Results 41 to 50 of about 886,342 (318)

Heterogeneous beta-catenin activation is sufficient to cause hepatocellular carcinoma in zebrafish

Biology Open, 2019
Up to 41% of hepatocellular carcinomas (HCCs) result from activating mutations in the CTNNB1 gene encoding β-catenin. HCC-associated CTNNB1 mutations stabilize the β-catenin protein, leading to nuclear and/or cytoplasmic localization of β-catenin and ...
Sharanya M. Kalasekar, Srishti Kotiyal, Christopher Conley, Cindy Phan, Annika Young, Kimberley J. Evason   +5 more
doaj   +1 more source

Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors.

PLoS Biology, 2020
Maternal β-catenin activity is essential and critical for dorsal induction and its dorsal activation has been thoroughly studied. However, how the maternal β-catenin activity is suppressed in the nondorsal cells remains poorly understood.
Mudan He, Ru Zhang, Shengbo Jiao, Fenghua Zhang, Ding Ye, Houpeng Wang, Yonghua Sun   +6 more
doaj   +1 more source

A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. [PDF]

PLoS ONE, 2011
The Wnt/β-catenin signalling pathway shares a key component, β-catenin, with the cadherin-based adhesion system. The signalling function of β-catenin is conferred by a soluble cytoplasmic pool that is unstable in the absence of a Wnt signal, whilst the ...
Sara Howard, Tom Deroo, Yasuyuki Fujita, Nobue Itasaki   +3 more
doaj   +1 more source

The role of β-catenin in tooth development

AL-QADISIYAH MEDICAL JOURNAL, 2017
Background:The present experimental study was conducted on tooth development during embryogenesis in developing mouse. with main objective to identify the expression and action β -Catenin in development of teeth and mophogenesis. Materials and Methods:This study comprised a total of (21) sections were selected during different stages of tooth ...
openaire   +1 more source

Additional file 1: of Wnt/β-catenin-mediated signaling re-activates proliferation of matured cardiomyocytes

, 2018
Figure S1. Upregulation of Wnt signaling leads to proliferation of human ES cell-derived cardiomyocytes. Figure S2. Expression levels of Wnt signaling genes are affected in a cardiac hypertrophy model. Table S1. Lists of human and murine primer sequences used in this study. (DOCX 167 kb)
Fan, Yong, Ho, Beatrice, Pang, Jeremy, Pek, Nicole, Hor, Jin, Ng, Shi-Yan, Soh, Boon-Seng   +6 more
openaire   +1 more source

Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression

, 2012
Endothelial Wnt/β-catenin signaling is necessary for angiogenesis of the central nervous system and blood–brain barrier (BBB) differentiation, but its relevance for glioma vascularization is unknown. In this study, we show that doxycycline-dependent Wnt1
Devraj, Kavi, Nicole Ziegler, Fruttiger, Marcus, Rosario Heck, Sascha Seidel, Sonja Thom, Taketo, Makoto Mark, Kavi Devraj, Seidel, Sascha, Karl H. Plate, Liebner, Stefan, Reis, Marco, Bockamp, Ernesto, Heck, Rosario, Ernesto Bockamp, Marco Reis, Cathrin J. Czupalla, Makoto M. Taketo, Thom, Sonja, Zinke, Jenny, Plate, Karl, Macas, Jadranka, Jenny Zinke, Czupalla, Cathrin Jacqueline, Jadranka Macas, Stefan Liebner, Stefanie Dimmeler, Dimmeler, Stefanie, Ziegler, Nicole, Marcus Fruttiger   +29 more
core   +1 more source

β-catenin expression in perilesional area of different grades of oral squamous cell carcinoma [PDF]

, 2016
Objectives: Background: Multistep carcinogenesis discusses a stepwise accumulation of alterations, both genotypic and phenotypic. Arresting one or several of the steps may disturb or delay the development of cancer.
Marwa A. Hamied
core   +1 more source

Table3_Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells.xlsx

, 2023
Introduction: Wnt/β-catenin signaling controls cell division and lineage specification during embryonic development, and is crucial for stem cells maintenance and gut tissue regeneration in adults.
Irina Elcheva (3844003), Vonn Walter (165501), Vladimir S. Spiegelman (10308404), Yuka Imamura Kawasawa (7254923), Vikash Singh (387413)   +4 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Nemo kinase phosphorylates β-catenin to promote ommatidial rotation and connects core PCP factors to E-cadherin–β-catenin

, 2011
Frizzled planar cell polarity (PCP) signaling regulates cell motility in several tissues, including ommatidial rotation in Drosophila melanogaster. The Nemo kinase (Nlk in vertebrates) has also been linked to cell-motility regulation and ommatidial ...
Cara J Gottardi, Konstantin Gaengel, Gaengel, Konstantin, Gottardi, Cara J., Andreas Jenny, Darrell Bessette, Mlodzik, Marek, Gault, William J., Ivana Mirkovic, Esther M Verheyen, Marek Mlodzik, Jenny, Andreas, Bessette, Darrell C., Rahnama, Maryam, William J Gault, Maryam Rahnama, Verheyen, Esther M., Mirkovic, Ivana   +17 more
core   +1 more source