Results 131 to 140 of about 262,733 (310)

Inhibiting β-Catenin by β-Carboline-Type MDM2 Inhibitor for Pancreatic Cancer Therapy

Frontiers in Pharmacology, 2018
The β-catenin and MDM2 oncoproteins are overexpressed and constitutively activated in human pancreatic cancer and contribute to its initiation, progression, and metastasis.
Jiang-Jiang Qin, Wei Wang, Wei Wang, Xin Li, Hemantkumar Deokar, John K. Buolamwini, Ruiwen Zhang, Ruiwen Zhang   +7 more
doaj   +1 more source

Additional file 6: of RUNX1 promotes tumour metastasis by activating the Wnt/β-catenin signalling pathway and EMT in colorectal cancer

, 2019
Table S2. Chip primer sequenced used for quantitative real-time PCR. (DOC 29 kb)
Li, Qingyuan, Lai, Qiuhua, He, Chengcheng, Fang, Yuxin, Yan, Qun, Zhang, Yue, Wang, Xinke, Gu, Chuncai, Wang, Yiqing, Ye, Liangying, Han, Lu, Lin, Xin, Chen, Junsheng, Cai, Jianqun, Li, Aimin, Liu, Side   +15 more
openaire   +1 more source

The actin cytoskeleton and the nuclear translocation of β-catenin in human oesophageal squamous carcinoma cell lines [PDF]

, 2006
Student Number : 9906751K - MSc dissertation - School of Molecular and Cell Biology - Faculty of ScienceIn addition to its crucial role in cell adhesion, β-catenin is also known to augment gene expression by forming a complex with lymphoid enhancer ...
Dahan, Yael-Leah
core  

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Advanced Science, EarlyView.
Hepatocytes are subjected to increased membrane tension along with lipid accumulation. Loss of PIEZO1 exacerbates high‐fat diet‐induced MASLD in mice. Activation of PIEZO1 alleviates high‐fat diet‐induced MASLD in mice. PIEZO1 negatively regulates de novo lipogenesis through activation of CaMKK2‐AMPK pathway. ABSTRACT Liver is a central organ for lipid
Hui Chen, Qimeng Wang, Ke Yang, Qinghai Lian, Xuyun Peng, Zhiyong Gong, Xinyi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jinghui Guo, Geyang Xu, Qi Zhang   +14 more
wiley   +1 more source

Cepharanthine suppresses APC-mutant colorectal cancers by down-regulating the expression of β-catenin

Natural Products and Bioprospecting
The aberrant activation of the Wnt/β-catenin signaling pathway is closely associated with the development of various carcinomas, especially colorectal cancers (CRCs), where adenomatous colorectal polyposis (APC) mutations are the most frequently observed,
Guifeng Su, Dan Wang, Qianqing Yang, Lingmei Kong, Xiaoman Ju, Qihong Yang, Yiying Zhu, Shaohua Zhang, Yan Li   +8 more
doaj   +1 more source

MOESM1 of A tannin compound from Sanguisorba officinalis blocks Wnt/β-catenin signaling pathway and induces apoptosis of colorectal cancer cells

, 2019
Additional file 1. Minimum standards of reporting checklist.
Li, Wa, Yang, Chun-juan, Wang, Li-qian, Wu, Juan, Dai, Cong, Yuan, Yue-mei, Li, George, Yao, Mei-cun   +7 more
openaire   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Additional file 1: of The lncRNA NEAT1 activates Wnt/β-catenin signaling and promotes colorectal cancer progression via interacting with DDX5

, 2018
Supplemental materials and methods. (DOCX 20 kb)
Zhang, Meng, Weng, Weiwei, Zhang, Qiongyan, Wu, Yong, Ni, Shujuan, Tan, Cong, Xu, Midie, Sun, Hui, Liu, Chenchen, Wei, Ping, Du, Xiang   +10 more
openaire   +1 more source

Mechanical Regulation of Wnt/β-catenin Signaling in Bone Cells [PDF]

, 2010
poster abstractThe Wnt/β-catenin signaling pathway is an important regulatory pathway in development and maintenance of various tissues, including bone. Active Wnt interacts with the frizzled/LRP receptor activating dishevelled, which in turn inactivates
Gerard-O’Riley, R., Hum, J.M., Pavalko, F.M., Young, S.R.L.   +3 more
core  

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source