Results 81 to 90 of about 262,733 (310)

Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2 [PDF]

, 2008
Background Homeodomain-interacting protein kinase-2 (HIPK2) plays an essential role in restraining tumor progression as it may regulate, by itself or within multiprotein complexes, many proteins (mainly transcription factors) involved in cell growth and ...
Rosa Puca, Lavinia Nardinocchi, Gabriella D'Orazi   +2 more
core   +2 more sources

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer

Journal of Translational Medicine
Background Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approach.
Minting Chen, Baisen Chen, Qianyi He, Shilin Xiao, Baoting Li, Yun Ye, Hongjie Zhang, Hoi Leong Xavier Wong, Ying Ji, Tao Su, Hiu Yee Kwan   +10 more
doaj   +1 more source

Additional file 2: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S1. Clinicopathological characteristics of studied patients and expression of miR-188-5p in STAD from TCGA Dataset. (DOCX 16 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source

Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development [PDF]

, 2012
Background: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell–cell communication ...
Huo, Randi, Li, Xiaokun, Li, Xue, Olson, Lorin E, Rosenfeld, Michael G, Sun, Ye, Teng, Ian   +6 more
core   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Astragalus Inhibits Epithelial-to-Mesenchymal Transition of Peritoneal Mesothelial Cells by Down-Regulating β-Catenin

Cellular Physiology and Biochemistry, 2018
Background/Aims: The epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a crucial event in the induction of peritoneal fibrosis (PF), in which canonical Wnt/β-catenin signaling participates.
Manshu Yu, Jun Shi, Meixiao Sheng, Kun Gao, Lu Zhang, Li Liu, Yilin Zhu   +6 more
doaj   +1 more source

MOESM1 of LncRNA Neat1 mediates miR-124-induced activation of Wnt/β-catenin signaling in spinal cord neural progenitor cells

, 2019
Additional file 1: Figure S1.Overview image of immunofluorescence staining (GFAP+) in SCI animal models at 1 and 2 weeks post-injury were shown.
Cui, Yi, Yin, Yanyun, Xiao, Zhifeng, Zhao, Yannan, Chen, Bing, Yang, Bin, Xu, Bai, Song, Hongwei, Zou, Yunlong, Ma, Xu, Dai, Jianwu   +10 more
openaire   +1 more source

LGR5 is associated with tumor aggressiveness in papillary thyroid cancer. [PDF]

, 2015
PurposeLeucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5) is a cancer stem cell marker and a down-stream target in Wnt/β-catenin signaling. In human papillary thyroid cancer (PTC), over activation of Wnt/β-catenin has been associated with
Diehl, Anna Mae, Henderson, Brittany Bohinc, Jiang, Xiaoyin, Michelotti, Gregory, Sosa, Julie Ann   +4 more
core   +3 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source