Results 121 to 130 of about 1,062,506 (300)

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Frontiers in Pharmacology, 2018
The β-catenin and MDM2 oncoproteins are overexpressed and constitutively activated in human pancreatic cancer and contribute to its initiation, progression, and metastasis.
Jiang-Jiang Qin, Wei Wang, Wei Wang, Xin Li, Hemantkumar Deokar, John K. Buolamwini, Ruiwen Zhang, Ruiwen Zhang   +7 more
doaj   +1 more source

Additional file 2: of The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

, 2018
Table S1. Primary antibodies for western blot. Table S2. Primers for real-time PCR. Table S3. Association between clinicopathological features and NEAT1 expression. Table S4. Univariate Cox proportional hazards model for overall survival (OS) and disease-free survival (DFS). Table S5. Multivariate Cox proportional hazards model for OS and DFS.
Zhang, Meng, Weng, Weiwei, Zhang, Qiongyan, Wu, Yong, Ni, Shujuan, Tan, Cong, Xu, Midie, Sun, Hui, Liu, Chenchen, Wei, Ping, Du, Xiang   +10 more
openaire   +1 more source

β-catenin-dependent H3K79 methylation and MLLT10/AF10, DOT1L recruitment to human AXIN2 gene.

, 2017
Cell lysates from Ls174T CRCs were immunoprecipitated with antibodies against endogenous MLLT10/AF10 (A) and DOT1L (B) complexes and analyzed by Western blotting with the indicated antibodies.
Robert G. J. Vries (237198), Shabaz Mohammed (237215), Albert J. R. Heck (9680), Sylvia F. Boj (237185), Nadia Taouatas (237192), Pantelis Hatzis (236332), Harry Begthel (237205), Hans Clevers (211819), Hans Teunissen (226813), Tokameh Mahmoudi (195250), Vivian S. W. Li (211770), Jeroen Korving (237210)   +11 more
core   +1 more source

DataSheet1_CXC Chemokine Receptor 2 Accelerates Tubular Cell Senescence and Renal Fibrosis via β-Catenin-Induced Mitochondrial Dysfunction.docx

, 2022
Renal fibrosis is a common feature of various chronic kidney diseases (CKD). However, its underlying mechanism has not been totally clarified. C-X-C motif chemokine receptor (CXCR) family plays a role in renal fibrosis, however, detailed mechanisms have ...
Jingyan Wei (1716046), Lili Zhou (265076), Weiwei Shen (750987), Yunfang Zhang (585611), Mingsheng Zhu (286113), Jinhua Miao (12177029), Jiemei Li (9116858), Jiewu Huang (11899382), Ping Meng (250328), Huiyun Ye (12491425), Xian Ling (12491422), Hongxin Niu (12491428), Shan Zhou (112166)   +12 more
core   +1 more source

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

Oncogenic β-catenin mutations evade pH-regulated degradation

Molecular & Cellular Oncology, 2019
β-catenin has roles in cell-cell adhesion and Wnt signaling. We recently showed that β-catenin protein abundance is decreased at higher intracellular pH (pHi), mediated by pH-sensitive interaction with the beta-transducin repeat containing E3 ubiquitin ...
Bree K. Grillo-Hill, Katharine A. White
doaj   +1 more source

MOESM2 of A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells

, 2019
Additional file 2. Additional Figures and Table.
Li, Wa, Yang, Chun-juan, Wang, Li-qian, Wu, Juan, Dai, Cong, Yuan, Yue-mei, Li, George, Yao, Mei-cun   +7 more
openaire   +1 more source

RETRACTED ARTICLE: MicroRNA-188-5p Promotes Epithelial–Mesenchymal Transition by Targeting ID4 Through Wnt/β-catenin Signaling in Retinoblastoma

, 2019
This paper has been retracted. Yang M, Li Y, Wei W. Onco Targets Ther. 2019;12:10251-10262. We, the Editors and Publisher of OncoTargets and Therapy, have retracted the following article. Concerns were raised about the integrity of the data in the article after it was found images from Figure 3 had been duplicated with those from other unrelated ...
Yang,Ming, Li,Yang, Wei,Wenbin
openaire   +2 more sources

Sustainable Fabrication of Tailored Bone Substitutes: From High‐Throughput Scaffold Manufacturing, Scaled‐Up HMSC Expansion to Dynamic Cultivation in a Perfusion Bioreactor

Advanced Science, EarlyView.
ABSTRACT The demand for off‐the‐shelf biocompatible bone substitutes has driven the development of numerous independent in vitro technologies to generate products resembling physiological tissues. Due to technical challenges and overly simplified cultivation approaches/niches, the end‐products are often uniformly shaped and inferior to native bone ...
Franziska Braun, Anna Paříková, Sandra Rother, Martin Kantor, Salman Muhammad Ilyas, Ricardo Bernhardt, Pavel Ndjawa Yomi, Jaromír Havlica, Revathi Appali, Benjamin Kruppke, Poh Soo Lee   +10 more
wiley   +1 more source

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin

Natural Products and Bioprospecting
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed,
Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan Li   +8 more
doaj   +1 more source