Results 31 to 40 of about 4,070 (167)

Design, synthesis of N9- acyl substituted β-carboline derivatives containing 5-phenyl-2-furan moiety as potent anticancer agents

Results in Chemistry, 2022
β-Carbolines are of great interest due to their broad spectrum of biochemical effects and pharmaceutical functions, especially antitumor activity. The N9 position at β-carboline is a modification site for important antitumor activity. Several phenylfuran
Zhi Huang, Zhi-Kun Yang, Si-Qing Chen, Jian-Wei Chen, Xiao-Ze Bao, Xin-Yi Ye, Bin Wei, Zi-Ning Cui, Ya-Sheng Li, Hong Wang   +9 more
doaj   +1 more source

Self-immolative linkers in polymeric delivery systems [PDF]

, 2011
There has been significant interest in the methodologies of controlled release for a diverse range of applications spanning drug delivery, biological and chemical sensors, and diagnostics.
Blencowe, Christopher A, Greco, Francesca, Hayes, Wayne, Russell, Andrew T, Thornthwaite, David W   +4 more
core   +1 more source

Consecutive Four-Component Coupling-Addition Aza-Anellation Pictet–Spengler Synthesis of Tetrahydro-β-Carbolines: An Optimized Michael Addition and Computational Study on the Aza-Anellation Step

Organics, 2023
Starting from acid chlorides, alkynes, tryptamines, and acryloyl chloride, 21 densely substituted tetrahydro-β-carbolines were prepared in a four-component, one-pot reaction.
Kai Ries, Françoise A. Aouane, Thomas J. J. Müller   +2 more
doaj   +1 more source

Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
doaj   +1 more source

Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometry Combined With Fragmentation and Retention Time Calculation

Frontiers in Pharmacology, 2021
The stem of Picrasma quassioides (PQ) was recorded as a prominent traditional Chinese medicine, Kumu, which was effective for microbial infection, inflammation, fever, and dysentery, etc.
Haibo Hu, Haibo Hu, Changling Hu, Jinnian Peng, Alokesh Kumar Ghosh, Ajmal Khan, Dan Sun, Dan Sun, Walter Luyten   +8 more
doaj   +1 more source

Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes

Journal of Toxicology, 2011
Cigarette smoking and alcohol consumption possibly affect platelet functions. To verify the hypothesis that some α-, β-, and γ-carboline components in cigarette smoke and alcoholic beverages may change platelet aggregability, their effects on human ...
Hironori Tsuchiya
doaj   +1 more source

Drug-induced Parkinson's disease modulates protein kinase A and Olfactory Marker Protein in the mouse olfactory bulb [PDF]

, 2017
Background Olfaction is often affected in parkinsonian patients, but dopaminergic cells in the olfactory bulb are not affected by some Parkinson-inducing drugs.
Caretta, Antonio, Mucignat, Carla
core   +2 more sources

Computational Insights into β-Carboline Inhibition of Monoamine Oxidase A

Molecules, 2022
Monoamine oxidases (MAOs) are an important group of enzymes involved in the degradation of neurotransmitters and their imbalanced mode of action may lead to the development of various neuropsychiatric or neurodegenerative disorders.
Alja Prah, Tanja Gavranić, Andrej Perdih, Marija Sollner Dolenc, Janez Mavri   +4 more
doaj   +1 more source

Nicotinamide N-methyltransferase catalyses the N-methylation of the endogenous ß-carboline norharman: evidence for a novel detoxification pathway [PDF]

, 2016
Nicotinamide N-methyltransferase (NNMT) is responsible for the N-methylation of nicotinamide to 1-methylnicotinamide. Our recent studies have demonstrated that NNMT regulates cellular processes fundamental to the correct functioning and survival of the ...
Barlow, David J, Emanuelli, Monica, Klamt, Fábio, Martin, Nathaniel I, Mountford, David M, Parsons, Richard B, Ramsden, David B, Reza, Madeehah, Sartini, Davide, Thomas, Martin G, van Haren, Matthijs J   +10 more
core   +2 more sources

Effect of hydrogen bonding and complexation with metal ions on the fluorescence of luotonin A [PDF]

, 2013
Fluorescence characteristics of a biologically active natural alkaloid, luotonin A (LuA), were studied by steady-state and time-resolved spectroscopic methods.
Abraham, Abraham, Babu, Cagir, Carmona, Carmona, Cheng, Chou, Dallavalle, Dey, Dobkowski, Fung, Gonzalez-Ruiz, Gonzalez-Ruiz, Li, Liang, Lim, László Biczók, Ma, Maliakal, Marcus, Marcus, Marcus, Mason, Melhuish, Miskolczy, Miskolczy, Miskolczy, Miskolczy, Mussardo, Nagy, Nikolov, Peintler, Penedo, Reichardt, Reyman, Reyman, Sánchez-Coronilla, Takeuchi, Toele, Tseng, Vetokhina, Waluk, Yadav, Zhou, Zsombor Miskolczy   +45 more
core   +1 more source