Results 101 to 110 of about 262,733 (310)

Melanoma Development and Progression Are Associated with Rad6 Upregulation and β-Catenin Relocation to the Cell Membrane

Journal of Skin Cancer, 2014
We have previously demonstrated that Rad6 and β-catenin enhance each other's expression through a positive feedback loop to promote breast cancer development/progression. While β-catenin has been implicated in melanoma pathogenesis, Rad6 function has not
Karli Rosner, Darius R. Mehregan, Evangelia Kirou, Judith Abrams, Seongho Kim, Michelle Campbell, Jillian Frieder, Kelsey Lawrence, Brittany Haynes, Malathy P. V. Shekhar   +9 more
doaj   +1 more source

Additional file 9: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S2. Correlation between Nek2 expression and HCC clinicopathologic features. (DOCX 16 kb)
Deng, Ling, Jingyuan Sun, Xiaohui Chen, Liu, Li, Dehua Wu   +4 more
openaire   +1 more source

Evidence that fold-change, and not absolute level, of β-catenin dictates Wnt signaling [PDF]

, 2009
In response to Wnt stimulation, β-catenin accumulates and activates target genes. Using modeling and experimental analysis, we found that the level of β-catenin is sensitive to perturbations in the pathway, such that cellular variation would be expected ...
Goentoro, Lea, Kirschner, Marc W.
core   +2 more sources

Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy

Advanced Healthcare Materials, EarlyView.
This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su, Zihao He, Qianqian Chen, Long Chen, Caiyi Wei, Zijin Zhou, Jianhao Lin, Hui Li, Dan Xing   +8 more
wiley   +1 more source

Additional file 1: of β-Catenin nuclear localization positively feeds back on EGF/EGFR-attenuated AJAP1 expression in breast cancer

, 2019
Table S1. Clinicopathological parameters of breast cancer patients. (DOC 54 kb)
Xu, Cong, Liu, Fang, Xiang, Guomin, Cao, Lu, Wang, Shuling, Liu, Jing, Meng, Qingxiang, Xu, Danni, Lv, Shuhua, Jiao, Jiao, Niu, Yun   +10 more
openaire   +1 more source

Wnt/β-catenin pathway as a potential prognostic and predictive marker in patients with advanced ovarian cancer [PDF]

, 2014
BACKGROUND: β-catenin is the key protein in the WNT signalling pathway and it forms adherent junctions together with E-cadherin. In ovarian carcinoma, abnormal expression of β-catenin, E-cadherin and WNT-1 was observed, but their prognostic and ...
Aleksandra Stanczak, Cezary Szczylik, Lubomir Bodnar, Maciej Wieczorek, Marta Smoter, Marzena Cichowicz, Monika Lamparska-Przybysz, Szczepan Cierniak, Wojciech Kozlowski   +8 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

MicroRNA roles in beta-catenin pathway [PDF]

, 2010
β-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Kai Huang, Jun-Xia Zhang, Lei Han, Yong-Ping You, Tao Jiang, Pei-Yu Pu, Chun-Sheng Kang   +6 more
core   +2 more sources

Additional file 10: of Nek2 augments sorafenib resistance by regulating the ubiquitination and localization of β-catenin in hepatocellular carcinoma

, 2019
Table S3. Univariate and multivariate analyses of OS in 102 HCC patients by Cox regression analysis. (DOCX 14 kb)
Deng, Ling, Jingyuan Sun, Xiaohui Chen, Liu, Li, Dehua Wu   +4 more
openaire   +1 more source

Bioelectrical Interfaces Beyond Excitable Cells: Cancer, Aging, and Gene Expression Modulation

Advanced Materials Interfaces, EarlyView.
ABSTRACT The investigation of biological conductivity has evolved from its classical foundation based on ionic fluxes underpinning cardiac and neuronal excitability to a multifaceted regulator of cellular physiology. Traditional approaches for probing electrical events in living matter focused largely on action potentials recording.
Paolo Cadinu, Matthew K. Burgess, Catarina Franco Jones, Marzia Iarossi, Manuel Schröter, Nako Nakatsuka, Mustafa B. A. Djamgoz, Gil Gonçalves, Sidahmed Abayzeed, Paola Sanjuán‐Alberte, Paula M. Mendes, Frankie J. Rawson, Malavika Nair, Michael Levin, Rosalia Moreddu   +14 more
wiley   +1 more source