LEF-1 drives aberrant β-catenin nuclear localization in myeloid leukemia cells
Haematologica, 2019 Canonical Wnt/β-catenin signaling is frequently dysregulated in myeloid leukemias and is implicated in leukemogenesis. Nuclear-localized β-catenin is indicative of active Wnt signaling and is frequently observed in acute myeloid leukemia (AML) patients ...
Rhys G. Morgan +12 more
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Emerging Direct Targeting β-Catenin Agents
Molecules, 2022 Aberrant accumulation of β-catenin in the cell nucleus as a result of deregulation of the Wnt/β-catenin pathway is found in various types of cancer. Direct β-catenin targeting agents are being researched despite obstacles; however, specific β-catenin ...
Marianna Nalli +4 more
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Dissecting the impact of Frizzled receptors in Wnt/beta-catenin signaling of human mesenchymal stem cells [PDF]
, 2012 Wnt/beta-catenin signaling is of fundamental importance in the regulation of self-renewal, migration/invasion, and differentiation of human mesenchymal stem cells (hMSCs).
Ruiz-Heinrich, Lourdes +18 more
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Neoplasia: An International Journal for Oncology Research, 2016 β-Catenin is a major transducer of the Wnt signaling pathway, which is aberrantly expressed in colorectal and other cancers. Previously, we showed that β-catenin is downregulated by the 90K glycoprotein via ISGylation-dependent degradation.
So-Yeon Park +3 more
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Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis. [PDF]
PLoS ONE, 2016 β-catenin signaling is a major oncogenic pathway in hepatocellular carcinoma (HCC). Since β-catenin phosphorylation by glycogen synthase kinase 3β (GSK3β) and casein kinase 1ε (CK1ε) results in its degradation, mutations affecting these phosphorylation ...
Hirohisa Okabe +15 more
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Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. [PDF]
PLoS ONE, 2010 The APC tumour suppressor functions in several cellular processes including the regulation of β-catenin in Wnt signalling and in cell adhesion and migration.In this study, we establish that in epithelial cells N-terminally phosphorylated β-catenin ...
Maree C Faux +4 more
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β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB
Cancer Cell International, 2020 Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood.
Shu-Guang Liu +6 more
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Beta-catenin inhibits bovine parainfluenza virus type 3 replication via innate immunity pathway
BMC Veterinary Research, 2020 Background Bovine parainfluenza virus type 3 (BPIV3) is one of the important viral respiratory agents associated with the bovine respiratory disease complex (BRDC) in cattle.
Xinying Du +3 more
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A novel bidirectional positive feedback loop between Wnt/ -catenin and EGFR/ERK: role of context-specific signalling crosstalk in modulating epithelial tissue regeneration [PDF]
, 2014 By operating as both a subunit of the cadherin complex and a key component of Wnt signalling, β-catenin constitutes the lynchpin between cell:cell contact and transcriptional regulation of proliferation to co-ordinate epithelial tissue homeostasis and ...
Kirkwood, Lisa A. +2 more
core +4 more sources
Biochemistry and Biophysics Reports, 2018 Transcription factor lymphoid-enhancer–binding factor 1 (LEF-1) is a key molecule in the Wnt/β-catenin signaling pathway. Slug is one of the Wnt/β-catenin target genes and can induce epithelial–mesenchymal transition (EMT). Previously, we have shown that
Wakako Kobayashi, Masayuki Ozawa
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