Results 51 to 60 of about 936,414 (160)
Журнал органічної та фармацевтичної хімії, 2020 Aim. To synthesize 4-cyanoindolo[2,3-c]pyrilium salts and examine their reactivity towards N-nucleophiles. Results and discussion. The acylation reaction of 2-(indolyl-3)-2-aroylacetonitriles under acid catalysis conditions was studied. 4-Cyanoindolo[2,3-
N. M. Bogdan +2 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 6, November 2026.ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan +3 more
wiley +1 more source
It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish
Frontiers in Behavioral Neuroscience, 2018 Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits.
Bruno Lobao-Soares +5 more
doaj +1 more source
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.Cyclopropylamines have emerged as powerful photocatalytic building blocks. Upon light‐induced single‐electron oxidation, they undergo strain‐release ring opening to generate distonic iminium radicals that enable diverse transformations, including ring‐opening functionalization, formal [3 + 2] cycloadditions, radical cascades, and asymmetric bond ...
Maria Chiara Cabua +3 more
wiley +1 more source
β-Carbolines as specific inhibitors of cyclin-Dependent kinases
, 2002 Harmine (3), 7-fluoro-1-methyl β-carboline (35) and 1-(5-methyl-imidazol-4-yl) β-carboline (41) were potent and specific inhibitors of cyclin-dependent kinases.
Wang, Jian +17 more
core +1 more source
European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados +1 more
wiley +1 more source
Anticancer α-, γ-, and δ-carboline derivatives: structures, mechanisms of action, and SARs
European Journal of Medicinal Chemistry ReportsCarboline consists of a pyridine ring fused with an indole skeleton, and it serves as a potential drug scaffold. Depending on the relative position of the pyridine N to the indole N, carbolines can be categorized into α-, β-, γ-, and δ-subfamilies.
Jingliang Cui +4 more
doaj +1 more source
β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)
Molecules, 2023 Monoamine oxidase (MAO) oxidizes neurotransmitters and xenobiotic amines, including vasopressor and neurotoxic amines such as the MPTP neurotoxin. Its inhibitors are useful as antidepressants and neuroprotectants.
Tomás Herraiz
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.Three new alkaloids, colombiains A–C (1–3), together with eight known ones (4–11) were isolated from the soft coral‐derived fungus Cladosporium colombiae CSGL 10M10. Compounds 6 and 11 exhibited significant cardioprotective activity against OGD/R‐induced injury in H9c2 cardiomyocytes at 10 µM.
Jing Xie +8 more
wiley +1 more source
A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and β-Carbolines
, 2016 Various tryptamines are captured by a vinylsulfonylmethyl polystyrene resin, generating a safety-catch linkage. β-Carbolines can be formed from 4 by a Pictet−Spengler reaction with the introduction of R1. Tryptamine 4 can also be derivatized by acylation
Peter G. Schultz (183240) +1 more
core +1 more source