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Comprehensive proximity proteomics expand the known interactome of the oncoprotein β-catenin [PDF]
Scientific ReportsThe oncoprotein β-catenin has critical roles in cell adhesion and cell signalling. β-catenin affects human physiology and pathology through numerous interaction partners, of which many have been discovered by standard affinity purification-based ...
Lavanya Moparthi +2 more
doaj +2 more sources
Prostate cancer stem cell fate: β-catenin and the Wnt pathway [PDF]
, 2010 A major problem in prostate cancer is the high relapse rate post therapy. This is believed to be due to the presence of a small number of prostate cancer stem cells within a tumour.
Jakoby, Sarah
core +6 more sources
Modulation of miR-23b Wnt/β-catenin Axis Strengthens Endothelial Barrier Properties. [PDF]
Adv Sci (Weinh)Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Martinez VA +16 more
europepmc +2 more sources
Study of β-Catenin as Immunohistochemistry Marker in Women with Breast Cancer
Iraqi Journal of Science, 2021 Background & Objective: Breast cancer (BC) is the most prevalent disease among women around the world, considered the world's leading cause of death (15% of the total cancer deaths) in women in 2018. β-catenin is a multifunctional protein located in the cytoplasm and/or nucleus of the cell.
Ruqayah Ali Salman +2 more
openaire +2 more sources
Discovery of novel small molecule activators of β-catenin signaling. [PDF]
PLoS ONE, 2011 Wnt/β-catenin signaling plays a major role in embryonic development and adult stem cell maintenance. Reduced activation of the Wnt/β-catenin pathway underlies neurodegenerative disorders and aberrations in bone formation.
Folkert Verkaar +4 more
doaj +1 more source
β-Catenin expression is associated with cell invasiveness in pancreatic cancer [PDF]
The Korean Journal of Internal Medicine, 2019 Background/Aims This study was tried to determine the role of β-catenin in invasion in pancreatic cancer. Methods We analyzed cancer invasiveness according to β-catenin expression in pancreatic cancer cell line.
Jin Niang Nan, Ok Ran Kim, Myung Ah Lee
doaj +1 more source
TRAIP Mediates Alcohol-Induced Liver Injury through Regulating β-catenin Ubiquitin Degradation via Direct Interaction. [PDF]
Adv Sci (Weinh)This study reveals that NF‐κB1‐driven TRAIP upregulation in ALD correlates with disease severity. Mechanistically, TRAIP directly binds β‐catenin via its CC domain and promotes its K48‐linked ubiquitination and degradation, which is independent of the GSK3β/β‐TrCP pathway.
Wu Z +13 more
europepmc +2 more sources
Frontiers in Oncology, 2022 Casein kinase 1δ/ϵ (CK1δ/ϵ) are well-established positive modulators of the Wnt/β-catenin signaling pathway. However, the molecular mechanisms involved in the regulation of β-catenin transcriptional activity by CK1δ/ϵ remain unclear.
Jiong Ning +13 more
doaj +1 more source
Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway [PDF]
, 2023 A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated from patients ...
Miyoshi, Mana +9 more
core +1 more source
BMC Cancer, 2018 Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcinogenesis.
Yu Qiao +7 more
doaj +1 more source