Results 31 to 40 of about 936,414 (160)

β-Carbolines Norharman and Harman change neurobehavior causing neurological damage in Caenorhabditis elegans [PDF]

, 2023
β-Carbolines norharman and harman, belonging to the class of heterocyclic aromatic amines (HAAs), are typical hazardous substances produced during the thermal processing of food.
Bufan Xu, Liu, Jialu, Di Wu, Wu, Yongning, Jialu Liu, Yongning Wu, Wu, Di; id_orcid, Guoliang Li, Zhang, Luyao, Xu, Bufan, Li, Guoliang, Luyao Zhang   +11 more
core   +1 more source

Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes

Journal of Toxicology, 2011
Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that some α-, β-, and γ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human ...
Hironori Tsuchiya
doaj   +1 more source

Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
doaj   +1 more source

Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents

Results in Chemistry, 2022
β-Carbolines are of great interest due to their broad spectrum of biochemical effects and pharmaceutical functions, especially antitumor activity. The N9 position at β-carboline is a modification site for important antitumor activity. Several phenylfuran
Zhi Huang, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang   +9 more
doaj   +1 more source

Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation

Frontiers in Pharmacology, 2021
The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese medicine, Kumu, which was effective for microbial infection, inflammation, fever, and dysentery, etc.
Haibo Hu, Haibo Hu, Changling Hu, Jinnian Peng, Alokesh Kumar Ghosh, Ajmal Khan, Dan Sun, Dan Sun, Walter Luyten   +8 more
doaj   +1 more source

Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Organics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries, Françoise A. Aouane, Thomas J. J. Müller   +2 more
doaj   +1 more source

Computational Insights into β-Carboline Inhibition of Monoamine Oxidase A

Molecules, 2022
Monoamine oxidases (MAOs) are an important group of enzymes involved in the degradation of neurotransmitters and their imbalanced mode of action may lead to the development of various neuropsychiatric or neurodegenerative disorders.
Alja Prah, Tanja Gavranić, Andrej Perdih, Marija Sollner Dolenc, Janez Mavri   +4 more
doaj   +1 more source

An oxidative amidation and heterocyclization approach for the synthesis of β-carbolines and dihydroeudistomin Y

Beilstein Journal of Organic Chemistry, 2014
A novel synthetic methodology has been developed for the synthesis of dihydro-β-carboline derivatives employing oxidative amidation–Bischler–Napieralski reaction conditions using tryptamine and 2,2-dibromo-1-phenylethanone as key starting materials.
Suresh Babu Meruva, Akula Raghunadh, Raghavendra Rao Kamaraju, U. K. Syam Kumar, P. K. Dubey   +4 more
doaj   +1 more source

In vitro Effect of Harmine Alkaloid and Its N-Methyl Derivatives Against Toxoplasma gondii

Frontiers in Microbiology, 2021
Toxoplasmosis is one of the most prevalent and neglected zoonotic global diseases caused by Toxoplasma gondii. The current pharmacological treatments show clinical limitations, and therefore, the search for new drugs is an urgent need in order to ...
Maria L. Alomar, Juan G. Yañuk, Sergio O. Angel, M. Micaela Gonzalez, Franco M. Cabrerizo   +4 more
doaj   +1 more source

Mo‐Catalyzed Synthesis of 3‐Substituted Quinolines From Nitroarenes and Aldehydes

European Journal of Organic Chemistry, EarlyView.
A one‐pot Friedländer synthesis of 3‐substituted quinolines from readily available o‐nitrobenzaldehydes and aldehydes or acetals has been developed under dioxomolybdenum(VI) catalysis. Pinacol acts as a benign reductant, enabling in situ nitroarene reduction and annulation without isolation of o‐aminobenzaldehydes and provides access to diverse ...
Raúl Martínez‐González, María R. Pedrosa, Samuel Suárez‐Pantiga, Roberto Sanz   +3 more
wiley   +1 more source