Results 71 to 80 of about 936,414 (160)

β-Carbolines as selective monoamine oxidase inhibitors:In vivo implications

, 1982
The inhibitory action of a range of β-carbolines on human and rat monoamine oxidase (MAO) A and B has been studied. Concentrations of 5-hydroxytryptamine and phenylethylamine, approximately at their Km values, were used as substrates for MAO A and B ...
Sandler, M., Liebowitz, J., Armando, Ines, Glover, Vivette   +3 more
core   +1 more source

Facile synthesis of indolizino[8,7-b]indole and pyrido[1,2-a:3,4-b’]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro-β-carbolines

, 2022
A convenient approach to the synthesis of 1-aroyl-3,4-dihydro-β-carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse ...
Victor B. Rybakov (1490095), Alexey V. Varlamov (2433964), Leonid G. Voskressensky (2270389), Tatiana N. Borisova (14140730), Anna D. Zinoveva (14140727), Alexander A. Titov (14140733), Valentina V. Ilyushenkova (13216080), Elena A. Sorokina (14140736)   +7 more
core   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

Clinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 673-683, September 2026.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba, Titia Q. Ruijs, Annika A. de Goede, Robert J. Doll, Maria Juachon, Michel J. A. M. van Putten, Geert Jan Groeneveld, Jules A. A. C. Heuberger   +7 more
wiley   +1 more source

Synthesis of 1,2,3,4-Tetrahydro-β-carbolines

, 1983
1,1-Disubstituted 1,2,3,4-tetrahydro-β-carbolines are formed by the action of trifluoroacetic acid on enamines derived from tryptamine or tryptophan. With methanolic hydrogen chloride, either cyclization to the corresponding β-carboline derivative, or ...
A Kirkpatrick, JA Maclaren
core   +1 more source

Alcoholic extracts of Russian sage (Salvia yangii) contain bioactive terpenoids with inhibitory activity against grapevine downy mildew (Plasmopara viticola)

Pest Management Science, Volume 82, Issue 9, Page 8159-8170, September 2026.
Alcoholic extracts from flowers, leaves, and shoots of Russian sage decreased downy mildew severity on grapevine leaf disks. Fractionation followed by metabolomic analysis revealed putative terpenoids as the main components of the active fractions. Specifically, 7‐methylrosmanol, 12‐O‐methylcarnosic acid, carnosic acid, and carnosol were identified as ...
Anna Smaldone, Oscar Giovannini, Martina Magni, Michael Oberhuber, Peter Robatscher, Michele Perazzolli   +5 more
wiley   +1 more source

Modulation of GABA-stimulated chloride influx by beta-carbolines in rat brain membrane vesicles

, 1988
We have shown that GABA-stimulated chloride influx into membrane vesicles from the rat cerebral cortex can be enhanced or inhibited by β-carbolines.
SERRA, MARIANGELA, Ikeda M, Yamamura H.I., Malatynska E, Biggio G   +4 more
core   +1 more source

HETEROCYCLIC SYNTHESIS USING NITRILIMINES: PART 18. SYNTHESIS OF NEW FUSED HETEROCYCLES CONTAINING TRIAZINONE MOIETY

Makara Seri Sains, 2011
A series of new 4,5-dihydro-6-oxo-1,2,4-triazino[4,5-b]1,2,3,4-tetrahydro-β-carbolines were synthesized by the reactionof methyl 1,2,3,4-tetrahydro-β-carboline-3-carboxylate and the appropriate hydrazonoyl halide in presence oftriethylamine.
Hany Mahmod Dalloul
doaj  

Syntheses of Tetrahydro-β-Carbolines via Tandem Hydformylation / Pictet-Spengler Reaction, Scope and limitations

, 2008
A novel one-pot synthesis of tetrahydro-β-carboline systems via tandem hydroformylation–Pictet–Spengler reaction starting from olefins and aryl ethylamines is described.
Bondžić, Bojan, Eilbracht, Peter
core   +1 more source

1-Substituted β-Carbolines by a Pictet−Spengler Cyclization with Thioortho Esters and Carbon−Carbon Bond Formation via N-Sulfonyl Iminium Ions Generated from N,S-Sulfonyl Acetals

, 2016
The reaction of N-tosyltryptamines with thioortho esters, leading to 1-thiosubstituted tetrahydro-β-carbolines under modified Pictet−Spengler conditions, is described.
Luciana A. Felix (2335600), Teodoro S. Kaufman (2673634), Claudio C. Silveira (1814443), Antonio L. Braga (621954)   +3 more
core   +1 more source