Results 71 to 80 of about 2,175 (165)

Nicotinic acetylcholine receptors modulate osteoclastogenesis [PDF]

, 2016
Background: Our aim was to investigate the role of nicotinic acetylcholine receptors (nAChRs) in in-vitro osteoclastogenesis and in in-vivo bone homeostasis.
A Bajayo, A Orr-Urtreger, A Yarilina, AJ Ewins, Attila Mócsai, CL Henemyre, David Győri, DE Rothem, Despoina Sykoutri, DK Williams, E Somm, EX Albuquerque, FC Macintosh, Gyula Poór, H Takayanagi, H Tanaka, H Tanaka, I Wessler, J Tam, JA Dani, Josef S. Smolen, K Kawashima, K Kliemann, K Redlich, KJ Tracey, KS Lips, Kurt Redlich, LM Koval, LM Walker, LZ Wu, M Artico, M Asagiri, M En-Nosse, M Kedmi, M Rosas-Ballina, MA Fang, MA Maanen van, MR McClung, MR Picciotto, O Herault, PC Staton, Peter Mandl, Petra Scholze, R Reitstetter, RL Papke, S Hayer, S Yuhara, SB Cohen, Sigismund Huck, Silvia Hayer, SJ Romano, Stephan Blüml, T Koga, T Negishi-Koga, T Sato, Thomas Karonitsch, V Itier, ZQ Wang   +57 more
core   +2 more sources

Cyclization of the Analgesic α‐Conotoxin Vc1.1 With a Non‐Natural Linker: Effects on Structure, Stability, and Bioactivity

Journal of Peptide Science, Volume 31, Issue 6, June 2025.
This study cyclized conotoxin Vc1.1 using polyethylene glycol (PEG) linkers of different lengths and demonstrates that linker length modulates the peptide's helicity, thereby influencing its biological activity and stability. ABSTRACT α‐Conotoxin Vc1.1 is a disulfide‐rich peptide and a promising drug candidate for treating neuropathic and chronic pain.
Yuhui Zhang, Han Shen Tae, David J. Adams, Thomas Durek, David J. Craik   +4 more
wiley   +1 more source

α7 Nicotinic acetylcholine receptor-specific antibody induces inflammation and amyloid β42 accumulation in the mouse brain to impair memory.

PLoS ONE, 2015
Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cognitive functions, as well as inflammatory reactions. Their density is decreased upon Alzheimer disease accompanied by accumulation of β-amyloid (Aβ42), memory
Olena Lykhmus, Larysa Voytenko, Lyudmyla Koval, Sergiy Mykhalskiy, Victor Kholin, Kateryna Peschana, Marios Zouridakis, Socrates Tzartos, Sergiy Komisarenko, Maryna Skok   +9 more
doaj   +1 more source

Rescue of amyloid-Beta-induced inhibition of nicotinic acetylcholine receptors by a peptide homologous to the nicotine binding domain of the alpha 7 subtype.

PLoS ONE, 2013
Alzheimer's disease (AD) is characterized by brain accumulation of the neurotoxic amyloid-β peptide (Aβ) and by loss of cholinergic neurons and nicotinic acetylcholine receptors (nAChRs).
Arthur A Nery, Margaret H Magdesian, Cleber A Trujillo, Luciana B Sathler, Maria A Juliano, Luiz Juliano, Henning Ulrich, Sergio T Ferreira   +7 more
doaj   +1 more source

Heterologous expression and nonsense suppression provide insights into agonist behavior at α6β2 nicotinic acetylcholine receptors [PDF]

, 2015
The α6-containing subtypes of the nicotinic acetylcholine receptor (nAChR) are localized to presynaptic terminals of the dopaminergic pathways of the central nervous system.
Dougherty, Dennis A., Lester, Henry A., Limapichat, Walrati, Post, Michael R.   +3 more
core   +1 more source

Impacts of perinatal nicotine exposure on nicotinic acetylcholine receptor expression and glutamatergic synaptic transmission in the mouse auditory brainstem

The Journal of Physiology, Volume 603, Issue 9, Page 2857-2876, 1 May 2025.
Abstract figure legend Developmental nicotine exposure is known to cause a myriad of health defects including auditory processing deficits. In human and animal studies, nicotine exposure can lead to impaired auditory temporal processing and disrupted glutamate synapse development within the auditory cortex.
Mackenna Wollet, Abram Hernandez, Kaila Nip, Brett Ginsburg, Jason R. Pugh, Jun Hee Kim   +5 more
wiley   +1 more source

Identification of Nicotinic Acetylcholine Receptor for N‐Acetylcysteine to Rescue Nicotine‐induced Injury Using Beating Cilia in Primary Tissue Derived Airway Organoids

Advanced Science, Volume 12, Issue 1, January 9, 2025.
Human primary tissue‐derived airway organoids can recapitulate the ciliary beating of the airway. The expression of nicotinic receptors in cilia plays a role in maintaining the ciliary beating. Nicotine decreases ciliary beating function by binding to the nicotinic receptors.
Yichao Zheng, Qinyong Tian, Haowei Yang, Yongde Cai, Jiaxin Zhang, Yifen Wu, Shuo Zhu, Zuocheng Qiu, Yimin Lin, Jiangquan Hong, Yi Zhang, David Dockrell, Shaohua Ma   +12 more
wiley   +1 more source

Mitochondrial Nicotinic Acetylcholine Receptors Support Liver Cells Viability After Partial Hepatectomy

Frontiers in Pharmacology, 2018
Nicotinic acetylcholine receptors (nAChRs) expressed on the cell plasma membrane are ligand-gated ion channels mediating fast synaptic transmission, regulating neurotransmitter and cytokine release and supporting the viability of many cell types.
Kateryna Uspenska, Olena Lykhmus, Maria Obolenskaya, Stephanie Pons, Uwe Maskos, Serhiy Komisarenko, Maryna Skok   +6 more
doaj   +1 more source

Prenatal cigarette smoke exposure effects on apoptotic and nicotinic acetylcholine receptor expression in the infant mouse brainstem [PDF]

, 2016
© 2015 Elsevier Inc. Infants exposed to cigarette smoked during pregnancy into infancy have increased respiratory and cardiac abnormalities. Nicotine, the major neurotoxic component of cigarette smoke, induces its actions by binding to nicotinic ...
Chan, YL, Chen, H, Machaalani, R, Vivekanandarajah, A   +3 more
core   +1 more source

The human‐specific nicotinic receptor subunit CHRFAM7A reduces α7 receptor function in human induced pluripotent stem cells‐derived and transgenic mouse neurons

European Journal of Neuroscience, Volume 60, Issue 5, Page 4893-4906, September 2024.
Abstract We investigated the impact of the human‐specific gene CHRFAM7A on the function of α7 nicotinic acetylcholine receptors (α7 nAChRs) in two different types of neurons: human‐induced pluripotent stem cell (hiPSC)‐derived cortical neurons, and superior cervical ganglion (SCG) neurons, taken from transgenic mice expressing CHRFAM7A. dupα7, the gene
Ilayda Görgülü, Vinita Jagannath, Stephanie Pons, Filip Koniuszewski, Matthias Groszer, Uwe Maskos, Sigismund Huck, Petra Scholze   +7 more
wiley   +1 more source