Results 61 to 70 of about 865,390 (142)

A Unified Strategy for the Synthesis of β‑Carbolines, γ‑Carbolines, and Other Fused Azaheteroaromatics under Mild, Metal-Free Conditions

, 2018
An efficient, unified approach for the synthesis of β-carbolines, γ-carbolines, and other fused azaheteroaromatics has been realized under metal-free conditions, from propargylic amines and (hetero)­aromatic aldehydes.
Dilipkumar Uredi (5807741), Dilipkumar Uredi, Damoder Reddy Motati, E. Blake Watkins (1478842), Damoder Reddy Motati (5367206), E. Blake Watkins   +5 more
core   +1 more source

Oxidation of Tetrahydro-β-carbolines by Persulfate

, 2019
The development of persulfate-mediated oxidation of tetrahydro-β-carbolines is reported. This mild reaction facilitates the formation of a variety of 2-formyl N-substituted tryptamines and the related derivatives as key intermediates in moderate to ...
Haijun Chen (580445), Jing Luo (146659), Yu Gao (69071), Fu Ye (7036157), Jing Luo, Fu Ye, Haijun Chen, Yu Gao   +7 more
core   +1 more source

β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications

, 1982
The inhibitory action of a range of β-carbolines on human and rat monoamine oxidase (MAO) A and B has been studied. Concentrations of 5-hydroxytryptamine and phenylethylamine, approximately at their Km values, were used as substrates for MAO A and B ...
Sandler, M., Liebowitz, J., Armando, Ines, Glover, Vivette   +3 more
core   +1 more source

Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids

Nature Communications
Tetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic approaches for stereoselective synthesis of tetrahydro-β-carboline skeletons have
Xiaochen Tian, Tengfei Xuan, Jingkun Gao, Xinyu Zhang, Tao Liu, Fengbiao Luo, Ruochen Pang, Pengcheng Shao, Yun-Fang Yang, Yang Wang   +9 more
doaj   +1 more source

Calorimetric, Thermogravimetric, and Theoretical Study of Norharmane, Harmane, and Harmine: Insights into the Energetics of β-Carbolines

Thermo
The thermochemical properties of Norharmane, Harmane, and Harmine were investigated using DSC, combustion calorimetry, thermogravimetry, and G3B3 computational methods.
Ana Ivette Delgado-Moreno, Raúl Ricardo Quiñonez-López, María de Jesús Palacios-Sánchez, Oscar Guillermo Zúñiga-González, Francisco Javier Moscoso-Sánchez, Eulogio Orozco-Guareño, Jesús Baudelio Campos-García   +6 more
doaj   +1 more source

Sc(OTf)₃‑Catalyzed C2-Selective Cyanation/Defluorination Cascade of Perfluoroalkylated 3‑Indolylmethanols and Application to the Synthesis of 3‑Fluoro(perfluoroalkyl)-β-carbolines

An unprecedented Sc­(OTf)3-catalyzed C2-selective cyanation/defluorination cascade of perfluoroalkylated 3-indolylmethanols with TMSCN is described, which provides a novel and practical strategy for the synthesis of structurally diverse 3-(2-cyano ...
Weidong Rao (1598017), Dandan Shang (11458496), Jichao Chen (108786), Qing Bao (1852243), Li Feng (77923), Jingjing Sang (11458493), Rui Hu (505795)   +6 more
core   +1 more source

β-Carbolines that accumulate in human tissues may serve a protective role against oxidative stress

, 2000
β-Carbolines are tricyclic nitrogen heterocycles formed in plants and animals as Maillard reaction products between amino acids and reducing sugars or aldehydes. They are being detected increasingly in human tissues, and their physiological roles need to
Pari, Koteppa, Balasubramanian, Dorairajan, Sivakama Sundari, C., Chandani, Sushil   +3 more
core   +1 more source

Enantioconvergent iso-Pictet-Spengler Reactions: Organocatalytic Synthesis of Chiral Tetrahydro-γ-carbolines

, 2023
Enantioconvergent iso-Pictet-Spengler reactions of chiral racemic ß-formyl esters and a ß-keto ester are reported, providing complex tetrahydro-γ-carbolines containing two contiguous stereocenters.
Jeffrey S. Johnson (1312380), Jeffrey S. Johnson, William R. Cassels (15369074), Jennifer L. Fulton, Jennifer L. Fulton (4025363), William R. Cassels   +5 more
core   +1 more source

Manganese dioxide mediated one-pot synthesis of methyl 9H-pyrido[3,4-b]indole-1-carboxylate: Concise synthesis of alangiobussinine

Beilstein Journal of Organic Chemistry, 2011
The carboline ring system is an important pharmacophore found in a number of biologically important targets. Development of synthetic routes for the preparation of these compounds is important in order to prepare a range of analogues containing the ...
Jessica Baiget, Sabin Llona-Minguez, Stuart Lang, Simon P. MacKay, Colin J. Suckling, Oliver B. Sutcliffe   +5 more
doaj   +1 more source

Formation of Tetrahydro-β-Carbolines in Thermally Processed Foods and Their Detection Methods [PDF]

Shipin Kexue
Tetrahydro-β-carbolines (THβCs) are a class of alkaloids widely existing in foods, and the formation pathways of THβCs in the human body include endogenous and exogenous ones. The endogenous pathway is related to the metabolism of tryptophan in the human
CAO Jiamin, LI Xuechen, XU Jiahao, YANG Yong, HUI Teng
doaj   +1 more source