Results 31 to 40 of about 1,062,506 (300)

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Journal of Translational Medicine, 2023
Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang   +8 more
doaj   +1 more source

MOESM8 of Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway

, 2020
Additional file 8: Table S2. The qRT-PCR sequences of primers.
Feng, Yun, Wang, Linlin, Ma, Xiaoying, Yang, Xiaotong, Don, Ocholi, Chen, Xiaoyan, Qu, Jieming, Song, Yuanlin   +7 more
openaire   +1 more source

Transient Expression of WNT2 Promotes Somatic Cell Reprogramming by Inducing β-Catenin Nuclear Accumulation

Stem Cell Reports, 2016
Summary: Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramming efficiency; however, the dynamics and role of endogenous Wnt/β-catenin signaling in reprogramming remain largely unanswered. Here we identify
Mizuki Kimura, May Nakajima-Koyama, Joonseong Lee, Eisuke Nishida   +3 more
doaj   +1 more source

The FAM deubiquitylating enzyme localizes to multiple points of protein trafficking in epithelia, where it associates with E-cadherin and beta-catenin [PDF]

, 2004
Copyright © 2004 by The American Society for Cell Biology.Ubiquitylation is a necessary step in the endocytosis and lysosomal trafficking of many plasma membrane proteins and can also influence protein trafficking in the biosynthetic pathway.
Murray, Rachael, Murray, RZ, Wood, S., Wood, SA, Wood, Stephen J., Jolly, LA, A. Jolly, Lachlan, A. Wood, Stephen, Jolly, Lachlan, Murray, R., Jolly, L., Z. Murray, Rachael   +11 more
core   +2 more sources

Amyloid precursor protein modulates β-catenin degradation

Journal of Neuroinflammation, 2007
Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj   +1 more source

Dynamics of Wnt/β-catenin signalling during cerebellum development [PDF]

, 2012
Medulloblastomas are tumours of cerebellar origin and are thought to arise from the malignant transformation of progenitor cells in the developing cerebellum. A number of developmental signalling pathways are required for the precise cell specification,
Selvadurai, Hayden John
core   +3 more sources

Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]

, 2012
Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W., Armstrong Neil J., Fagotto François, Christian Prothmann, Ralph A W Rupp, Prothmann, Christian, Neil J Armstrong, Rupp Ralph A. W., François Fagotto, Prothmann Christian, Fagotto, François, Armstrong, Neil J.   +11 more
core   +2 more sources

Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas

The Scientific World Journal, 2012
Aberrant wnt pathway activation through cytoplasmic stabilization of β-catenin is crucial for the development of various human malignancies. In gliomagenesis, the role of canonical (i.e., β-catenin-dependent) signalling is largely unknown.
Rebecca Schüle, Christine Dictus, Benito Campos, Feng Wan, Jörg Felsberg, Rezvan Ahmadi, Franz-Simon Centner, Niels Grabe, Guido Reifenberger, Justo L. Bermejo, Andreas Unterberg, Christel Herold-Mende   +11 more
doaj   +1 more source

γ-Catenin at Adherens Junctions: Mechanism and Biologic Implications in Hepatocellular Cancer after β-Catenin Knockdown

Neoplasia: An International Journal for Oncology Research, 2013
β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline, Yu Du, Donna B. Stolz, Michael Kahn, Satdarshan P.S. Monga   +4 more
doaj   +1 more source

MOESM7 of Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway

, 2020
Additional file 7: Table S1. The siRNA sequences of GLP-1R and TCF-4.
Feng, Yun, Wang, Linlin, Ma, Xiaoying, Yang, Xiaotong, Don, Ocholi, Chen, Xiaoyan, Qu, Jieming, Song, Yuanlin   +7 more
openaire   +1 more source