Results 51 to 60 of about 865,390 (142)

Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs

European Journal of Medicinal Chemistry Reports
Carboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui, Wanru Gao, Ziwei Liu, Shuang Cao, Sihui Long   +4 more
doaj   +1 more source

β-Carbolines as specific inhibitors of cyclin-Dependent kinases

, 2002
Harmine (3), 7-fluoro-1-methyl β-carboline (35) and 1-(5-methyl-imidazol-4-yl) β-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases.
Wang, Jian, Wang, Jerry H., Yongcheng Song, Qi, Robert Zhong, Teng, Su Fern, Sim, Mui Mui, Yu Deng, Robert Zhong Qi, Su Fern Teng, Jerry H. Wang, Kesuma, Djohan, Deng, Yu, Song, Yongcheng, Jinao Duan, Mui Mui Sim, Jian Wang, Djohan Kesuma, Duan, Jinao   +17 more
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Synthesis of 1,4‐Disubstituted and 1‐Substituted β‐Carbolines via 3‐Substituted 2‐Acylindoles [PDF]

β-Carbolines represent a large class of bioactive natural products, whereby most of these alkaloids bear residues at C1, and occasionally at C3, and only limited examples of 1,4-disubstituted β-carbolines are known.
Untergehrer, Martin, Jourjine, Ilya A. P., Bracher, Franz, Thees, Katharina   +3 more
core   +1 more source

New reactions of 2-methyleneaziridines [PDF]

Chapter One reviews the synthesis, properties and reactions of 2-methyleneaziridines, the subject of this thesis. Chapter Two describes the use of these heterocycles in the development of a new four-component synthesis of biologically important α ...
Mumford, Peter Marten
core  

Inhibition of Monoamine Oxidase from Bovine Retina by β-Carbolines

, 1994
The behaviour of some β-carboline derivatives as inhibitors of monoamine oxidase has been studied in bovine retina. Inhibition was found not to show any significant time dependence.
M Unzeta, M D Balsa, J M Lizcano, A. Fernández De Arribam   +3 more
core   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source

Synthesis of 1,2,3,4-Tetrahydro-β-carbolines

, 1983
1,1-Disubstituted 1,2,3,4-tetrahydro-β-carbolines are formed by the action of trifluoroacetic acid on enamines derived from tryptamine or tryptophan. With methanolic hydrogen chloride, either cyclization to the corresponding β-carboline derivative, or ...
A Kirkpatrick, JA Maclaren
core   +1 more source

Mechanisms of DNA damage by photoexcited 9-methyl-β-carbolines [PDF]

, 2013
It has been well documented that β-carboline alkaloids, particularly the 9-methyl derivatives, are efficient photosensitizers. However, structure–activity relationships are missing and the photochemical mechanisms involved in the DNA photodamage still ...
Cabrerizo, Franco Martín, Rasse Suriani, Federico Ariel Osvaldo, Butzbach, Kathrin, Epe, Bernd, Erra Balsells, Rosa, Vignoni, Mariana   +5 more
core   +1 more source

Metal free one pot synthesis of β-carbolines via a domino Pictet-Spengler reaction and aromatization

, 2019
A convenient and efficient metal free, atom economical flexible synthesis of β-carbolines involving a domino Pictet-Spengler reaction and aromatization in oxygen atmosphere in N-methyl-2-pyrollidone (NMP) is described.
Balasubramanian, K.K., Ramu, S., Baskar, B., Srinath, S., Ilango, K., kumar, A. Aswin   +5 more
core   +1 more source

HETEROCYCLIC SYNTHESIS USING NITRILIMINES: PART 18. SYNTHESIS OF NEW FUSED HETEROCYCLES CONTAINING TRIAZINONE MOIETY

Makara Seri Sains, 2011
A series of new 4,5-dihydro-6-oxo-1,2,4-triazino[4,5-b]1,2,3,4-tetrahydro-β-carbolines were synthesized by the reactionof methyl 1,2,3,4-tetrahydro-β-carboline-3-carboxylate and the appropriate hydrazonoyl halide in presence oftriethylamine.
Hany Mahmod Dalloul
doaj