Results 151 to 160 of about 1,062,506 (300)

Additional file 1: of TET1-mediated DNA hydroxymethylation activates inhibitors of the Wnt/β-catenin signaling pathway to suppress EMT in pancreatic tumor cells

, 2019
Table S1. Primers in this study (DOCX 18 kb) (DOCX 19 kb)
Wu, Jian, Li, Hongzhe, Shi, Minmin, Zhu, Youwei, Ma, Yang, Zhong, Yiming, Xiong, Cheng, Chen, Hao, Peng, Chenghong   +8 more
openaire   +1 more source

Identification and characterisation of a novel integral membrane protein, shrew-1 that complexes with adherens junctions in polarised cells [PDF]

, 2005
In an attempt to search for potential candidate molecules involved in the pathogenesis of endometriosis, a novel 2910 bp cDNA encoding a putative 411 amino acid protein, shrew-1 was discovered. By computational analysis it was predicted to be an integral
Bharti, Sanita
core  

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

Advanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan, Yaqing Wen, Yushan Zhang, Lan Zhang, Jianjian Zhu, Zhen Tang, Ling Jiang, Chuhan Fu, Shu Zhou, Keyi Zhang, Jiangfeng Huang, Li Lei, Jing Chen, Qinghai Zeng   +13 more
wiley   +1 more source

Additional file 1: of Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway

, 2018
Binding Mode Prediction of Azoramide and figure legend of additional file 2. (DOCX 31 kb)
Ruan, Banjun, Zhu, Zheng, Yan, Zhao, Yang, Wei, Zhai, Dongsheng, Wang, Li, Ye, Zichen, Lu, Huanyu, Xiang, An, Liang, Jingwei, Jiang, Yinghao, Xu, Chengming, Wang, Zhenyu, Wei, Ming, Lei, Xiaoying, Cao, Xiaorui, Lu, Zifan   +16 more
openaire   +1 more source

Gαi1/3 Are Essential for BMP2‐Induced Osteogenesis by Bridging BMP Receptors to the Gab1 Signaling Complex

Advanced Science, EarlyView.
The Gαi1/3 protein is a crucial connecting protein closely related to the signal transduction process of bone formation‐related cytokines such as BMP2. Gαi1/3 mediates downstream signaling pathways such as Smads and MAPK by binding to adaptor proteins like Gab1, thereby promoting the osteogenic effect of BMSCs.
Huajian Shan, Chaowen Bai, Yifei Zhu, Chenyang Xu, Sonngtao Li, Qize Sun, Chang She, Jinyu Bai, Cong Cao, Yitian Yang, Xiaozhong Zhou   +10 more
wiley   +1 more source

MOESM2 of INC280 inhibits Wnt/β-catenin and EMT signaling pathways and its induce apoptosis in diffuse gastric cancer positive for c-MET amplification

, 2019
Additional file 2: Figure S1. Wound-healing assay was used to assess the effect of INC280 on the migration ability of MKN28 and MKN45 cells. INC280-treated MKN45 cells showed suppressed migration ability compared with INC280-treated MKN28 cell lines. Figure S2. Effect of INC280 on cell death in MKN28, SNU620, and MKN45 cells.
Sohn, Sung-Hwa, Kim, Bohyun, Sul, Hee, Kim, Yoo, Kim, Hyeong, Kim, Hongtae, Seo, Jong, Koh, Youngho, Zang, Dae   +8 more
openaire   +1 more source

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Additional file 2: of miR-140-5p regulates the odontoblastic differentiation of dental pulp stem cells via the Wnt1/β-catenin signaling pathway

, 2019
The original band of DMP-1 and DSPP in Figs. 3 and 5. The DMP-1 and DSPP proteins were detected by Western blot. (PPTX 308 kb)
Lu, Xiaohui, Chen, Xi, Xing, Jing, Lian, Min, Huang, Dan, Lu, Yuanzhou, Feng, Guijuan, Feng, Xingmei   +7 more
openaire   +1 more source

Role and regulation of miR-483 in cancer [PDF]

, 2012
The hsa-mir-483 locus is located at chromosome 11p15.5 within intron 2 of the IGF2 locus. Because of its location, de-regulated in Wilms’ tumor and other neoplasia, I hypothesized that this microRNA had a potential role in tumors.
Veronese, Angelo
core  

AARS1‐Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8+T Cells in Smoking‐Related Emphysema

Advanced Science, EarlyView.
Exposure to CS causes an elevation of AARS1 levels, which increases the levels of RUNX3 lactylation at the K193 site and increases protein levels of RUNX3 through inhibition of autolysosomal degradation. Elevated RUNX3 levels promote CD8+T cell activation and augment their cytotoxicity, which induces alveolar epithelial cell death and facilitates the ...
Ying Zhu, Jiaheng Lin, Yifan Li, Qiaoqiao Zhou, Min Yu, Cheng Cheng, Kang Chang, Dang Lin, Tao Bian, Yan Wu, Lu Lu, Haibo Xia, Qizhan Liu   +12 more
wiley   +1 more source