Results 11 to 20 of about 886,342 (318)

Anti-nucleolin aptamer, iSN04, inhibits the inflammatory responses in C2C12 myoblasts by modulating the β-catenin/NF-κB signaling pathway [PDF]

, 2023
A myogenetic oligodeoxynucleotide, iSN04, is the 18-base single-stranded DNA that acts as an anti-nucleolin aptamer. iSN04 has been reported to restore myogenic differentiation by suppressing inflammatory responses in myoblasts isolated from patients ...
Miyoshi, Mana, Takaya, Tomohide, Takakazu Mitani, Tomohide Takaya, Morioka, Kamino, Machi Yamamoto, Mana Miyoshi, Yamamoto, Machi, Mitani, Takakazu, Kamino Morioka   +9 more
core   +1 more source

Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]

, 2012
Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes, Peröbner, Iris, Capovilla, Simon, Neth, Peter, Fernsebner, Katharina, Lechner, F., Jochum, M., Neth, P., Kolben, Thomas, Geissler, Claudia, Fernsebner, K., Geissler, C., Perobner, I., Peroebner, Iris, Jochum, Marianne, Lechner, Felix, Ruiz-Heinrich, L., Kolben, T., Capovilla, S.   +18 more
core   +1 more source

Maternal Wnt/β-catenin signaling coactivates transcription through NF-κB binding sites during Xenopus axis formation. [PDF]

, 2012
Maternal Wnt/β-Catenin signaling establishes a program of dorsal-specific gene expression required for axial patterning in Xenopus. We previously reported that a subset of dorsally expressed genes depends not only on Wnt/β-Catenin stimulation, but also ...
Rupp, Ralph A. W., Armstrong Neil J., Fagotto François, Christian Prothmann, Ralph A W Rupp, Prothmann, Christian, Neil J Armstrong, Rupp Ralph A. W., François Fagotto, Prothmann Christian, Fagotto, François, Armstrong, Neil J.   +11 more
core   +1 more source

The epithelial-mesenchymal transition induced by transcription factor LEF-1 is independent of β-catenin

Biochemistry and Biophysics Reports, 2018
Transcription factor lymphoid-enhancer–binding factor 1 (LEF-1) is a key molecule in the Wnt/β-catenin signaling pathway. Slug is one of the Wnt/β-catenin target genes and can induce epithelial–mesenchymal transition (EMT). Previously, we have shown that
Wakako Kobayashi, Masayuki Ozawa
doaj   +1 more source

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB

Cancer Cell International, 2020
Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu, Zhi-Xia Yue, Zhi-Gang Li, Rui-Dong Zhang, Hu-Yong Zheng, Xiao-Xi Zhao, Chao Gao   +6 more
doaj   +1 more source

β-catenin-IRP2-primed iron availability to mitochondrial metabolism is druggable for active β-catenin-mediated cancer

Journal of Translational Medicine, 2023
Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.
Yuting Wu, Shuhui Yang, Luyang Han, Kezhuo Shang, Baohui Zhang, Xiaochen Gai, Weiwei Deng, Fangming Liu, Hongbing Zhang   +8 more
doaj   +1 more source

Silencing mutated β-catenin inhibits cell proliferation and stimulates apoptosis in the adrenocortical cancer cell line H295R [PDF]

, 2013
Adrenocortical carcinoma (ACC) is a rare and highly aggressive endocrine neoplasm, with limited therapeutic options. Activating β-catenin somatic mutations are found in ACC and have been associated with a poor clinical outcome. In fact, activation of the
Lucile Lefèvre, Ragazzon, Bruno, Constanze Hantel (280561), Guillaud-Bataille, Marine, Bruno Ragazzon (140444), Launay, Pierre, Stéphane Bonnet (280565), Marthe Rizk-Rabin (280575), Marine Guillaud-Bataille (9131), Karine Perlemoine, Lefèvre, Lucile, Sébastien Gaujoux (280559), Tissier, Frédérique, Hantel, Constanze, Frédérique Tissier (140448), Lucile Lefèvre (280570), Rizk-Rabin, Marthe, Karine Perlemoine (280567), Bertherat, Jérôme, Stéphane Bonnet, Bonnet, Stéphane, Sébastien Gaujoux, Perlemoine, Karine, Jérôme Bertherat, Bruno Ragazzon, Beuschlein, Felix, Marthe Rizk-Rabin, Frédérique Tissier, Pierre Launay (280563), Jérôme Bertherat (140471), Felix Beuschlein, Marine Guillaud-Bataille, Constanze Hantel, Felix Beuschlein (158361), Gaujoux, Sébastien, Pierre Launay   +35 more
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Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway

BMC Veterinary Research, 2020
Background Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle.
Xinying Du, Wenqi He, Hongbin He, Hongmei Wang   +3 more
doaj   +1 more source

Amyloid precursor protein modulates β-catenin degradation

Journal of Neuroinflammation, 2007
Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
doaj   +1 more source

Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]

PLoS ONE, 2010
The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux, Janine L Coates, Nadia J Kershaw, Meredith J Layton, Antony W Burgess   +4 more
doaj   +1 more source