Results 11 to 20 of about 178,760 (268)
β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB
Cancer Cell International, 2020 Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu +6 more
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Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]
PLoS ONE, 2010 The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux +4 more
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Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway
BMC Veterinary Research, 2020 Background Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle.
Xinying Du +3 more
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Biochemistry and Biophysics Reports, 2018 Transcription factor lymphoid-enhancer–binding factor 1 (LEF-1) is a key molecule in the Wnt/β-catenin signaling pathway. Slug is one of the Wnt/β-catenin target genes and can induce epithelial–mesenchymal transition (EMT). Previously, we have shown that
Wakako Kobayashi, Masayuki Ozawa
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Journal of Translational Medicine, 2023 Background Although β-catenin signaling cascade is frequently altered in human cancers, targeting this pathway has not been approved for cancer treatment.
Yuting Wu +8 more
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Amyloid precursor protein modulates β-catenin degradation
Journal of Neuroinflammation, 2007 Background The amyloid precursor protein (APP) is genetically associated with Alzheimer's disease (AD). Elucidating the function of APP should help understand AD pathogenesis and provide insights into therapeutic designs against this devastating ...
Chen Yuzhi, Bodles Angela M
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, 2020 Additional file 8: Table S2. The qRT-PCR sequences of primers.
Feng, Yun +7 more
openaire +1 more source
Stem Cell Reports, 2016 Summary: Treatment with several Wnt/β-catenin signaling pathway regulators can change the cellular reprogramming efficiency; however, the dynamics and role of endogenous Wnt/β-catenin signaling in reprogramming remain largely unanswered. Here we identify
Mizuki Kimura +3 more
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Potential Canonical Wnt Pathway Activation in High-Grade Astrocytomas
The Scientific World Journal, 2012 Aberrant wnt pathway activation through cytoplasmic stabilization of β-catenin is crucial for the development of various human malignancies. In gliomagenesis, the role of canonical (i.e., β-catenin-dependent) signalling is largely unknown.
Rebecca Schüle +11 more
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Neoplasia: An International Journal for Oncology Research, 2013 β-Catenin is important in liver homeostasis as a part of Wnt signaling and adherens junctions (AJs), while its aberrant activation is observed in hepatocellular carcinoma (HCC).
Emily Diane Wickline +4 more
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