Results 71 to 80 of about 886,342 (318)

Additional file 1: of Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma

, 2018
Supplementary experiments and routine methods. Figure S1. Spheroid formation capability of HCC cell lines. Figure S2. β-catenin expression in HepG2 cell line. Figure S3. Knockdown efficiency of siRNA transfection. Routine Methods: Immunocytochemistry (ICC) Staining, Flow-Cytometry Analysis, Protein Extraction and Western Blot. Table S1.
Pandit, Harshul, Li, Yan, Li, Xuanyi, Zhang, Weizhong, Li, Suping, Martin, Robert   +5 more
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Additional file 10: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S3. Univariate and multivariate analyses of OS in 102 HCC patients by Cox regression analysis. (DOCX 14 kb)
Deng, Ling, Sun, Jingyuan, Chen, Xiaohui, Liu, Li, Wu, Dehua   +4 more
openaire   +1 more source

A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration

, 2014
By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin constitutes the lynchpin between cell:cell contact and transcriptional regulation of proliferation to co-ordinate epithelial tissue homeostasis and ...
Kirkwood, Lisa A., Southgate, Jennifer, Georgopoulos, Nikolaos T.   +2 more
core   +1 more source

DataSheet1_CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis via β-Catenin-Induced Mitochondrial Dysfunction.docx

, 2022
Renal fibrosis is a common feature of various chronic kidney diseases (CKD). However, its underlying mechanism has not been totally clarified. C-X-C motif chemokine receptor (CXCR) family plays a role in renal fibrosis, however, detailed mechanisms have ...
Jingyan Wei (1716046), Lili Zhou (265076), Weiwei Shen (750987), Yunfang Zhang (585611), Mingsheng Zhu (286113), Jinhua Miao (12177029), Jiemei Li (9116858), Jiewu Huang (11899382), Ping Meng (250328), Huiyun Ye (12491425), Xian Ling (12491422), Hongxin Niu (12491428), Shan Zhou (112166)   +12 more
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Additional file 1: Table S1. of PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

, 2017
The clinicopathologic characteristics of the patients with 30 NSCLC participants employed for qRT-PCR assay of PRC1 mRNA expression. Table S2. The primers used in qPCR analysis. Table S3. The relative information on the antibodies in our study. (DOCX 26Â kb)
Zhan, Ping, Zhang, Bin, Xi, Guang-Min, Wu, Ying, Liu, Hong-Bing, Liu, Ya-Fang, Wu-Jian Xu, Zhu, Qing-Qing, Cai, Feng, Zhou, Ze-Jun, Miu, Ying-Ying, Wang, Xiao-Xia, Jin, Jia-Jia, Li, Qian, Qian, Li-Ping, Tang-Feng Lv, Song, Yong   +16 more
openaire   +1 more source

Glycogen synthase kinase 3-β inhibition induces lymphangiogenesis through β-catenin-dependent and mTOR-independent pathways

, 2019
Lymphatic vessels play an important role in health and in disease. In this study, we evaluated the effects of GSK3-β inhibition on lung lymphatic endothelial cells in vitro.
Rosas, Ivan O, El-Chemaly, Souheil, Stump, Benjamin, Carmen Priolo (396611), Woohyun Cho (6569486), Astin, Jonathan, Ai, Xingbin, Ivan O. Rosas (315478), Shikshya Shrestha (6569477), Shrestha, Shikshya, Anthony M. Lamattina (6569480), Jonathan Astin (6569489), Louis, Pierce H, Priolo, Carmen, Souheil El-Chemaly (705219), Benjamin Stump (6569474), Florence F. Wagner (445656), Lamattina, Anthony M, Perrella, Mark A, Pierce H. Louis (6569483), Mark A. Perrella (364790), Xingbin Ai (456360), Cho, Woohyun, Wagner, Florence F   +23 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Additional file 1: of Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

, 2019
Table S1. Mouse oligonucleotide primers used for real time RT-PCR. Table S2. Human oligonucleotide primers used for real time RT-PCR. (DOC 34 kb)
Lee, Dong, Park, Mi, Hwang, Chul, Kim, Youngsoo, Hwang, Dae, Han, Sang, Hong, Jin   +6 more
openaire   +1 more source