Results 61 to 70 of about 4,070 (167)

The cyanobacterial alkaloid nostocarboline: an inhibitor of acetylcholinesterase and trypsin [PDF]

, 2018
Preselected cyanobacterial strains (available from culture collections and our own isolates), belonging primarily to the heterocystous cluster, were screened for inhibitors against butyrylcholinesterase.
Baumann, Heike, Becher, Paul, Gademann, Karl, Jüttner, Friedrich   +3 more
core  

Harmaline Tremor: Underlying Mechanisms in a Potential Animal Model of Essential Tremor [PDF]

, 2012
Background: Harmaline and harmine are tremorigenic β-carbolines that, on administration to experimental animals, induce an acute postural and kinetic tremor of axial and truncal musculature. This drug-induced action tremor has been proposed as a model of
Handforth, Adrian
core   +4 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Frontiers in Behavioral Neuroscience, 2018
Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits.
Bruno Lobao-Soares, Paulianny Eduardo-da-Silva, Hugo Amarilha, Jaquelinne Pinheiro-da-Silva, Priscila F. Silva, Ana Carolina Luchiari   +5 more
doaj   +1 more source

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, EarlyView.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Foodborne Carcinogens: Formation Pathways, Health Risks, and Cutting‐Edge Physical and Chemical Prevention Strategies

eFood, Volume 7, Issue 3, June 2026.
This review highlights the formation of foodborne carcinogens during processing and evaluates different mitigation strategies, including natural antioxidants and modern cooking techniques, to reduce associated cancer risks and enhance food safety. ABSTRACT Food processing methods, though vital for improving food safety, taste, and shelf life, can ...
Naglaa S. Ashmawy, Ahmed A. Zaky, Noha H. Badr, Ali Korin, Mohamed A. Farag   +4 more
wiley   +1 more source

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

Therapeutic Potential of GABAergic Signaling in Myelin Plasticity and Repair

Frontiers in Cell and Developmental Biology, 2021
Oligodendrocytes (OLs) produce myelin to insulate axons. This accelerates action potential propagation, allowing nerve impulse information to synchronize within complex neuronal ensembles and promoting brain connectivity.
Daniel Reyes-Haro, Abraham Cisneros-Mejorado, Rogelio O. Arellano   +2 more
doaj   +1 more source

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae‐Chul Pyun, Min‐Jung Kang   +5 more
wiley   +1 more source