Results 141 to 150 of about 886,342 (318)

Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis

Cell Communication and Signaling
Background & aims The Wnt/β-catenin signaling pathway is critical for liver homeostasis. We have previously shown that hepatocyte β-catenin plays a pleiotropic role in cholestatic injury.
Matthew Carson, Jamie Fornsaglio, Ridgeway Case IV, Rithwik Aggarwal, Vik Meadows, Chang Kyung Kim, Laura Molina, Pamela Cornuet, Jia-Jun Liu, Silvia Liu, Kari Nejak-Bowen   +10 more
doaj   +1 more source

Additional file 1: of The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

, 2018
Supplemental materials and methods. (DOCX 20 kb)
Zhang, Meng, Weng, Weiwei, Zhang, Qiongyan, Wu, Yong, Ni, Shujuan, Tan, Cong, Xu, Midie, Sun, Hui, Liu, Chenchen, Wei, Ping, Du, Xiang   +10 more
openaire   +1 more source

Tumor‐Intrinsic ARHGEF3 Enhances Antitumor Immunity by Promoting T‐Cell Infiltration and Limiting Myeloid Cell‐Mediated Immunosuppression

Advanced Science, EarlyView.
ARHGEF3 is broadly downregulated across human cancers and correlates with patient prognosis. Tumor‐intrinsic ARHGEF3 activates the RHOA–ROCK–PTEN cascade to inhibit AKT signaling, thereby promoting chemokine‐driven T‐cell infiltration and relieving lipid‐mediated myeloid immunosuppression.
Yue Li, Lan Wang, Zihao Zhang, Chunmei Qian, Ning Li, Wei Huang, Qian Ba, Xiaojian Liu, Mayu Sun   +8 more
wiley   +1 more source

An anterior program of gene expression is acutely up-regulated after β-catenin-1 inhibition in planarians.

, 2019
(A) Experimental scheme for RNA sequencing. Schmidtea mediterranea adults were fed once with control or β-catenin-1 dsRNA. Tails were collected in trizol 1, 2, 4, and 6 days after feeding for RNA sequencing. Red box indicates tissue collected.
Daniel E. Wagner (7517981), Jared H. Owen (7517975), Aneesha G. Tewari (7517972), Christian P. Petersen (7517978), Peter W. Reddien (7517984)   +4 more
core   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Additional file 1: of Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade

, 2018
Supplementary Methods. (DOCX 19 kb)
Cai, Cheng-fu, Ye, Guo-dong, Shen, Dong-yan, Zhang, Wei, Chen, Mao-li, Chen, Xin-xin, Han, Da-xiong, Mi, Yan-jun, Luo, Qi-cong, Cai, Wang-yu, Yang, Shu-yu   +10 more
openaire   +1 more source

A posterior program of gene expression is down-regulated after β-catenin-1 inhibition in acoels.

, 2019
(A) Experimental scheme for RNA sequencing. Hofstenia miamia were injected once a day for three consecutive days with control or β-catenin-1 dsRNA. Tails were collected in trizol at 3, 7, and 14 days after the first injection for RNA sequencing.
Daniel E. Wagner (7517981), Jared H. Owen (7517975), Aneesha G. Tewari (7517972), Christian P. Petersen (7517978), Peter W. Reddien (7517984)   +4 more
core   +1 more source

Hyperlipidemia Aggravates Alveolar Bone Loss via Periodontal Ligament Stem Cell Ferroptosis Through GSK3β Dependent Ubiquitin‐Mediated NRF2 Degradation

Advanced Science, EarlyView.
Lipid metabolic stress triggers ferroptosis in PDLSCs through the GSK3β/NRF2 pathway, thereby aggravating periodontal bone loss. Upregulated GSK3β promotes NRF2 ubiquitination and proteasomal degradation via β‐TrCP, suppressing NRF2 nuclear translocation and antioxidant target expression.
Yuxiao Zhang, Xiangyao Wang, Yaxin Wu, Liping Liu, Gaoshaer Nuerlan, Ahsawle Ozathaley, Xiaorui Zhang, Jinping Wang, Bowen Yang, Jing Mao, Yan Liu, Shiqiang Gong   +11 more
wiley   +1 more source

Additional file 2: Figure. S1. of Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway

, 2017
Sequencing results of the pLenti6.3-Core, pLenti6.3-NS4B and pLenti6.3-mkate2 (partial). (DOCX 274 kb)
Jiang, Xiao-Hua, Xie, Yu-Tao, Cai, Ya-Ping, Ren, Jing, Ma, Tao   +4 more
openaire   +1 more source

A morphologic and immunohistochemical analysis of gastric adenocarcinoma with regard to the presence of E-cadherin and localisation of β-catenin staining

, 2014
Includes abstract.
Roberts, Riyaadh
core