Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis [PDF]
eLife, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Blair W Benham-Pyle +4 more
doaj +4 more sources
Correlation between β-catenin mutations and expression of Wnt-signaling target genes in hepatocellular carcinoma [PDF]
Molecular Cancer, 2008 Aberrant Wnt-signaling caused by mutants of β-catenin, a key regulator of the canonical Wnt-signaling pathway, is frequently detected in cancer. Only recently, it was suggested that in hepatocellular carcinoma (HCC) the expression of the target gene ...
Gebhardt Rolf +5 more
doaj +3 more sources
Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes. [PDF]
, 2016 Mu-protocadherin (MUCDHL) is an adhesion molecule predominantly expressed by colorectal epithelial cells which is markedly downregulated upon malignant transformation.
Calabretta, Bruno +11 more
core +2 more sources
E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]
, 2015 Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke +27 more
core +2 more sources
Smad7:β-catenin Complex Regulates Myogenic Gene Transcription [PDF]
, 2019 Recent reports indicate that Smad7 promotes skeletal muscle differentiation and growth. We previously documented a non-canonical role of nuclear Smad7 during myogenesis, independent of its role in TGF-β signaling.
McDermott, John +2 more
core +1 more source
β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB
Cancer Cell International, 2020 Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu +6 more
doaj +1 more source
Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]
, 2014 In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Azim, Kasum +8 more
core +1 more source
Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway
BMC Veterinary Research, 2020 Background Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle.
Xinying Du +3 more
doaj +1 more source
Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]
PLoS ONE, 2010 The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux +4 more
doaj +1 more source
Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling [PDF]
, 2012 Tissue inhibitor of metalloproteinases 1 (TIMP-1) is a matrix metalloproteinase (MMP)-independent regulator of growth and apoptosis in various cell types.
Avalos +42 more
core +1 more source