Results 161 to 170 of about 262,733 (310)

Activation of β-catenin signalling leads to temporomandibular joint defects [PDF]

European Cells & Materials, 2014
Despite extensive research in knee and hip osteoarthritis (OA), the underlying mechanism of temporomandibular joint (TMJ) disorder remains largely unknown. The purpose of this study was to determine whether the constitutive activation of β-catenin in the
M Wang, S Li, W Xie, J Shen, H-J Im, JD Holz, M Wang, TGH Diekwisch, D Chen   +8 more
doaj  

Mechanical factors influence β-catenin localization and barrier properties

ISSN:1757 ...
Wu, Xi, Cesarovic, Nikola; id_orcid0000-0001-6744-2928, Falk, Volkmar; id_orcid0000-0002-7911-8620, Mazza, Edoardo; id_orcid0000-0001-9427-4157, Giampietro, Costanza; id_orcid0000-0001-5229-3835   +4 more
openaire   +1 more source

MOESM1 of Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelialâ mesenchymal transition through Wnt/β-catenin pathway

, 2019
Additional file 1: Table S1. Characteristics of the 4 kinds of human gastric cancer cell lines used in the study.
Yao, Han-Hui, Zhao, Ya-Jun, He, Yi-Fu, Huang, Da-Bing, Wang, Wei   +4 more
openaire   +1 more source

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Additional file 2: of Long non-coding RNA LUCAT1/miR-5582-3p/TCF7L2 axis regulates breast cancer stemness via Wnt/β-catenin pathway

, 2019
Table S2. Antibodies used for IHC and WB. (DOCX 16 kb)
Zheng, Ang, Song, Xinyue, Zhang, Lin, Zhao, Lin, Mao, Xiaoyun, Wei, Minjie, Jin, Feng   +6 more
openaire   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, EarlyView.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

Additional file 2: Figure. S1. of Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway

, 2017
Sequencing results of the pLenti6.3-Core, pLenti6.3-NS4B and pLenti6.3-mkate2 (partial). (DOCX 274Â kb)
Jiang, Xiao-Hua, Xie, Yu-Tao, Cai, Ya-Ping, Ren, Jing, Ma, Tao   +4 more
openaire   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Transport of Golgi-localized β-catenin p-S47 by KIF11 or KIFC3 induces primary ciliogenesis

Molecules and Cells
: Primary cilium is an important hub for cell signaling and dysregulation of primary cilia assembly and disassembly is associated with the development of cancer and chemotherapeutic drug resistance, as well as the genetic disorders collectively known as ...
Na Yeong Lee, Mi-Lang Kyun, Ji Eun Yu, Sun-Ok Kim, Key-Hwan Lim, Kyung Ho Lee   +5 more
doaj   +1 more source

Additional file 1: of 6-Gingerol stabilized the p-VEGFR2/VE-cadherin/β-catenin/actin complex promotes microvessel normalization and suppresses tumor progression

, 2019
Figure S1. The calculation process of fractal dimension. Figure S2. Pathway analysis revealed that 6G influenced VEGFa/VEGFR2 pathways. Figure S3. Positive pull-down assay of 6G with VEGFR1 and VEGFR2. Figure S4. Flow cytometry analysis of 6G treated and untreated cells.
Zhong, Weilong, Yang, Wendong, Qin, Yuan, Gu, Wenguang, Xue, Yinyin, Tang, Yuanhao, Xu, Hengwei, Wang, Hongzhi, Zhang, Chao, Wang, Changhua, Sun, Bo, Liu, Yanrong, Liu, Huijuan, Zhou, Honggang, Chen, Shuang, Sun, Tao, Yang, Cheng   +16 more
openaire   +1 more source