Results 31 to 40 of about 262,733 (310)

β-Catenin regulates endocardial cushion growth by suppressing p21

Life Science Alliance, 2023
This work demonstrates that β-catenin–mediated suppression of p21 is essential for endocardial cushion formation, suggesting a potential role of β-catenin in the etiology of congenital heart defects.
Huahua Liu, Pengfei Lu, Shan He, Yuru Luo, Yuan Fang, Sonia Benkaci, Bingruo Wu, Yidong Wang, Bin Zhou   +8 more
doaj   +1 more source

Deletion of a Single beta-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading [PDF]

, 2014
The Wnt/β-catenin signaling pathway is essential for bone cell viability and function and for skeletal integrity. To determine if β-catenin in osteocytes plays a role in the bone anabolic response to mechanical loading, 18- to 24-week-old osteocyte β ...
Akhter, Armstrong, Armstrong, Babij, Bodine, Bodine, Bonewald, Bouxsein, Boyden, Case, Choi, Dallas, Dempster, Diarra, Doube, Galea, Glass, Gong, Hens, Holmen, Holmen, Javaheri, Johnson, Johnson, Johnson, Kamel, Kato, Kitase, Korecki, Kramer, Lau, Li, Little, Logan, Lu, Monga, Nakashima, Nathke, Nusse, Pinson, Polakis, Reya, Robinson, Santos, Sawakami, Saxon, Schneider, Sen, Srivastava, Sunters, Wijenayaka, Xing, Xiong, Yao   +53 more
core   +2 more sources

Unsaturated Fatty Acids Stimulate Tumor Growth through Stabilization of β-Catenin

Cell Reports, 2015
Some cancer cells exhibit elevated levels of free fatty acids (FAs) as well as high levels of β-catenin, a transcriptional co-activator that promotes their growth. Here, we link these two phenomena by showing that unsaturated FAs inhibit degradation of β-
Hyeonwoo Kim, Carlos Rodriguez-Navas, Rahul K. Kollipara, Payal Kapur, Ivan Pedrosa, James Brugarolas, Ralf Kittler, Jin Ye   +7 more
doaj   +1 more source

Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells. [PDF]

PLoS ONE, 2011
Metastatic melanoma is a leading cause of death from skin diseases, and is often associated with activation of Wnt/β-catenin signaling pathway. We have examined the inhibitory effect of silymarin, a plant flavanoid from Silybum marianum, on cell ...
Mudit Vaid, Ram Prasad, Qian Sun, Santosh K Katiyar   +3 more
doaj   +1 more source

MOESM7 of Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway

, 2020
Additional file 7: Table S1. The siRNA sequences of GLP-1R and TCF-4.
Feng, Yun, Linlin Wang, Xiaoying Ma, Xiaotong Yang, Ocholi Don, Xiaoyan Chen, Jieming Qu, Yuanlin Song   +7 more
openaire   +1 more source

Ixazomib enhances parathyroid hormone-induced β-catenin/T-cell factor signaling by dissociating β-catenin from the parathyroid hormone receptor. [PDF]

, 2017
The anabolic action of PTH in bone is mostly mediated by cAMP/PKA and Wnt-independent activation of β-catenin/T-cell factor (TCF) signaling. β-Catenin switches the PTH receptor (PTHR) signaling from cAMP/PKA to PLC/PKC activation by binding to the PTHR ...
Lei, Hong, Qiang, Ya-Wei, Wang, Bin, Yang, Yanmei   +3 more
core   +2 more sources

Ectopic γ-catenin expression partially mimics the effects of stabilized β-catenin on embryonic stem cell differentiation. [PDF]

PLoS ONE, 2013
β-catenin, an adherens junction component and key Wnt pathway effector, regulates numerous developmental processes and supports embryonic stem cell (ESC) pluripotency in specific contexts.
Sujeivan Mahendram, Kevin F Kelly, Sabrina Paez-Parent, Sharmeen Mahmood, Enio Polena, Austin J Cooney, Bradley W Doble   +6 more
doaj   +1 more source

MOESM8 of Effect of hCMSCs and liraglutide combination in ALI through cAMP/PKAc/β-catenin signaling pathway

, 2020
Additional file 8: Table S2. The qRT-PCR sequences of primers.
Feng, Yun, Linlin Wang, Xiaoying Ma, Xiaotong Yang, Ocholi Don, Xiaoyan Chen, Jieming Qu, Yuanlin Song   +7 more
openaire   +1 more source

Wnt/β-catenin signaling stimulates the expression and synaptic clustering of the autism-associated Neuroligin 3 gene [PDF]

, 2018
Indexación: Scopus.Synaptic abnormalities have been described in individuals with autism spectrum disorders (ASD). The cell-adhesion molecule Neuroligin-3 (Nlgn3) has an essential role in the function and maturation of synapses and NLGN3 ASD-associated ...
Andrade, V.M., Avila, M.E., Caracci, M.O., De Ferrari, G.V., Medina, M.A., Opazo, C., Reyes, A.E., Ugarte, G.D., Vargas, M.F., Verdugo, D.A.   +9 more
core   +1 more source

Differentiation Therapy Targeting the β-Catenin/CBP Interaction in Pancreatic Cancer. [PDF]

, 2018
BACKGROUND:Although canonical Wnt signaling is known to promote tumorigenesis in pancreatic ductal adenocarcinoma (PDAC), a cancer driven principally by mutant K-Ras, the detailed molecular mechanisms by which the Wnt effector β-catenin regulates such ...
Chen, Yibu, Genyk, Yuri S, Kahn, Michael, Lai, Keane KY, Lenz, Heinz-Josef, Lin, David P, Manegold, Philipp, Nguyen, Cu, Pandol, Stephen J, Teo, Jia-Ling, Wu, Kaijin, Wu, Yongfeng, Zhao, Yi   +12 more
core   +2 more sources