Results 131 to 140 of about 1,062,506 (300)

MOESM1 of Knockdown of AGGF1 inhibits the invasion and migration of gastric cancer via epithelialâ mesenchymal transition through Wnt/β-catenin pathway

, 2019
Additional file 1: Table S1. Characteristics of the 4 kinds of human gastric cancer cell lines used in the study.
Yao, Han-Hui, Zhao, Ya-Jun, He, Yi-Fu, Huang, Da-Bing, Wang, Wei   +4 more
openaire   +1 more source

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source

Table_1_SIRT6 Is Involved in the Progression of Ovarian Carcinomas via β-Catenin-Mediated Epithelial to Mesenchymal Transition.DOC

, 2018
SIRT6 is involved in various cellular signaling pathways including those involved in tumorigenesis in association with β-catenin. However, the role of SIRT6 in tumorigenesis has been controversially reported and the studies on the role of SIRT6 in ...
Sang Hoon Ha (834619), Ho Lee (453255), Myoung Ja Chung (453256), Byung-Hyun Park (518987), Ho Sung Park (134939), Woo Sung Moon (134941), Usama Khamis Hussein (5989955), Kyoung Min Kim (436671), Kyu Yun Jang (134932), Sang Jae Noh (134934), Jun Sang Bae (453251), See-Hyoung Park (246508), Dong Hyu Cho (5989958)   +12 more
core   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Additional file 1: Table S1. of Effects of hepatitis C virus core protein and nonstructural protein 4B on the Wnt/β-catenin pathway

, 2017
Primers for PCR. (DOCX 17Â kb)
Jiang, Xiao-Hua, Xie, Yu-Tao, Cai, Ya-Ping, Ren, Jing, Ma, Tao   +4 more
openaire   +1 more source

Modulation of Lung Adenocarcinoma by Phosphorylated FOXN3‐Mediated Transcriptional Inactivation of p53

Advanced Science, EarlyView.
In non‐tumorous lung tissues, FOXN3 promotes the transcriptional activation of p53 by facilitating its recruitment to target promoters, thereby suppressing lung tumorigenesis through activation of the p53 signaling pathway. Conversely, in lung adenocarcinoma tissues, hyperphosphorylated FOXN3 dissociates from the promoters of p53‐responsive genes and ...
Jinjin Yu, Jingyu Yu, Suhui Wang, Xinghong Hu, Lele Jin, Nan Wu, Yuhan Ni, Xueying Zhang, Chengling Zhao, Jihong Zhou, Yong Zhang, Baofa Sun, Hongxing Zhang, Chunfu Zheng, Song Guo Zheng, Wei Li, Xinxing Zhu   +16 more
wiley   +1 more source

Concomitant loss of p120-catenin and β-catenin membrane expression and oral carcinoma progression with E-cadherin reduction.

PLoS ONE, 2013
The binding of p120-catenin and β-catenin to the cytoplasmic domain of E-cadherin establishes epithelial cell-cell adhesion. Reduction and loss of catenin expression degrades E-cadherin-mediated carcinoma cell-cell adhesion and causes carcinomas to ...
Kazunobu Sasaya, Haruka Sudo, Genta Maeda, Shuichi Kawashiri, Kazushi Imai   +4 more
doaj   +1 more source

Additional file 2: of Nucleolar and spindle associated protein 1 promotes metastasis of cervical carcinoma cells by activating Wnt/β-catenin signaling

, 2019
Table S2. Cox regression univariate andmultivariate analyses of prognostic factors in cervical cancer patients. (DOCX 15 kb)
Li, Han, Zhang, Weijing, Yan, Ming, Qiu, Jiaqi, Chen, Jueming, Sun, Xiaoying, Chen, Xiangfu, Song, Libing, Zhang, Yanna   +8 more
openaire   +1 more source

Targeting GALNT7 Disrupts the TAZ O‐GalNAcylation Feedback Loop to Suppress Gallbladder Cancer Progression

Advanced Science, EarlyView.
Aberrant GALNT7‐mediated O‐GalNAcylation stabilizes TAZ to drive gallbladder cancer progression through a feed‐forward transcriptional loop. Structure‐based screening identifies Olaparib as a potent GALNT7 antagonist that disrupts this oncogenic axis, providing an immediate therapeutic strategy for this aggressive malignancy.
Peng Qiu, Ming Zhang, Yunxiang Feng, Yibo Deng, Kai Zhao, Xiangyu Li, Yun Lu, Li Tian, Tao Yang, Wei Yao, Jianming Wang, Zhengdong Deng   +11 more
wiley   +1 more source

Loss of β-catenin in cholangiocytes promotes hepatocyte reprogramming and vascular remodeling during murine cholestasis

Cell Communication and Signaling
Background & aims The Wnt/β-catenin signaling pathway is critical for liver homeostasis. We have previously shown that hepatocyte β-catenin plays a pleiotropic role in cholestatic injury.
Matthew Carson, Jamie Fornsaglio, Ridgeway Case IV, Rithwik Aggarwal, Vik Meadows, Chang Kyung Kim, Laura Molina, Pamela Cornuet, Jia-Jun Liu, Silvia Liu, Kari Nejak-Bowen   +10 more
doaj   +1 more source