Results 151 to 160 of about 262,733 (310)

Additional file 1: of Suppression of Slit3 induces tumor proliferation and chemoresistance in hepatocellular carcinoma through activation of GSK3β/β-catenin pathway

, 2018
Table S1. Slit3 expression and patient characteristics in cohort 1. Table S2. Slit3 expression and patient characteristics in cohort 2. (PDF 78 kb)
Lui Ng, Chow, Ariel, Man, Johnny, Yau, Thomas, Wan, Timothy, Iyer, Deepak, Kwan, Virginia, Poon, Ronnie, Pang, Roberta, Wai-Lun Law   +9 more
openaire   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Additional file 2: of Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

, 2019
Table S2. Cox regression univariate andmultivariate analyses of prognostic factors in cervical cancer patients. (DOCX 15 kb)
Li, Han, Zhang, Weijing, Yan, Ming, Qiu, Jiaqi, Chen, Jueming, Sun, Xiaoying, Chen, Xiangfu, Song, Libing, Zhang, Yanna   +8 more
openaire   +1 more source

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Additional file 1: of Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

, 2019
Table S1: Clinicopathological characteristics and tumor expression of NUSAP1 in cervical cancer patients. (DOCX 17 kb)
Li, Han, Zhang, Weijing, Yan, Ming, Qiu, Jiaqi, Chen, Jueming, Sun, Xiaoying, Chen, Xiangfu, Song, Libing, Zhang, Yanna   +8 more
openaire   +1 more source

Multicohort Validation of Gut Microbiome Signatures for Cholangiocarcinoma Diagnosis and Functional Characterization of Bifidobacterium Pseudocatenulatum

Advanced Science, EarlyView.
This study analyzes gut bacteria in cholangiocarcinoma patients, revealing distinct microbial signatures that enable accurate disease detection. Species‐based diagnostic models achieved over 98% accuracy in identifying cholangiocarcinoma and distinguished it from other liver diseases. The research demonstrates that specific beneficial bacteria suppress
Benchen Rao, Jianwen Jiang, Ruiqing Zhang, Dongya Zhang, Chenchen Zhang, Ang Li, Haifeng Lu, Hua Zhang, Lin Zhou, Wenzhi Guo, Peihao Wen, Jianfeng Xue, Jie Pan, Tuerganaili Aji, Zhou Lan, Xianzhi Jiang, Shusen Zheng, Zujiang Yu, Zhigang Ren   +18 more
wiley   +1 more source

Additional file 1: of Stromal fibroblast activation protein alpha promotes gastric cancer progression via epithelial-mesenchymal transition through Wnt/ β-catenin pathway

, 2018
Table S1. Primers sequences in this study. (DOCX 15 kb)
Liu, Jiuyang, Huang, Chaoqun, Peng, Chunwei, Xu, Fei, Li, Yan, Yutaka, Yonemura, Xiong, Bin, Yang, Xiaojun   +7 more
openaire   +1 more source

Metabologenomic Hallmark‐Based Discovery of Bacterial Thioamides as a New Lead against Drug‐Resistant Pancreatic Cancer

Advanced Science, EarlyView.
A targeted metabologenomic strategy integrating genomic and metabolomic hallmarks enabled the discovery of two new thioamides, thiogochangamides A and B, from bacteria. Their absolute configurations, previously unresolved within the thioviridamide family, were fully assigned through various chemical derivatizations and computational analysis ...
Young Eun Du, Eun Seo Bae, Thinh T. M. Bui, Seok Beom Lee, Dahan Kim, Jin‐Gyeong Park, Yongjoo Park, Soo Yeon Park, Sangwook Kang, Beomsu Lee, Daniel Shin, Yun Pyo Kang, In‐Gyun Lee, Dae‐Duk Kim, Seokhee Kim, Suckchang Hong, Kyuho Moon, Sang Kook Lee, Dong‐Chan Oh   +18 more
wiley   +1 more source

Additional file 1: Figure S1. of Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

, 2017
Effect of glutamine depletion on stem-like SP fraction in pancreatic cancer AsPC-1 cells. Figure S2: Effect of glutaminase on percentage of SP cells in A549 cells. Figure S3: Effect of glutamine deprivation on neurosphere formation capacity of glioblastoma stem cells. Figure S4.
Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Yang, Jing, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu, Huang, Peng   +9 more
openaire   +1 more source

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source