Results 21 to 30 of about 1,867 (125)

Morita–Baylis–Hillman reaction of 3-formyl-9H-pyrido[3,4-b]indoles and fluorescence studies of the products

Beilstein Journal of Organic Chemistry, 2022
β-Carboline is a privileged class of the alkaloid family and is associated with a broad spectrum of biological properties. 3-Formyl-9H-pyrido[3,4-b]indole is a such potent precursor belonging to this family which can be tailored for installing diversity ...
Nisha Devi, Virender Singh
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Natural surfactants assisted an efficient synthesis of tetrahydro-β-carbolines

Results in Chemistry, 2021
An expeditious protocol for the synthesis of structurally diversified β-carboline derivatives has been reported using a readily available natural surfactant medium.
Somnath S. Gholap, Vinod R. Kadu
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Biodiversity of β-Carboline Profile of Banisteriopsis caapi and Ayahuasca, a Plant and a Brew with Neuropharmacological Potential

Plants, 2020
Ayahuasca is a psychoactive infusion with a large pharmacological application normally prepared with Banisteriopsis caapi, which contains the monoamine oxidase inhibitors β-carbolines, and Psichotria virids, which contains the serotonin receptor agonist ...
Beatriz Werneck Lopes Santos, Regina Célia de Oliveira, Julia Sonsin-Oliveira, Christopher William Fagg, José Beethoven Figueiredo Barbosa, Eloisa Dutra Caldas   +5 more
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Diversity-oriented synthesis derived indole based spiro and fused small molecules kills artemisinin-resistant Plasmodium falciparum

Malaria Journal, 2021
Background Despite numerous efforts to eradicate the disease, malaria continues to remain one of the most dangerous infectious diseases plaguing the world. In the absence of any effective vaccines and with emerging drug resistance in the parasite against
Akshaykumar Nayak, Himani Saxena, Chandramohan Bathula, Tarkeshwar Kumar, Souvik Bhattacharjee, Subhabrata Sen, Ashish Gupta   +6 more
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Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
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Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents

Results in Chemistry, 2022
β-Carbolines are of great interest due to their broad spectrum of biochemical effects and pharmaceutical functions, especially antitumor activity. The N9 position at β-carboline is a modification site for important antitumor activity. Several phenylfuran
Zhi Huang, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang   +9 more
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Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes

Journal of Toxicology, 2011
Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that some α-, β-, and γ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human ...
Hironori Tsuchiya
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Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Organics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries, Françoise A. Aouane, Thomas J. J. Müller   +2 more
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Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation

Frontiers in Pharmacology, 2021
The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese medicine, Kumu, which was effective for microbial infection, inflammation, fever, and dysentery, etc.
Haibo Hu, Haibo Hu, Changling Hu, Jinnian Peng, Alokesh Kumar Ghosh, Ajmal Khan, Dan Sun, Dan Sun, Walter Luyten   +8 more
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Comprehensive review of β-carbolines from microbes and their biosynthesis

European Journal of Medicinal Chemistry Reports
β-carbolines were historically known as plant-derived metabolites. They are known to exhibit a broad spectrum of biological activities with clinical and economic significance.
Mary Ayeko Twumasi, Matthew Peter Kusche, Amna Farzeen Baig, S. Eric Nybo, Madan Kumar Kharel   +4 more
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