Results 141 to 150 of about 1,062,506 (300)

Additional file 2: Figure. S1. of Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway

, 2017
Sequencing results of the pLenti6.3-Core, pLenti6.3-NS4B and pLenti6.3-mkate2 (partial). (DOCX 274 kb)
Jiang, Xiao-Hua, Xie, Yu-Tao, Cai, Ya-Ping, Ren, Jing, Ma, Tao   +4 more
openaire   +1 more source

K-Ras and β-catenin mutations cooperate with Fgfr3 mutations in mice to promote tumorigenesis in the skin and lung, but not in the bladder [PDF]

, 2011
The human fibroblast growth factor receptor 3 (FGFR3) gene is frequently mutated in superficial urothelial cell carcinoma (UCC). To test the functional significance of FGFR3 activating mutations as a ‘driver’ of UCC, we targeted the expression of mutated
Taketo, M.M., Leung, H.Y., Hing Y. Leung, Wu, X.-R., Iwata, T., Mona Foth, Morris, C.-A., Owen J. Sansom, Lukram Babloo Singh, Tomoko Iwata, Imran Ahmad, Carol-Ann Morris, Makoto Mark Taketo, Singh, L.B., Foth, M., Sansom, O.J., Xue-Ru Wu, Ahmad, I.   +17 more
core   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Additional file 1: of Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

, 2019
Table S1: Clinicopathological characteristics and tumor expression of NUSAP1 in cervical cancer patients. (DOCX 17 kb)
Li, Han, Zhang, Weijing, Yan, Ming, Qiu, Jiaqi, Chen, Jueming, Sun, Xiaoying, Chen, Xiangfu, Song, Libing, Zhang, Yanna   +8 more
openaire   +1 more source

SOX5 Orchestrates Malignant Evolution via Promoter‐Centric Chromatin Remodeling in MYC‐Driven B‐Cell Lymphoma

Advanced Science, EarlyView.
In MYC‐enforced B‐cell lymphoma, SOX5 occupies promoter‐proximal regulatory regions and is associated with reduced chromatin accessibility at the PCNP locus. PCNP repression promotes proliferative remodeling by limiting apoptosis and cell‐cycle restraint.
Yiyou Mao, Zhenyuan Jia, Xiao‐Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng   +6 more
wiley   +1 more source

Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells

Iranian Journal of Medical Sciences, 2017
Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway.
Marie Saghaeian Jazi, Seyed Mahmoud Arab Najafi   +1 more
doaj  

Additional file 1: of Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade

, 2018
Supplementary Methods. (DOCX 19 kb)
Cai, Cheng-fu, Ye, Guo-dong, Shen, Dong-yan, Zhang, Wei, Chen, Mao-li, Chen, Xin-xin, Han, Da-xiong, Mi, Yan-jun, Luo, Qi-cong, Cai, Wang-yu, Yang, Shu-yu   +10 more
openaire   +1 more source

Additional file 1: Figure S1. of Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

, 2017
Effect of glutamine depletion on stem-like SP fraction in pancreatic cancer AsPC-1 cells. Figure S2: Effect of glutaminase on percentage of SP cells in A549 cells. Figure S3: Effect of glutamine deprivation on neurosphere formation capacity of glioblastoma stem cells. Figure S4.
Liao, Jianwei, Liu, Pan-Pan, Hou, Guoxin, Shao, Jiajia, Yang, Jing, Liu, Kaiyan, Lu, Wenhua, Wen, Shijun, Hu, Yumin, Huang, Peng   +9 more
openaire   +1 more source

AI‐Assisted Engineering of Glycyrrhizic Acid/Simvastatin Nanocrystals for Multifunctional Treatment of Bacterial Osteomyelitis

Advanced Science, EarlyView.
Through AI‐assisted screening from FDA‐approved API to overcome the limitations of bacterial osteomyelitis treatment, glycyrrhizic acid and simvastatin are identified as a multifunctional combination capable of self‐assembling into mechanism‐targeting nanocrystals that effectively neutralize reactive oxygen species, suppress M1 macrophage polarization,
Yu Han, Yao Zhao, Chengbo Yang, Miao Niu, Jun Dai, Quanxin Ning, Kai Xiao, Jinzheng Liang, Wensheng Zhang, Liang Wang, Dan Shao, Dongsong Li   +11 more
wiley   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source