Results 81 to 90 of about 4,115 (172)

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source

β-Carbolines. 2. Rate Constants of Proton Transfer from Multiexponential Decays in the Lowest Singlet Excited State of Harmine in Water As a Function of pH [PDF]

, 1996
The β-carbolines present a complex problem involving multiple equilibria in the excited state in hydrogen-bonding solvents including water. Three excited state species exist: neutral, cation, and zwitterion.
Becker, R. S., Burrows, H. D., Dias, A., Maçanita, A. L., Miguel, M. da Graça, Varela, A. P.   +5 more
core   +1 more source

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

In vitro anti influenza virus activity, antioxidant potential and total phenolic content of twelve Iranian medicinal plants [PDF]

, 2017
The emergence of medicine resistance strains of influenza A viruses to the chemical drogs lead to the development of alternative herbal compounds that inhibit the virus replication. Therefore, the aim of this research was to investigate in vitro anti-
Alidadi, Somayeh., Karimi, Ali., Lorigooini, Zahra., Moradi, Mohammad-Taghi., Pourgheysari, Batoul.   +4 more
core   +1 more source

Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. [PDF]

, 2020
Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices ...
A Ashoor, A Kuryatov, A Loukola, A Loukola, A Markou, A Pandhare, AA George, AA Strasser, AB Tekinay, AC Harris, AC Villanti, AJ Lanca, AJ Law, AK Stoker, AR Tapper, AT Peana, B Forget, B Froeliger, B Le Foll, B Lenz, BJ Hall, BJ Henderson, CD Fowler, CD Fowler, CDC, CJ Livingston, CL Walters, CL Walters, CM Flores, D Bagdas, D Carmelli, D Gonzales, D Ji, D John, D Vullhorst, DB Vazquez-Sanroman, DC Perry, DK Williams, E Wada, EC Pittaras, ED Claus, EE DeVito, EJ Nestler, EN Lyukmanova, FI Carroll, FJ McClernon, G Di Chiara, G Kong, G Schoenbaum, GS Portugal, H Xian, HD Mansvelder, I Ibanez-Tallon, J Hartmann-Boyce, J Hartmann-Boyce, J Ramirez-Latorre, J Tang, JA Dani, JA Dani, JA Hill Jr, JA Wilking, JE Lisman, JJ Couey, JM Miwa, JM Miwa, JM Miwa, JM Williams, JP Changeux, JR Turner, JR Turner, JR Turner, JS Fowler, JS Fowler, JW Kenney, JZ Liu, KA Garrison, KJ Clemens, KJ Jackson, KJ Jackson, KJ Jackson, KJ Jackson, KP Cosgrove, KS Kendler, KS Okuyemi, L Lagostena, L Zhou, LJ Bierut, LM Tuesta, LP Dwoskin, LP Dwoskin, M Alkondon, M Alkondon, M Arvaniti, M De Biasi, M Foddai, M Kallupi, M Kassiou, M Yuan, M Zhang, MD Li, MI Damaj, MJ Marks, MJ Orejarena, ML Fisher, ML Goniewicz, MP Demars, MR Picciotto, MS Thomsen, MT Bardo, N Champtiaux, N Omelchenko, NI Nissen, NL Benowitz, NL Saccone, O Salminen, P Fagan, P Li, P Truman, PF Sullivan, PJ Welsby, R Girod, R Klink, R Miech, R Salas, R Srinivasan, RL Ashare, RS Caraballo, S Dodd, S Jones, S Kuhn, S Nakauchi, S Pons, S Tonstad, SD Alsharari, SD Alsharari, SS Sanjakdar, TT Smith, U Broms, U Maskos, V Gerzanich, W Berrettini, WA Corrigall, WD Myers, X Pang, Y Li, YY Huang, Z Jin   +146 more
core   +1 more source

HETEROCYCLIC SYNTHESIS USING NITRILIMINES: PART 18. SYNTHESIS OF NEW FUSED HETEROCYCLES CONTAINING TRIAZINONE MOIETY

Makara Seri Sains, 2011
A series of new 4,5-dihydro-6-oxo-1,2,4-triazino[4,5-b]1,2,3,4-tetrahydro-β-carbolines were synthesized by the reactionof methyl 1,2,3,4-tetrahydro-β-carboline-3-carboxylate and the appropriate hydrazonoyl halide in presence oftriethylamine.
Hany Mahmod Dalloul
doaj  

The Therapeutic Potentials of Ayahuasca: Possible Effects against Various Diseases of Civilization [PDF]

, 2016
Ayahuasca is an Amazonian psychoactive brew of two main components. Its active agents are β-carboline and tryptamine derivatives. As a sacrament, ayahuasca is still a central element of many healing ceremonies in the Amazon Basin and its ritual ...
Bokor, Petra, Frecska, Ede, Winkelman, Michael   +2 more
core   +2 more sources

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

Beilstein Journal of Organic Chemistry, 2011
The carboline ring system is an important pharmacophore found in a number of biologically important targets. Development of synthetic routes for the preparation of these compounds is important in order to prepare a range of analogues containing the ...
Jessica Baiget, Sabin Llona-Minguez, Stuart Lang, Simon P. MacKay, Colin J. Suckling, Oliver B. Sutcliffe   +5 more
doaj   +1 more source

Formation of Tetrahydro-β-Carbolines in Thermally Processed Foods and Their Detection Methods [PDF]

Shipin Kexue
Tetrahydro-β-carbolines (THβCs) are a class of alkaloids widely existing in foods, and the formation pathways of THβCs in the human body include endogenous and exogenous ones. The endogenous pathway is related to the metabolism of tryptophan in the human
CAO Jiamin, LI Xuechen, XU Jiahao, YANG Yong, HUI Teng
doaj   +1 more source

Norharmane matrix enhances detection of endotoxin by MALDI-MS for simultaneous profiling of pathogen, host, and vector systems [PDF]

, 2016
The discovery of novel pathogenic mechanisms engaged during bacterial infections requires the evolution of advanced techniques. Here, we evaluate the dual polarity matrix norharmane (NRM) to improve detection of bacterial lipid A (endotoxin), from host ...
Bligh, Brown, Caprioli, Cerruti, Chaurand, Conlan, Cornett, d'Hauteville, Elkins, Folch, Fuchs, Fuchs, Fuchs, Gunn, Gunn, Gusev, Hagar, Hajjar, Hamidi, Heeren, Kanistanon, Kwon, Li, Li, Luxembourg, Murphy, Nano, Nchoutmboube, Needham, Nicola, O'Hara, Ojeda, Pelletier, Quehenberger, Rasmussen, Ratledge, Schmeltz, Schmiemann, Schwamborn, Scott, Shaffer, Shirey, Soltwisch, Stoeckli, van Hove, Watson, White, Wojtowicz, Woolard, Yamagaki, Zemiski Berry, Zhang   +51 more
core   +1 more source