Results 161 to 170 of about 886,342 (318)

Light‐Switched Mesenchymal Stem Cells for In Situ Exosome Amplification in Craniofacial Bone Defect Reconstruction

Advanced Science, EarlyView.
Light‐switchable MSCs (MSC‐UCNPs) were constructed by intracellular incorporation of UCNPs. Upon 980 nm irradiation, UCNPs emitted localized ultraviolet light (365 nm), activating the ROS/HEXB/LAMP1 signaling pathway to suppress lysosome–multivesicular body fusion and thereby enhance exosome biogenesis. Embedded within an injectable hydrogel, MSC‐UCNPs
Tingting Wu, Yajing Liu, Shuman Wang, Xiaoming Bai, Luyun Zhang, Yuwei Liu, Zhiwen Fu, Chen Shi   +7 more
wiley   +1 more source

Additional file 1: of Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

, 2019
Table S1: Clinicopathological characteristics and tumor expression of NUSAP1 in cervical cancer patients. (DOCX 17 kb)
Li, Han, Zhang, Weijing, Yan, Ming, Qiu, Jiaqi, Chen, Jueming, Sun, Xiaoying, Chen, Xiangfu, Song, Libing, Zhang, Yanna   +8 more
openaire   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

Mechanical factors influence β-catenin localization and barrier properties

ISSN:1757 ...
Wu, Xi, Cesarovic, Nikola; id_orcid0000-0001-6744-2928, Falk, Volkmar; id_orcid0000-0002-7911-8620, Mazza, Edoardo; id_orcid0000-0001-9427-4157, Giampietro, Costanza; id_orcid0000-0001-5229-3835   +4 more
openaire   +1 more source

Additional file 1: Figure S1. of Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

, 2017
Effect of glutamine depletion on stem-like SP fraction in pancreatic cancer AsPC-1 cells. Figure S2: Effect of glutaminase on percentage of SP cells in A549 cells. Figure S3: Effect of glutamine deprivation on neurosphere formation capacity of glioblastoma stem cells. Figure S4.
Liao, Jianwei, Liu, Pan-Pan, Hou, Guoxin, Shao, Jiajia, Yang, Jing, Liu, Kaiyan, Lu, Wenhua, Wen, Shijun, Hu, Yumin, Huang, Peng   +9 more
openaire   +1 more source

A posterior program of gene expression is acutely down-regulated after β-catenin-1 inhibition in planarians.

, 2019
(A) Experimental scheme for RNA sequencing. Schmidtea mediterranea adults were fed once with control or β-catenin-1 dsRNA. Tails were collected in trizol 1, 2, 4, and 6 days after feeding for RNA sequencing. Red box indicates tissue collected.
Daniel E. Wagner (7517981), Jared H. Owen (7517975), Aneesha G. Tewari (7517972), Christian P. Petersen (7517978), Peter W. Reddien (7517984)   +4 more
core   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

β-catenin expression.

, 2012
(A) Nuclear β-catenin labeling control in a desmoid tumor. (B) Leiomyoma without β-catenin expression (LM1). (C) Uterine leiomyosarcoma with cytoplasmic β-catenin expression (LMS8).
Eberhard Stoeckle (154353), Anne Floquet (154358), Gaëtan MacGrogan (29233), Frédéric Chibon (154366), Valérie Velasco (154339), Agnès Neuville (154344), Jean-Michel Coindre (154348), Agnès Ribeiro (154334), Gaëlle Pérot (154330), Sabrina Croce (154332), Pauline Lagarde (154336)   +10 more
core   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

MOESM2 of INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification

, 2019
Additional file 2: Figure S1. Wound-healing assay was used to assess the effect of INC280 on the migration ability of MKN28 and MKN45 cells. INC280-treated MKN45 cells showed suppressed migration ability compared with INC280-treated MKN28 cell lines. Figure S2. Effect of INC280 on cell death in MKN28, SNU620, and MKN45 cells.
Sohn, Sung-Hwa, Kim, Bohyun, Sul, Hee, Kim, Yoo, Kim, Hyeong, Kim, Hongtae, Seo, Jong, Koh, Youngho, Zang, Dae   +8 more
openaire   +1 more source