Results 71 to 80 of about 4,070 (167)

From Heteroaromatic acids and Imines to Azaspirocycles : Stereoselective Synthesis and 3D Shape Analysis [PDF]

, 2016
Heteroaromatic carboxylic acids have been directly coupled with imines using T3P and NEt(i-Pr)2 to form azaspirocycles via intermediate N-acyliminium ions.
Bailey, Blicke, Bonjoch, Böhme, Carreira, Chen, Coulthard, Dhankher, Firth, Gao, Heffernan, Hung, Jackson, Jackson, James, James, James, Jensen, Khorana, Kitsiou, Klein, Li, Liedtke, Lovering, Lüthy, Marti, Maryanoff, Menciu, Meyer, Morley, Mérour, Okano, Overman, Peshkov, Piazzi, Roche, Sauer, Shabalina, Shanker, Shao, Shi, Siau, Sippy, Stöckigt, Taylor, Trzupek, Unsworth, Unsworth, Unsworth, Unsworth, Vitaku, Wagnières, Walton, Wang, Woodward, Wu, Wu, Wu, Zheng, Zheng, Zhou, Zhu, Zhuo, Zhuo, Zhuo, Zhuo   +65 more
core   +2 more sources

Synthesis of 2‐Aryl(alkyl)benzimidazole Hydroxamic Acids as HDAC Inhibitors with Anti‐Angiogenesis Properties

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
2‐Aryl(alkyl)benzimidazole hydroxamic acids (11‐16) are potent and selective HDAC6 inhibitors, with minimal activity against HDAC1/2, and also display anti‐angiogenic and anticancer activities. Compound 13 exhibited a GI50 of 3.9 μM against EPCs and inhibited the growth of HCT‐116, SK‐Hep‐1, and PC‐3 cells with GI50 values of 1.3, 4.2, and 7.5 μM ...
Yi‐Ting Liu, Cheng‐Ta Lai, Shih‐Wei Wang, Shan‐Chi Liu, Yi‐Lin Hwang, Yi‐Chen Tsai, Chi‐Yeh Lee, Yu‐Wei Lai, Juei‐Yu Yen, Po‐Chuan Wang, Hsueh‐Yun Lee   +10 more
wiley   +1 more source

Evaluation of mutagenicity and antimutagenicity of different fractions of Pterogyne nitens (Leguminosae), using Tradescantia pallida micronuclei assay [PDF]

, 2009
Pterogyne nitens (Fabaceae-Caesalpinioideae) é uma árvore nativa da América do Sul, onde é empregada na medicina popular para o tratamento da ascaridíase. Recentemente, descrevemos o efeito mutagênico do extrato etanólico das folhas de P. nitens.
BASSI, Carmen L., BOLZANI, Vanderlan da S., CAMPOS, Juliana A. D. B., CAVALHEIRO, Alberto J., FERREIRA, Fernanda G., OLIVEIRA, Aline M. de, REGASINI, Luis O., SANTOS, Raquel A. dos, SILVA, Dulce H. S., SOARES, Christiane P.   +9 more
core   +2 more sources

A Novel Approach to Highly Substituted β‐Carbolines via Reductive Ring Transformation of 2‐Acyl‐3‐isoxazolylindoles [PDF]

, 2020
We have worked out a new approach to 1,3,4‐trisubstituted β‐carbolines of pharmaceutical interest. As central building blocks we used 2‐acylindoles, which are readily available from indole‐2‐Weinreb amides.
Day R. A., Lefoix M., Whaley W. M., Zhang H., Zhao Y.   +4 more
core   +1 more source

Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice [PDF]

, 2014
Introduction: Passiflora incarnata (PI) is one of the commonest herbal anti-anxiety and sedative agents. The aim of the present study was to investigate the antidepressant effect of hydroalcoholic extract of PI in forced swim test (FST) and tail ...
Abbasi-Maleki, Saeid., Asadi-Samani, Majid., Jafarpoor, Nima., Khayatnouri, Mir Hadi.   +3 more
core  

Wherefore the Magic? The Evolutionary Role of Psilocybin in Nature

Ecology and Evolution, Volume 16, Issue 4, April 2026.
This study explores the evolutionary role of psilocybin, the psychedelic compound found in Psilocybe mushrooms. We provide the first experimental tests of defence and community‐level evidence for invertebrate responses to psilocybin‐producing fungi, revealing significant negative effects on invertebrate locomotion, development, and survival.
K. J. Matthews Nicholass, I. Flis, M. E. Hanley, M. E. Knight, S. M. Lane, G. Littlejohn, M. D. F. Thom, R. A. Billington, R. Boden, R. Cummins, B. J. Green, C. Griffin, S. Jones, D. Salmon, I. Sleep, N. Smirnoff, J. S. Ellis   +16 more
wiley   +1 more source

Da Yuan Yin Regulates Gut Microbiota and Improves Intestinal Injury in Sepsis

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Sepsis mouse model was induced by LPS to investigate the effect of Da Yuan Yin (DYY) in vivo. Hematoxylin–eosin staining showed that DYY could reduce intestinal injury caused by sepsis. In addition, DYY can also inhibit inflammation, apoptosis, and promote cell proliferation in sepsis, and promote the expression of tight junction proteins.
Li Wang, Yuan‐Yuan Sha, Guan‐Yu Hu, Yi‐Ming Qian, Jian Guo   +4 more
wiley   +1 more source

Development of a Novel, Simultaneous Determination Method for Heterocyclic Amines and Mycotoxins in Fried Food by UPLC–MS/MS Combined With QuEChERS

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
• A novel QuEChERS‐UPLC‐MS/MS method was successfully developed for the simultaneous determination of two β‐carboline heterocyclic amines and seven mycotoxins in fried foods. ABSTRACT Dietary exposure to both processing contaminants and natural toxins in fried foods poses a potential health risk, but analytical methods for their simultaneous monitoring
Diaodiao Yang, Jianwen Liu, Yang Song, Yajing Ma, Hongkang Zhu, Qingfeng Zhou, Maomao Zeng   +6 more
wiley   +1 more source

Development of a Bioactive Food Additive for Controlling of Fungal Growth [PDF]

, 2017
Fresh foods have a great importance in human nutrition. However, they are marketed with greatly reduced shelf life mainly due to fungal spoilage. In this work, cell wall degrading enzymes produced by Trichoderma asperellum T00 (TCWDE) were immobilized ...
Batista, K. A. (Karla), Cruz, M. V. (Mauricio), Fernandes, K. F. (Katia), Pereira-Junior, M. A. (Marcos)   +3 more
core   +1 more source

Pd(II)-catalyzed C–H annulation and lactonization of indole-2-carboxamides with hydroxyalkynoates using air as an oxidant

Tetrahedron Chem
A novel palladium(II) catalyzed C–H annulation strategy has been developed for the synthesis of a diverse range of furo[3′,4':5,6]pyrido[3,4-b]indole-1,5(3H)-dione scaffolds. This is the first report on the construction of polycyclic carboline frameworks
Kiran Aswale, Rajashaker Bantu, B. Sridhar, B.V. Subba Reddy   +3 more
doaj   +1 more source