Results 61 to 70 of about 886,342 (318)

Additional file 8: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S1. Clinicopathological characteristics of 102 HCC patients. (DOC 38 kb)
Deng, Ling, Sun, Jingyuan, Chen, Xiaohui, Liu, Li, Wu, Dehua   +4 more
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Hypoxia‐Induced Histone Lactylation Promotes Ferroptosis in Cardiomyocytes via the Wnt/β‐Catenin Pathway

Kaohsiung Journal of Medical Sciences
This study investigated the effects of histone lactylation on ferroptosis in hypoxia‐induced cardiomyocytes. A hypoxia model was established in AC16 cells treated with 2‐Deoxy‐D‐glucose (2‐DG, a glucose analogue), ferrostatin‐1 (Fer‐1, a selective ...
Xin‐Hua Zhu, Jing‐Wen Hou, Zhong‐Ying Lv, Ming‐Hui Sun, Xiao‐Yang Zhang, Lei Zhang, Mei Wang   +6 more
doaj   +1 more source

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease. [PDF]

PLoS ONE, 2011
Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-
Hoeke A Baarsma, Anita I R Spanjer, Gertruud Haitsma, Lilian H J M Engelbertink, Herman Meurs, Marnix R Jonker, Wim Timens, Dirkje S Postma, Huib A M Kerstjens, Reinoud Gosens   +9 more
doaj   +1 more source

MOESM1 of Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone

, 2019
Additional file 1: Table S1. Primers used for RT-qPCR.
Xuan, Fengjun, Yano, Fumiko, Mori, Daisuke, Chijimatsu, Ryota, Maenohara, Yuji, Nakamoto, Hideki, Mori, Yoshifumi, Makii, Yuma, Oichi, Takeshi, Taketo, Makoto, Hojo, Hironori, Ohba, Shinsuke, Chung, Ung-il, Tanaka, Sakae, Saito, Taku   +14 more
openaire   +1 more source

Table2_Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells.xlsx

, 2023
Introduction: Wnt/β-catenin signaling controls cell division and lineage specification during embryonic development, and is crucial for stem cells maintenance and gut tissue regeneration in adults.
Irina Elcheva (3844003), Vonn Walter (165501), Vladimir S. Spiegelman (10308404), Yuka Imamura Kawasawa (7254923), Vikash Singh (387413)   +4 more
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Elevated levels of Dickkopf-1 are associated with β-catenin accumulation and poor prognosis in patients with chondrosarcoma. [PDF]

PLoS ONE, 2014
BACKGROUND: Dickkopf-1 (DKK1) is an antagonist of Wnt/β-catenin signaling implicated in tumorigenesis. However, the biological role of DKK1 and β-catenin involved in chondrosarcoma has not been sufficiently investigated.
Changbao Chen, Hua Zhou, Xiaolin Zhang, Xinlong Ma, Zhongjun Liu, Xiaoguang Liu   +5 more
doaj   +1 more source

Additional file 9: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S2. Correlation between Nek2 expression and HCC clinicopathologic features. (DOCX 16 kb)
Deng, Ling, Sun, Jingyuan, Chen, Xiaohui, Liu, Li, Wu, Dehua   +4 more
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source