Results 81 to 90 of about 1,062,506 (300)

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Activation of WNT/β-catenin signaling in pulmonary fibroblasts by TGF-β₁ is increased in chronic obstructive pulmonary disease. [PDF]

PLoS ONE, 2011
Chronic obstructive pulmonary disease (COPD) is characterized by abnormal extracellular matrix (ECM) turnover. Recently, activation of the WNT/β-catenin pathway has been associated with abnormal ECM turnover in various chronic diseases. We determined WNT-
Hoeke A Baarsma, Anita I R Spanjer, Gertruud Haitsma, Lilian H J M Engelbertink, Herman Meurs, Marnix R Jonker, Wim Timens, Dirkje S Postma, Huib A M Kerstjens, Reinoud Gosens   +9 more
doaj   +1 more source

β-Catenin Controls the Electrophysiologic Properties of Skeletal Muscle Cells by Regulating the α2 Isoform of Na+/K+-ATPase

Frontiers in Neuroscience, 2019
β-Catenin is a key component of the canonical Wnt signaling pathway. It has been shown to have an important role in formation of the neuromuscular junction. Our previous studies showed that in the absence of β-catenin, the resting membrane potential (RMP)
Congying Zhao, Yonglin Yu, Yi Zhang, Jue Shen, Lihua Jiang, Guoxia Sheng, Weiqin Zhang, Lu Xu, Kewen Jiang, Kewen Jiang, Kewen Jiang, Shanshan Mao, Shanshan Mao, Peifang Jiang, Feng Gao   +14 more
doaj   +1 more source

MOESM1 of LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

, 2019
Additional file 1: Figure S1.Overview image of immunofluorescence staining (GFAP+) in SCI animal models at 1 and 2 weeks post-injury were shown.
Cui, Yi, Yin, Yanyun, Xiao, Zhifeng, Zhao, Yannan, Chen, Bing, Yang, Bin, Xu, Bai, Song, Hongwei, Zou, Yunlong, Ma, Xu, Dai, Jianwu   +10 more
openaire   +1 more source

BCL-3 and β-catenin signaling and tumor staging in colorectal cancer

Cellular and Molecular Biology, 2020
Colorectal cancer (CBC) is the third most common cancer in men and the second most common cancer in women in the world, as well as the second leading cause of death among the world's cancers. In this study, to identify the genes involved in the CRC clinical outcomes, the expression of B cell leukemia/lymphoma 3 (BCL-3) gene in patients with colorectal ...
Shanhong, Zhang, Changqing, Yin
openaire   +3 more sources

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer

Journal of Translational Medicine
Background Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approach.
Minting Chen, Baisen Chen, Qianyi He, Shilin Xiao, Baoting Li, Yun Ye, Hongjie Zhang, Hoi Leong Xavier Wong, Ying Ji, Tao Su, Hiu Yee Kwan   +10 more
doaj   +1 more source

Additional file 1: of β-Catenin nuclear localization positively feeds back on EGF/EGFR-attenuated AJAP1 expression in breast cancer

, 2019
Table S1. Clinicopathological parameters of breast cancer patients. (DOC 54 kb)
Xu, Cong, Liu, Fang, Xiang, Guomin, Cao, Lu, Wang, Shuling, Liu, Jing, Meng, Qingxiang, Xu, Danni, Lv, Shuhua, Jiao, Jiao, Niu, Yun   +10 more
openaire   +1 more source

EGFR and WNT/β-catenin signalling in airway homeostasis and repair [PDF]

, 2011
Lung cancers are a leading cause of death worldwide, and although there is some evidence that both Epidermal Growth Factor Receptor (EGFR) and Wnt/β-catenin signalling are involved in initiation and progression of this disease the molecular mechanisms
Lu, L.
core  

Table4_Global role of IGF2BP1 in controlling the expression of Wnt/β-catenin-regulated genes in colorectal cancer cells.xlsx

, 2023
Introduction: Wnt/β-catenin signaling controls cell division and lineage specification during embryonic development, and is crucial for stem cells maintenance and gut tissue regeneration in adults.
Irina Elcheva (3844003), Vonn Walter (165501), Vladimir S. Spiegelman (10308404), Yuka Imamura Kawasawa (7254923), Vikash Singh (387413)   +4 more
core   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source