β-carbolines that enhance GABAA receptor response expressed in oligodendrocytes promote remyelination in an in vivo rat model of focal demyelination [PDF]
Frontiers in Cellular NeuroscienceDemyelination is typically followed by a remyelination process through mature oligodendrocytes (OLs) differentiated from precursor cells (OPCs) recruited into the lesioned areas, however, this event usually results in uncompleted myelination ...
Abraham Jotssel Cisneros-Mejorado +3 more
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The Chiral Pool in the Pictet–Spengler Reaction for the Synthesis of β-Carbolines [PDF]
Molecules, 2016 The Pictet–Spengler reaction (PSR) is the reaction of a β-arylethylamine with an aldehyde or ketone, followed by ring closure to give an aza-heterocycle.
Renato Dalpozzo
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Design, Synthesis, Antiproliferative Evaluation, and Molecular Docking Studies of N‑(3-Hydroxyindole)-Appended β‑Carbolines/Tetrahydro-β-Carbolines Targeting Triple-Negative and Non-Triple-Negative Breast Cancer [PDF]
ACS Omega, 2020 Bharvi Sharma +7 more
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Bioactive β-Carbolines in Food: A Review. [PDF]
Nutrients, 2019 Piechowska P +2 more
europepmc +2 more sources
Effect of Chemical Refining on the Reduction of β-Carboline Content in Sesame Seed Oil
Molecules, 2023 β-carbolines (harman and norharman) are potentially mutagenic and have been reported in some vegetable oils. Sesame seed oil is obtained from roasted sesame seeds. During sesame oil processing, roasting is the key procedure to aroma enhancement, in which
Lili Shi, Ziyu Cui, Wei Liu
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Development in the Synthesis and Biological Activities of THβ-carboline and Its Analogs: Review
Ethiopian Journal of Science and Sustainable Development, 2022 1,2,3,4-Tetrahydro-β-carbolines (THβCs) are a large group of natural and synthetic indole alkaloids that possess a common tricyclic pyrido[3,4-b] indole scaffold that are widely distributed in nature.
Ayana Melaku Yadessa, Nigatu Bejigo
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Foods, 2022 Heat treatment of meat can lead to the formation of carcinogenic organic compounds. The influence of dried fruits on the formation of non-polar heterocyclic aromatic amines (carbolines) and nitrogen derivatives of polycyclic aromatic hydrocarbons ...
Ewa Śnieżek +4 more
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Bioactivity of selected materials for coffee substitute. [PDF]
PLoS ONE, 2018 Epidemiological studies have suggested that coffee consumption is negatively correlated with the incidence of Parkinson's disease. Coffee contains relatively high levels of β-carbolines, which have been ascribed neuroactive effects in humans however the ...
Renata Zawirska-Wojtasiak +4 more
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Mild and efficient ammonium chloride catalyzed Greener synthesis of tetrahydro-β-carboline
Current Research in Green and Sustainable Chemistry, 2022 This protocol involves the NH4Cl catalyzed Pictet−Spengler reactions of tryptamine and arylaldehydes in anhydrous MeOH solvent to gives corresponding tetrahydro-β-carbolines (THβC) with 90% yield. This methodology offers mild, efficient and green reagent
Milind V. Gaikwad +2 more
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UVA photoactivation of harmol enhances its antifungal activity against the phytopathogens Penicillium digitatum and Botrytis cinerea [PDF]
, 2017 Phytopathogenic fungi responsible for post-harvest diseases on fruit and vegetables cause important economic losses. We have previously reported that harmol (1-methyl-9H-pyrido[3,4-b]indol-7-ol) is active against the causal agents of green and gray molds
Cabrerizo, Franco Martín +5 more
core +1 more source