Results 91 to 100 of about 262,733 (310)

β-Catenin Controls the Electrophysiologic Properties of Skeletal Muscle Cells by Regulating the α2 Isoform of Na+/K+-ATPase

Frontiers in Neuroscience, 2019
β-Catenin is a key component of the canonical Wnt signaling pathway. It has been shown to have an important role in formation of the neuromuscular junction. Our previous studies showed that in the absence of β-catenin, the resting membrane potential (RMP)
Congying Zhao, Yonglin Yu, Yi Zhang, Jue Shen, Lihua Jiang, Guoxia Sheng, Weiqin Zhang, Lu Xu, Kewen Jiang, Kewen Jiang, Kewen Jiang, Shanshan Mao, Shanshan Mao, Peifang Jiang, Feng Gao   +14 more
doaj   +1 more source

Additional file 8: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S1. Clinicopathological characteristics of 102 HCC patients. (DOC 38 kb)
Deng, Ling, Jingyuan Sun, Xiaohui Chen, Liu, Li, Dehua Wu   +4 more
openaire   +1 more source

Activation of phosphatidylinositol 3-kinase/Akt signaling by EGF downregulates membranous E-cadherin and â-catenin and enhances invasion in nasopharyngeal carcinoma cells. [PDF]

, 2012
Dysregulation of E-cadherin and β-catenin function in cell-cell adhesion is common in nasopharyngeal carcinoma (NPC) and correlates with metastatic disease.
Seow, Heng Fong, Wai, Kien Yip
core   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

MOESM2 of JMJD2C promotes colorectal cancer metastasis via regulating histone methylation of MALAT1 promoter and enhancing β-catenin signaling pathway

, 2019
Additional file 2: Figure S2. JMJD2C promoted the proliferation of CRC HCT116 cells, but affected little on the apoptosis of the indicated cells. a MTT assay of HCT116 cells transfected with shRNA/NT, shRNA/JMJD2C, empty vector, or JMJD2C overexpression vector, respectively.
Wu, Xinnan, Li, Ruixiao, Song, Qing, Zhang, Chengcheng, Jia, Ru, Han, Zhifen, Zhou, Lihong, Sui, Hua, Liu, Xuan, Zhu, Huirong, Yang, Liu, Wang, Yan, Ji, Qing, Li, Qi   +13 more
openaire   +1 more source

Dominant β-catenin mutations cause intellectual disability with recognizable syndromic features [PDF]

, 2014
The recent identification of multiple dominant mutations in the gene encoding β-catenin in both humans and mice has enabled exploration of the molecular and cellular basis of β-catenin function in cognitive impairment. In humans, β-catenin mutations that
Alessandro Gozzi, Alessandro Maccione, Andrea Contestabile, Andrea Hardy, Andrea Raimondi, Angelo Bifone, Anneke T. Vulto-van Silfhout, Barbara Greco, Campos, Chiappalone, Chris Esapa, Daniela Cantatore, Federico Tinarelli, Glenda Lassi, Helen Hilton, Ines Heise, Laura Gasparini, Liam J. McGuffin, Lisenka E.L.M. Vissers, Luca Berdondini, Luca Dodero, Lucie Vizor, Maria-Teresa Buenavista, Marjolein H. Willemsen, Marlies J. Kempers, Marta Orlando, Michelle Simon, Pasqualina Farisello, Patrick M. Nolan, Rosario Romero, Sara Wells, Silvia Maggi, Sotirios Tsaftaris, Thierry Nieus, Tjitske Kleefstra, Valter Tucci, Vandesompele, Willy N. Nillesen, Zafar Iqbal   +38 more
core   +3 more sources

Paracrine Factor Local Gradient‐Generating System for Engineering Perfusable Vascularized Hepatocyte Tissues with Perfusion‐Induced Proliferation

Advanced Healthcare Materials, EarlyView.
A paracrine factor local gradient (PFLG)‐generating system enables microvessel penetration across 3D hepatocyte tissues. The resulting vascularized constructs recapitulate hepatic sinusoidal hepatocyte—endothelial contact architecture and enhance hepatic functions in vitro.
Yen‐Hsiang Huang, Tadahiro Yamashita, Ryo Sudo   +2 more
wiley   +1 more source

Additional file 3 of β-Catenin nuclear localization positively feeds back on EGF/EGFR-attenuated AJAP1 expression in breast cancer

, 2019
Table S3. Cox proportional hazard regression model analysis. (DOC 36 kb)
Xu, Cong, Liu, Fang, Xiang, Guomin, Cao, Lu, Wang, Shuling, Liu, Jing, Meng, Qingxiang, Xu, Danni, Lv, Shuhua, Jiao, Jiao, Niu, Yun   +10 more
openaire   +1 more source

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin. [PDF]

, 2017
Cellular proliferation is antagonistically regulated by canonical and noncanonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the noncanonical Wnt ...
Aznar, Nicolas, Buschman, Matthew D, Dunkel, Ying, Ear, Jason, Ghosh, Pradipta, Sun, Nina   +5 more
core   +3 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source