Results 41 to 50 of about 262,733 (310)
World Journal of Surgical Oncology, 2007 Background β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. β-catenin is involved in Wnt signaling pathway that regulates cellular differentiation and proliferation.
Shinoda Noriyuki +10 more
doaj +1 more source
Phosphorylated Tyr142 β-catenin localizes to centrosomes and is regulated by Syk [PDF]
, 2018 β-catenin is a central component of adherent junctions and a key effector of canonical Wnt signalling, in which dephosphorylated Ser/Thr β-catenin regulates gene transcription.
Bhardwaj, Deepshikha +6 more
core +3 more sources
The nucleolar protein NIFK promotes cancer progression via CK1α/β-catenin in metastasis and Ki-67-dependent cell proliferation. [PDF]
, 2016 Nucleolar protein interacting with the FHA domain of pKi-67 (NIFK) is a Ki-67-interacting protein. However, its precise function in cancer remains largely uninvestigated.
Chang, Hong-Tai +17 more
core +2 more sources
PLoS Biology, 2020 Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood.
Mudan He +6 more
doaj +1 more source
A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. [PDF]
PLoS ONE, 2011 The Wnt/β-catenin signalling pathway shares a key component, β-catenin, with the cadherin-based adhesion system. The signalling function of β-catenin is conferred by a soluble cytoplasmic pool that is unstable in the absence of a Wnt signal, whilst the ...
Sara Howard +3 more
doaj +1 more source
Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells. [PDF]
, 2017 β-catenin has two different cellular functions: intercellular adhesion and transcriptional activity. The E3 ubiquitin ligase Siah1 causes ubiquitin-mediated degradation of the cytosolic β-catenin and therefore, impairs nuclear translocation and oncogenic
Bhattacharyya, A +7 more
core +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The role of β-catenin in tooth development
AL-QADISIYAH MEDICAL JOURNAL, 2017 Background:The present experimental study was conducted on tooth development during embryogenesis in developing mouse. with main objective to identify the expression and action β -Catenin in development of teeth and mophogenesis. Materials and Methods:This study comprised a total of (21) sections were selected during different stages of tooth ...
openaire +1 more source
, 2018 Figure S1. Upregulation of Wnt signaling leads to proliferation of human ES cell-derived cardiomyocytes. Figure S2. Expression levels of Wnt signaling genes are affected in a cardiac hypertrophy model. Table S1. Lists of human and murine primer sequences used in this study. (DOCX 167 kb)
Fan, Yong +6 more
openaire +1 more source
, 2023 <p>PKCÎ'-silenced PC3 (a) and LNCaP (b) cells were treated with DMSO or paclitaxel 2.5 µM 48 hours. Histograms show densitometric and statistical analysis of indicated proteins from panels (c) and (d) of the Figure 3. Data are presented as mean{plus minus}S.E.M.
Carmen Sáez +7 more
openaire +1 more source