi, Alexander, Alexander, Aydin, Baldwin, Balter, Barik, Berrendero, Breese, Brunzell, Castañé, Christensen, Cippitelli, Cosgrove, Curtis, Czubak, Dajas-Bailador, Damaj, Dubreucq, Erickson, Field, Fisher, Fuss, Georgiou, Haasova, Hadjiconstantinou, Hambsch, Harmey, Hasan, Ickes, Jackson, Jackson, Kenny, Kilkenny, Krishnan-Sarin, Li, Lifestyles Statistics Team, The Health and Social Care Information Centre, Malin, Marubio, Massey, Matta, McGinty, McGrath, Merrer, Metaxas, Miladi-Gorji, Mineur, Oliveira, Parrott, Picciotto, Picciotto, Rankin, Raybuck, Rueda, Salas, Salas, Sanchez, Scerbo, Scott, Simmons, Smith, Southan, Stoker, Strickland, Tapia-Arancibia, Taylor, Taylor, Thanos, Ussher, Vučcković, Walters, Wilkinson, Wright, Zanos, Zhou   +75 more
core   +1 more source

Characterisation of Elevenin-Vc1 from the Venom of Conus victoriae: A Structural Analogue of α-Conotoxins

Marine Drugs, 2023
Elevenins are peptides found in a range of organisms, including arthropods, annelids, nematodes, and molluscs. They consist of 17 to 19 amino acid residues with a single conserved disulfide bond.
Bankala Krishnarjuna, Punnepalli Sunanda, Jeffrey Seow, Han-Shen Tae, Samuel D. Robinson, Alessia Belgi, Andrea J. Robinson, Helena Safavi-Hemami, David J. Adams, Raymond S. Norton   +9 more
doaj   +1 more source

Varenicline decreases nicotine but not alcohol self-administration in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats [PDF]

, 2015
Background: Alcohol and nicotine are largely co-abused. Here, we investigated whether concurrent exposure to both addictive drugs influences each other's consumption and whether varenicline attenuates alcohol consumption in the presence of nicotine ...
Ciccocioppo, Roberto, Cippitelli, Andrea, Scuppa, Giulia, Toll, Lawrence, Ubaldi, Massimo   +4 more
core   +1 more source

Differentiating the Neuropharmacological Properties of Nicotinic Acetylcholine Receptor-Activating Alkaloids

Frontiers in Pharmacology, 2022
Alkaloids that target nicotinic acetylcholine receptors (nAChR) are of great interest because of the critical role they play in mood and anxiety. However, understanding of the neuropharmacological effects of nicotinic alkaloids, such as cotinine and ...
Omar Alijevic, Oihane Jaka, Ainhoa Alzualde, Diana Maradze, Wenhao Xia, Stefan Frentzel, Andrew N. Gifford, Manuel C. Peitsch, Julia Hoeng, Kyoko Koshibu   +9 more
doaj   +1 more source

1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties [PDF]

, 2016
Nicotine acethylcholine receptors (nAChRs) play critical roles in cognitive processes, neuroprotection and inflammation. Results: According to their substituents, 1,3-diphenylpropan-1-one derivatives act as α7 nAChRs negative allosteric modulators (NAM ...
Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Beatriz Balsera, Francisco Sala, José Mulet, Manuel Criado, Marta Miguel, María Jesús Pérez de Vega, Roberto de la Torre-Martínez, Rosario González-Muñiz, Salvador Sala, Silvia Moreno-Fernández   +11 more
core   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, Volume 46, Issue 1, Page 179-197, January 2026.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Probing Binding Interactions of Cytisine Derivatives to the α4β2 Nicotinic Acetylcholine Receptor [PDF]

, 2019
Nicotinic acetylcholine receptors (nAChRs) are crucial for communication between synapses in the central nervous system. As such, they are also implicated in several neuropsychiatric and addictive diseases.
Blom, Annet E. M., Dougherty, Dennis A., Gallagher, Timothy, Lester, Henry A., Rego Campello, Hugo   +4 more
core   +4 more sources