Results 41 to 50 of about 865,390 (142)

Palladium(II)-Catalyzed Asymmetric Tandem Cyclization of 2‑Aminoaryl Alkynones: An Approach to Chiral 1,2,3,4-Tetrahydro-β-carbolines

, 2018
A Pd­(OAc)2-catalyzed asymmetric cyclization of 2-aminoaryl alkynones involving an intramolecular trans-aminopalladation of alkyne and 1,2-addition to the carbonyl group tandem processes was developed.
Junjie Chen, Junjie Chen (48472), Xiyan Lu (1470865), Xiuling Han (1555261), Xiyan Lu, Xiuling Han   +5 more
core   +1 more source

Indole Alkaloids from Psychoactive Mushrooms: Chemical and Pharmacological Potential as Psychotherapeutic Agents

Biomedicines, 2023
Neuropsychiatric diseases such as depression, anxiety, and post-traumatic stress represent a substantial long-term challenge for the global health systems because of their rising prevalence, uncertain neuropathology, and lack of effective pharmacological
Erika Plazas, Nicoletta Faraone
doaj   +1 more source

Cigarette Smoke Extract, but Not Electronic Cigarette Aerosol Extract, Inhibits Monoamine Oxidase in vitro and Produces Greater Acute Aversive/Anhedonic Effects Than Nicotine Alone on Intracranial Self-Stimulation in Rats

Frontiers in Neuroscience, 2022
Conventional tobacco cigarettes appear to have greater abuse liability than non-combusted products such as electronic cigarettes (ECs) and nicotine replacement therapy (NRT).
Andrew C. Harris, Andrew C. Harris, Andrew C. Harris, Peter Muelken, Aleksandra Alcheva, Irina Stepanov, Mark G. LeSage, Mark G. LeSage, Mark G. LeSage   +8 more
doaj   +1 more source

Facile synthesis of indolizino[8,7-b]indole and pyrido[1,2-a:3,4-b’]diindole derivatives based on domino reactions of 1-aroyl-3,4-dihydro-β-carbolines

, 2022
A convenient approach to the synthesis of 1-aroyl-3,4-dihydro-β-carbolines via Pictet–Spengler reaction has been developed. A variety of reagents, such as unsaturated aldehydes, ketones, maleic anhydride in the construction of functionally diverse ...
Victor B. Rybakov (1490095), Alexey V. Varlamov (2433964), Leonid G. Voskressensky (2270389), Tatiana N. Borisova (14140730), Anna D. Zinoveva (14140727), Alexander A. Titov (14140733), Valentina V. Ilyushenkova (13216080), Elena A. Sorokina (14140736)   +7 more
core   +1 more source

β-Carbolines Norharman and Harman change neurobehavior causing neurological damage in Caenorhabditis elegans

, 2023
β-Carbolines norharman and harman, belonging to the class of heterocyclic aromatic amines (HAAs), are typical hazardous substances produced during the thermal processing of food.
Bufan Xu, Liu, Jialu, Di Wu, Wu, Yongning, Jialu Liu, Yongning Wu, Wu, Di; id_orcid, Guoliang Li, Zhang, Luyao, Xu, Bufan, Li, Guoliang, Luyao Zhang   +11 more
core   +1 more source

Acylation of indolyl subsituted β-ketonitriles. The way to new indolo[2,3-c]pyrilium and β-carboline derivatives

Журнал органічної та фармацевтичної хімії, 2020
Aim. To synthesize 4-cyanoindolo[2,3-c]pyrilium salts and examine their reactivity towards N-nucleophiles. Results and discussion. The acylation reaction of 2-(indolyl-3)-2-aroylacetonitriles under acid catalysis conditions was studied. 4-Cyanoindolo[2,3-
N. M. Bogdan, S. L. Bogza, Yu. A. Nikolyukin   +2 more
doaj   +1 more source

It’s Tea Time: Interference of Ayahuasca Brew on Discriminative Learning in Zebrafish

Frontiers in Behavioral Neuroscience, 2018
Ayahuasca is a psychoactive brew traditionally used in shamanistic and vegetalistic rituals and has recently received lot of attention due to potential cognitive benefits.
Bruno Lobao-Soares, Paulianny Eduardo-da-Silva, Hugo Amarilha, Jaquelinne Pinheiro-da-Silva, Priscila F. Silva, Ana Carolina Luchiari   +5 more
doaj   +1 more source

A Versatile Linkage Strategy for Solid-Phase Synthesis of N,N-Dimethyltryptamines and β-Carbolines

, 2016
Various tryptamines are captured by a vinylsulfonylmethyl polystyrene resin, generating a safety-catch linkage. β-Carbolines can be formed from 4 by a Pictet−Spengler reaction with the introduction of R1. Tryptamine 4 can also be derivatized by acylation
Peter G. Schultz (183240), Tom Y. H. Wu (3064386)   +1 more
core   +1 more source

β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)

Molecules, 2023
Monoamine oxidase (MAO) oxidizes neurotransmitters and xenobiotic amines, including vasopressor and neurotoxic amines such as the MPTP neurotoxin. Its inhibitors are useful as antidepressants and neuroprotectants.
Tomás Herraiz
doaj   +1 more source

Expanding the scope of the Bohlmann-Rahtz reaction: new routes to 3-nitropyridines, ?-carbolines, and ß-carbolines

, 2022
Chapter One opens with an overview of the role of pyridines in the pharmaceutical industry. This is followed by an in-depth survey of literature methods that have been reported for pyridine synthesis, including the Bohlmann-Rahtz reaction.
Tyler Nichols (4466107)
core   +1 more source