Comprehensive review of β-carbolines from microbes and their biosynthesis
European Journal of Medicinal Chemistry Reportsβ-carbolines were historically known as plant-derived metabolites. They are known to exhibit a broad spectrum of biological activities with clinical and economic significance.
Mary Ayeko Twumasi +4 more
doaj +2 more sources
Anti-inflammatory effects of Banisteriopsis caapi and beta-carbolines in neuronal cells: potential implications for neuro-COVID [PDF]
Frontiers in PharmacologyBackgroundNeuroinflammation plays a central role in neurodegenerative diseases such as Alzheimer’s and Parkinson’s, along with depression, anxiety, and infectious diseases including COVID-19.
Laura Seixas Bianco +12 more
doaj +2 more sources
Tricyclic Imidazolidin-4-ones by Witkop Oxidation of Tetrahydro-β-carbolines. [PDF]
J Org Chem, 2020 1-Substituted and 1,1-disubstituted tetrahydro-β-carbolines undergo sodium periodate oxidative ring expansion in the presence of formaldehyde and other aldehydes to form 5,6-dihydro-7H-1,4-methanobenzo[e][1,4]diazonine-2,7(3H)-diones in 30–81% yield.
Leas DA +6 more
europepmc +3 more sources
Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N‑(3-Hydroxyindole)-Appended β‑Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer [PDF]
ACS Omega, 2020 Bharvi Sharma +7 more
doaj +2 more sources
Bioactive β-Carbolines in Food: A Review [PDF]
Nutrients, 2019 Paulina Piechowska +2 more
exaly +2 more sources
Effect of Chemical Refining on the Reduction of β-Carboline Content in Sesame Seed Oil
Molecules, 2023 β-carbolines (harman and norharman) are potentially mutagenic and have been reported in some vegetable oils. Sesame seed oil is obtained from roasted sesame seeds. During sesame oil processing, roasting is the key procedure to aroma enhancement, in which
Lili Shi, Ziyu Cui, Wei Liu
doaj +1 more source
Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs: Review
Ethiopian Journal of Science and Sustainable Development, 2022 1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a large group of natural and synthetic indole alkaloids that possess a common tricyclic pyrido[3,4-b] indole scaffold that are widely distributed in nature.
Ayana Melaku Yadessa, Nigatu Bejigo
doaj +1 more source
Synthesis of α- and β-Carbolines by a Metalation/Negishi Cross-Coupling/SNAr Reaction Sequence [PDF]
, 2021 Carbolines are considered to be privileged scaffolds in medicinal chemistry. An efficient method for the synthesis of α- and β-carbolines from fluoropyridines and 2-haloanilines is reported.
Stefan, Roesner +1 more
core +2 more sources
Bioactivity of selected materials for coffee substitute. [PDF]
PLoS ONE, 2018 Epidemiological studies have suggested that coffee consumption is negatively correlated with the incidence of Parkinson's disease. Coffee contains relatively high levels of β-carbolines, which have been ascribed neuroactive effects in humans however the ...
Renata Zawirska-Wojtasiak +4 more
doaj +1 more source
Foods, 2022 Heat treatment of meat can lead to the formation of carcinogenic organic compounds. The influence of dried fruits on the formation of non-polar heterocyclic aromatic amines (carbolines) and nitrogen derivatives of polycyclic aromatic hydrocarbons ...
Ewa Śnieżek +4 more
doaj +1 more source