Results 81 to 90 of about 886,342 (318)

Supplementary Figure S1. Densitometric analysis of total β-catenin, active β-catenin, AurKA, p-AktSer473, p-GSK3βSer9 and p-Mcl-1Ser159 expression. from Loss of PKCδ Induces Prostate Cancer Resistance to Paclitaxel through Activation of Wnt/β-Catenin Pathway and Mcl-1 Accumulation

, 2023
<p>PKCÎ'-silenced PC3 (a) and LNCaP (b) cells were treated with DMSO or paclitaxel 2.5 µM 48 hours. Histograms show densitometric and statistical analysis of indicated proteins from panels (c) and (d) of the Figure 3. Data are presented as mean{plus minus}S.E.M.
Carmen Sáez, Miguel A. Japón, Francisco Romero, Begoña Pérez-Valderrama, Rafael Medina, Jessica Gasca, Carolina Castilla, M. Luz Flores   +7 more
openaire   +1 more source

Dynamics of Wnt/β-catenin signalling during cerebellum development [PDF]

, 2012
Medulloblastomas are tumours of cerebellar origin and are thought to arise from the malignant transformation of progenitor cells in the developing cerebellum. A number of developmental signalling pathways are required for the precise cell specification,
Selvadurai, Hayden John
core  

β-catenin-dependent H3K79 methylation and MLLT10/AF10, DOT1L recruitment to human AXIN2 gene.

, 2017
Cell lysates from Ls174T CRCs were immunoprecipitated with antibodies against endogenous MLLT10/AF10 (A) and DOT1L (B) complexes and analyzed by Western blotting with the indicated antibodies.
Robert G. J. Vries (237198), Shabaz Mohammed (237215), Albert J. R. Heck (9680), Sylvia F. Boj (237185), Nadia Taouatas (237192), Pantelis Hatzis (236332), Harry Begthel (237205), Hans Clevers (211819), Hans Teunissen (226813), Tokameh Mahmoudi (195250), Vivian S. W. Li (211770), Jeroen Korving (237210)   +11 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Additional file 7: of RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

, 2019
Table S3. Relationship between RUNX1 mRNA expression and the clinicpathological features of CRC patients. (DOCX 14 kb)
Li, Qingyuan, Lai, Qiuhua, He, Chengcheng, Fang, Yuxin, Yan, Qun, Zhang, Yue, Wang, Xinke, Gu, Chuncai, Wang, Yiqing, Ye, Liangying, Han, Lu, Lin, Xin, Chen, Junsheng, Cai, Jianqun, Li, Aimin, Liu, Side   +15 more
openaire   +1 more source

Natural Biomaterials for Osteochondral Repair: From Source to Strategy

Advanced Healthcare Materials, EarlyView.
Biological origin‐guided overview of natural biomaterials and therapeutic strategies for osteochondral tissue engineering. The circular diagram categorizes representative materials and strategies into plant/algae‐derived, microbial‐derived, animal‐derived, and human‐derived sources, centered on an osteochondral defect repair model.
Hengyu Liu, Hanyang Zhang, Wenbo Yang, Hao Chen, Jincheng Wang, Fei Chang   +5 more
wiley   +1 more source

Additional file 6: of RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

, 2019
Table S2. Chip primer sequenced used for quantitative real-time PCR. (DOC 29 kb)
Li, Qingyuan, Lai, Qiuhua, He, Chengcheng, Fang, Yuxin, Yan, Qun, Zhang, Yue, Wang, Xinke, Gu, Chuncai, Wang, Yiqing, Ye, Liangying, Han, Lu, Lin, Xin, Chen, Junsheng, Cai, Jianqun, Li, Aimin, Liu, Side   +15 more
openaire   +1 more source

BCL-3 and β-catenin signaling and tumor staging in colorectal cancer

Cellular and Molecular Biology, 2020
Colorectal cancer (CBC) is the third most common cancer in men and the second most common cancer in women in the world, as well as the second leading cause of death among the world's cancers. In this study, to identify the genes involved in the CRC clinical outcomes, the expression of B cell leukemia/lymphoma 3 (BCL-3) gene in patients with colorectal ...
Shanhong, Zhang, Changqing, Yin
openaire   +3 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

15,16-Dihydrotanshinone I, a novel β-catenin-targeting inhibitor that inhibits its nuclear translocation and reduces downstream CD36 expression in cancer

Journal of Translational Medicine
Background Wnt/β-catenin signaling drives many cancers; however, current inhibition strategies have limitations. Direct β-catenin inhibitors that block nuclear translocation represent an alternative therapeutic approach.
Minting Chen, Baisen Chen, Qianyi He, Shilin Xiao, Baoting Li, Yun Ye, Hongjie Zhang, Hoi Leong Xavier Wong, Ying Ji, Tao Su, Hiu Yee Kwan   +10 more
doaj   +1 more source