Results 121 to 130 of about 886,342 (318)

Additional file 2: of The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

, 2018
Table S1. Primary antibodies for western blot. Table S2. Primers for real-time PCR. Table S3. Association between clinicopathological features and NEAT1 expression. Table S4. Univariate Cox proportional hazards model for overall survival (OS) and disease-free survival (DFS). Table S5. Multivariate Cox proportional hazards model for OS and DFS.
Zhang, Meng, Weng, Weiwei, Zhang, Qiongyan, Wu, Yong, Ni, Shujuan, Tan, Cong, Xu, Midie, Sun, Hui, Liu, Chenchen, Wei, Ping, Du, Xiang   +10 more
openaire   +1 more source

EGFR and WNT/β-catenin signalling in airway homeostasis and repair

, 2011
Lung cancers are a leading cause of death worldwide, and although there is some evidence that both Epidermal Growth Factor Receptor (EGFR) and Wnt/β-catenin signalling are involved in initiation and progression of this disease the molecular mechanisms
Lu, L.
core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

PLoS ONE, 2017
Abnormal activation of the Wnt/β-catenin signaling is implicated in the osteoarthritis (OA) pathology. We searched for a pre-approved drug that suppresses abnormally activated Wnt/β-catenin signaling and has a potency to reduce joint pathology in OA.
Kentaro Miyamoto, Bisei Ohkawara, Mikako Ito, Akio Masuda, Akihiro Hirakawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Naoki Ishiguro, Kinji Ohno   +9 more
doaj   +1 more source

MOESM1 of A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells

, 2019
Additional file 1. Minimum standards of reporting checklist.
Li, Wa, Yang, Chun-juan, Wang, Li-qian, Wu, Juan, Dai, Cong, Yuan, Yue-mei, Li, George, Yao, Mei-cun   +7 more
openaire   +1 more source

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

The role of beta-catenin in the development of fetal ovary and female germ cells

, 2010
Ovarian development in mammals is considered as a default process, arising only in the absence of Sry, a testis-determining gene. However, current evidence has suggested the presence of an active pathway in fetal ovary.
Liu, Chia-Feng
core  

Reduced β-catenin expression affects patterning of bone primordia, but not bone maturation [PDF]

, 2017
Wnt/β-catenin signaling is involved in patterning of bone primordia, but also plays an important role in the differentiation of chondrocytes and osteoblasts. During these processes the level of β-catenin must be tightly regulated.
Uyen Huynh-Do, Rudloff, Stefan, Huynh-Do, Uyen, Stefan Rudloff, Pflug, Tobias, Tobias Pflug   +5 more
core   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Additional file 2: of Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

, 2019
Table S1. Clinicopathological characteristics of studied patients and expression of miR-188-5p in STAD from TCGA Dataset. (DOCX 16 kb)
Li, Yun, Yan, Xiaoli, Shi, Jiajian, He, Yun, Xu, Jie, Lin, Liying, Chen, Wannan, Lin, Xinjian, Lin, Xu   +8 more
openaire   +1 more source