Results 91 to 100 of about 886,342 (318)

Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin

Cellular Physiology and Biochemistry, 2018
Background/Aims: The epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a crucial event in the induction of peritoneal fibrosis (PF), in which canonical Wnt/β-catenin signaling participates.
Manshu Yu, Jun Shi, Meixiao Sheng, Kun Gao, Lu Zhang, Li Liu, Yilin Zhu   +6 more
doaj   +1 more source

Data_Sheet_1_Imbalanced Activation of Wnt-/β-Catenin-Signaling in Liver Endothelium Alters Normal Sinusoidal Differentiation.pdf

, 2021
Endothelial wingless-related integration site (Wnt)-/β-catenin signaling is a key regulator of the tightly sealed blood–brain barrier. In the hepatic vascular niche angiokine-mediated Wnt signaling was recently identified as an important regulator of ...
Christian D. Schmid (11498302), Sergij Goerdt (173750), Sina W. Kürschner (11498305), Cyrill Géraud (173717), Joerg Heineke (485790), Felix A. Trogisch (11498311), Joschka Heil (11498299), Johannes Hoffmann (6417659), Victor Olsavszky (11498314), Makoto Mark Taketo (10192985), Philipp-Sebastian Koch (6822989), Carsten Sticht (104859), Kajetan Sandorski (11498296), Theresa Staniczek (10999044), Manuel Winkler (11498308), Carolina de la Torre (9563074), Kai Schledzewski (173741)   +16 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

β-Catenin Controls the Electrophysiologic Properties of Skeletal Muscle Cells by Regulating the α2 Isoform of Na+/K+-ATPase

Frontiers in Neuroscience, 2019
β-Catenin is a key component of the canonical Wnt signaling pathway. It has been shown to have an important role in formation of the neuromuscular junction. Our previous studies showed that in the absence of β-catenin, the resting membrane potential (RMP)
Congying Zhao, Yonglin Yu, Yi Zhang, Jue Shen, Lihua Jiang, Guoxia Sheng, Weiqin Zhang, Lu Xu, Kewen Jiang, Kewen Jiang, Kewen Jiang, Shanshan Mao, Shanshan Mao, Peifang Jiang, Feng Gao   +14 more
doaj   +1 more source

MOESM2 of JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway

, 2019
Additional file 2: Figure S2. JMJD2C promoted the proliferation of CRC HCT116 cells, but affected little on the apoptosis of the indicated cells. a MTT assay of HCT116 cells transfected with shRNA/NT, shRNA/JMJD2C, empty vector, or JMJD2C overexpression vector, respectively.
Wu, Xinnan, Li, Ruixiao, Song, Qing, Zhang, Chengcheng, Jia, Ru, Han, Zhifen, Zhou, Lihong, Sui, Hua, Liu, Xuan, Zhu, Huirong, Yang, Liu, Wang, Yan, Ji, Qing, Li, Qi   +13 more
openaire   +1 more source

An examination of VEGF, its receptors and the adherens junction component, β-catenin in the development of primary varicose veins

, 2010
Vascular endothelial growth factor (VEGF-A) plays a central role in the maintenance of vascular reactivity and its aberrant control/function is implicated in the development of varicose veins (VVs).
Powell, G.L.
core  

Table_1_SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition.DOC

, 2018
SIRT6 is involved in various cellular signaling pathways including those involved in tumorigenesis in association with β-catenin. However, the role of SIRT6 in tumorigenesis has been controversially reported and the studies on the role of SIRT6 in ...
Sang Hoon Ha (834619), Ho Lee (453255), Myoung Ja Chung (453256), Byung-Hyun Park (518987), Ho Sung Park (134939), Woo Sung Moon (134941), Usama Khamis Hussein (5989955), Kyoung Min Kim (436671), Kyu Yun Jang (134932), Sang Jae Noh (134934), Jun Sang Bae (453251), See-Hyoung Park (246508), Dong Hyu Cho (5989958)   +12 more
core   +1 more source

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]

, 2011
The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M., Leung, H.Y., Hing Y. Leung, Wu, X.-R., Iwata, T., Mona Foth, Morris, C.-A., Owen J. Sansom, Lukram Babloo Singh, Tomoko Iwata, Imran Ahmad, Carol-Ann Morris, Makoto Mark Taketo, Singh, L.B., Foth, M., Sansom, O.J., Xue-Ru Wu, Ahmad, I.   +17 more
core   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

MOESM1 of LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

, 2019
Additional file 1: Figure S1.Overview image of immunofluorescence staining (GFAP+) in SCI animal models at 1 and 2 weeks post-injury were shown.
Cui, Yi, Yin, Yanyun, Xiao, Zhifeng, Zhao, Yannan, Chen, Bing, Yang, Bin, Xu, Bai, Song, Hongwei, Zou, Yunlong, Ma, Xu, Dai, Jianwu   +10 more
openaire   +1 more source