Results 141 to 150 of about 262,733 (310)

Beta-catenin Forms Protein Aggregation at High Concentrations in HEK293TCells

Iranian Journal of Medical Sciences, 2017
Background: The canonical Wnt signal transduction (or the Wnt/β-catenin pathway) plays a crucial role in the development of animals and in carcinogenesis. Beta-catenin is the central component of this signaling pathway.
Marie Saghaeian Jazi, Seyed Mahmoud Arab Najafi   +1 more
doaj  

Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis

Cell Communication and Signaling
Background & aims The Wnt/β-catenin signaling pathway is critical for liver homeostasis. We have previously shown that hepatocyte β-catenin plays a pleiotropic role in cholestatic injury.
Matthew Carson, Jamie Fornsaglio, Ridgeway Case IV, Rithwik Aggarwal, Vik Meadows, Chang Kyung Kim, Laura Molina, Pamela Cornuet, Jia-Jun Liu, Silvia Liu, Kari Nejak-Bowen   +10 more
doaj   +1 more source

Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.

PLoS ONE, 2013
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithelial cell-cell adhesion. Reduction and loss of catenin expression degrades E-cadherin-mediated carcinoma cell-cell adhesion and causes carcinomas to ...
Kazunobu Sasaya, Haruka Sudo, Genta Maeda, Shuichi Kawashiri, Kazushi Imai   +4 more
doaj   +1 more source

Additional file 1: of Chibby suppresses aerobic glycolysis and proliferation of nasopharyngeal carcinoma via the Wnt/β-catenin-Lin28/let7-PDK1 cascade

, 2018
Supplementary Methods. (DOCX 19 kb)
Cai, Cheng-fu, Ye, Guo-dong, Shen, Dong-yan, Zhang, Wei, Chen, Mao-li, Chen, Xin-xin, Han, Da-xiong, Mi, Yan-jun, Luo, Qi-cong, Cai, Wang-yu, Yang, Shu-yu   +10 more
openaire   +1 more source

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy. [PDF]

, 2019
The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases.
Chen, Lin, Liu, Dan, Ma, Shuang-Cheng, Vaziri, Nosratola D, Zhao, Hui, Zhao, Ying-Yong   +5 more
core  

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

Additional file 1: of Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway

, 2018
Binding Mode Prediction of Azoramide and figure legend of additional file 2. (DOCX 31 kb)
Ruan, Banjun, Zhu, Zheng, Yan, Zhao, Yang, Wei, Zhai, Dongsheng, Wang, Li, Ye, Zichen, Lu, Huanyu, Xiang, An, Liang, Jingwei, Jiang, Yinghao, Xu, Chengming, Wang, Zhenyu, Wei, Ming, Lei, Xiaoying, Cao, Xiaorui, Lu, Zifan   +16 more
openaire   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Additional file 1: Table S1. of PRC1 contributes to tumorigenesis of lung adenocarcinoma in association with the Wnt/β-catenin signaling pathway

, 2017
The clinicopathologic characteristics of the patients with 30 NSCLC participants employed for qRT-PCR assay of PRC1 mRNA expression. Table S2. The primers used in qPCR analysis. Table S3. The relative information on the antibodies in our study. (DOCX 26Â kb)
Zhan, Ping, Zhang, Bin, Xi, Guang-Min, Wu, Ying, Liu, Hong-Bing, Liu, Ya-Fang, Wu-Jian Xu, Zhu, Qing-Qing, Cai, Feng, Zhou, Ze-Jun, Miu, Ying-Ying, Wang, Xiao-Xia, Jin, Jia-Jia, Li, Qian, Qian, Li-Ping, Tang-Feng Lv, Song, Yong   +16 more
openaire   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source