Results 71 to 80 of about 4,115 (172)

Total Synthesis of rac‐Keramamine C Enabled by Intrinsic H‐Bond‐Induced Conformational Fixation of Amides

European Journal of Organic Chemistry, Volume 29, Issue 18, 14 May 2026.
The total synthesis of the manzamine alkaloid keramamine C (2) in its racemic form was achieved in 5 steps, with ring‐closing metathesis as the key step. The metathesis is strongly improved by an intramolecular H‐bond‐induced conformational fixation of the amide bond, inducing close proximity of the terminal double bonds in the precursor molecule.
Jana Ganzmann, Ryan Thurston, Pascal Riester, Nina Hegmann, Markus R. Heinrich   +4 more
wiley   +1 more source

From Heteroaromatic acids and Imines to Azaspirocycles : Stereoselective Synthesis and 3D Shape Analysis [PDF]

, 2016
Heteroaromatic carboxylic acids have been directly coupled with imines using T3P and NEt(i-Pr)2 to form azaspirocycles via intermediate N-acyliminium ions.
Bailey, Blicke, Bonjoch, Böhme, Carreira, Chen, Coulthard, Dhankher, Firth, Gao, Heffernan, Hung, Jackson, Jackson, James, James, James, Jensen, Khorana, Kitsiou, Klein, Li, Liedtke, Lovering, Lüthy, Marti, Maryanoff, Menciu, Meyer, Morley, Mérour, Okano, Overman, Peshkov, Piazzi, Roche, Sauer, Shabalina, Shanker, Shao, Shi, Siau, Sippy, Stöckigt, Taylor, Trzupek, Unsworth, Unsworth, Unsworth, Unsworth, Vitaku, Wagnières, Walton, Wang, Woodward, Wu, Wu, Wu, Zheng, Zheng, Zhou, Zhu, Zhuo, Zhuo, Zhuo, Zhuo   +65 more
core   +2 more sources

Evaluation of antidepressant-like effect of hydroalcoholic extract of Passiflora incarnata in animal models of depression in male mice [PDF]

, 2014
Introduction: Passiflora incarnata (PI) is one of the commonest herbal anti-anxiety and sedative agents. The aim of the present study was to investigate the antidepressant effect of hydroalcoholic extract of PI in forced swim test (FST) and tail ...
Abbasi-Maleki, Saeid., Asadi-Samani, Majid., Jafarpoor, Nima., Khayatnouri, Mir Hadi.   +3 more
core  

Evaluation of mutagenicity and antimutagenicity of different fractions of Pterogyne nitens (Leguminosae), using Tradescantia pallida micronuclei assay [PDF]

, 2009
Pterogyne nitens (Fabaceae-Caesalpinioideae) é uma árvore nativa da América do Sul, onde é empregada na medicina popular para o tratamento da ascaridíase. Recentemente, descrevemos o efeito mutagênico do extrato etanólico das folhas de P. nitens.
BASSI, Carmen L., BOLZANI, Vanderlan da S., CAMPOS, Juliana A. D. B., CAVALHEIRO, Alberto J., FERREIRA, Fernanda G., OLIVEIRA, Aline M. de, REGASINI, Luis O., SANTOS, Raquel A. dos, SILVA, Dulce H. S., SOARES, Christiane P.   +9 more
core   +2 more sources

Mo‐Catalyzed Synthesis of N‐Polyheterocycles From Functionalized Nitroarenes and Aldehydes

Asian Journal of Organic Chemistry, Volume 15, Issue 5, May 2026.
Mo(VI)‐catalyzed one‐pot conversion of readily available functionalized nitroarenes and aldehydes yielded fused N‐polyheterocycles by sequential nitro reduction, imine formation, and cyclization. Using pinacol as a benign reductant, this sustainable tandem strategy suppresses side reactions and grants rapid access to diverse pharmacologically relevant ...
Raúl Martínez‐González, Rubén Rubio‐Presa, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +4 more
wiley   +1 more source

A Novel Approach to Highly Substituted β‐Carbolines via Reductive Ring Transformation of 2‐Acyl‐3‐isoxazolylindoles [PDF]

, 2020
We have worked out a new approach to 1,3,4‐trisubstituted β‐carbolines of pharmaceutical interest. As central building blocks we used 2‐acylindoles, which are readily available from indole‐2‐Weinreb amides.
Day R. A., Lefoix M., Whaley W. M., Zhang H., Zhao Y.   +4 more
core   +1 more source

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

Tenofovir, Interferon Pathways, and Mucosal Immunity: Implications for People Living With HIV

American Journal of Reproductive Immunology, Volume 95, Issue 5, May 2026.
ABSTRACT Background Antiretroviral therapy (ART) suppresses HIV replication and protects people living with HIV (PLWH) from progressing to AIDS. However, despite ART, many PLWH experience chronic immune activation, which contributes to premature aging and non‐AIDS‐related comorbidities. One reason for this chronic immune activation (CIA) is HIV and its
Florian Hladik, Sean M. Hughes, Claire N. Levy, Rachel L. Creighton, Romel Mackelprang, Germán G. Gornalusse   +5 more
wiley   +1 more source

Development of a Bioactive Food Additive for Controlling of Fungal Growth [PDF]

, 2017
Fresh foods have a great importance in human nutrition. However, they are marketed with greatly reduced shelf life mainly due to fungal spoilage. In this work, cell wall degrading enzymes produced by Trichoderma asperellum T00 (TCWDE) were immobilized ...
Batista, K. A. (Karla), Cruz, M. V. (Mauricio), Fernandes, K. F. (Katia), Pereira-Junior, M. A. (Marcos)   +3 more
core   +1 more source

Inhibitory Activity of Conferone on FAK Activity and Glutamine Metabolism in Human Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Colorectal cancer (CRC) is a major global cause of death, with metastases and chemotherapy resistance contributing to poor outcomes. To identify natural compounds with anticancer potential against CRC and elucidate their action mechanisms, the cytotoxicity of 37 natural compounds was evaluated against the HCT116, leading to the identification ...
Hien Thi My Ong, Eda Ates, Jaeyong Jung, Jeong Soo Sung, Jae‐Chul Pyun, Min‐Jung Kang   +5 more
wiley   +1 more source