Results 51 to 60 of about 262,733 (310)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish

Biology Open, 2019
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and ...
Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young, Kimberley J. Evason   +5 more
doaj   +1 more source

Stabilisation of β-catenin downstream of T cell receptor signalling. [PDF]

PLoS ONE, 2010
The role of TCF/β-catenin signalling in T cell development is well established, but important roles in mature T cells have only recently come to light.Here we have investigated the signalling pathways that are involved in the regulation of β-catenin in ...
Matthew Lovatt, Marie-José Bijlmakers
doaj   +1 more source

APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. [PDF]

, 2020
Sporadic colorectal cancer initiates with mutations in APC or its degradation target β-catenin, producing TCF-dependent nuclear transcription driving tumorigenesis. The intestinal epithelial receptor, GUCY2C, with its canonical paracrine hormone guanylin,
Bashir, Babar, Blomain, Erik S, Caparosa, Ellen, Pattison, Amanda M, Rappaport, Jeffrey A, Snook, Adam E, Stem, Jonathan, Waldman, Scott A   +7 more
core   +1 more source

Synaptic Wnt/GSK3β Signaling Hub in Autism [PDF]

, 2016
Indexación: ScopusHundreds of genes have been associated with autism spectrum disorders (ASDs) and the interaction of weak and de novo variants derive from distinct autistic phenotypes thus making up the "spectrum." The convergence of these variants in ...
Avila, M.E., Caracci, M.O., De Ferrari, G.V.   +2 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis. [PDF]

, 2020
Mechanisms underpinning airway epithelial homeostatic maintenance and ways to prevent its dysregulation remain elusive. Herein, we identify that β-catenin phosphorylated at Y489 (p-β-cateninY489) emerges during human squamous lung cancer progression ...
Aros, Cody J, Bisht, Bharti, Chen, Michelle W, Damoiseaux, Robert, France, Bryan, Gomperts, Brigitte N, Meneses, Luisa K, Pantoja, Carla J, Paul, Manash K, Rickabaugh, Tammy M, Sandlin, Jenna M, Shia, David W, Tse, Jonathan A, Vijayaraj, Preethi   +13 more
core   +1 more source

Transcriptional activity mediated by β-CATENIN and TCF/LEF family members is completely dispensable for survival and propagation of multiple human colorectal cancer cell lines

Scientific Reports, 2023
Unrestrained transcriptional activity of β-CATENIN and its binding partner TCF7L2 frequently underlies colorectal tumor initiation and is considered an obligatory oncogenic driver throughout intestinal carcinogenesis.
Janna Fröhlich, Katja Rose, Andreas Hecht   +2 more
doaj   +1 more source

Additional file 1: of Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation

, 2019
Table S1. Mouse oligonucleotide primers used for real time RT-PCR. Table S2. Human oligonucleotide primers used for real time RT-PCR. (DOC 34 kb)
Lee, Dong, Park, Mi, Hwang, Chul, Youngsoo Kim, Hwang, Dae, Han, Sang, Hong, Jin   +6 more
openaire   +1 more source

p53 mutation as a source of aberrant β-catenin accumulation in cancer cells [PDF]

, 2002
β-catenin is involved in both cell-cell interactions and wnt pathway-dependent cell fate determination through its interactions with E-cadherin and TCF/LEF transcription factors, respectively.
Cagatay, T., Ozturk, M.
core   +1 more source