Results 171 to 180 of about 886,342 (318)

Translocation of β-catenin.

, 2014
(A) The protein expression of p-GSK-3β (Tyr 216) which is active-GSK-3β, p-β-catenin which is inactive β-catenin and active-β-catenin were detected by western-blot in vitro and in vivo.
Fan Wang (135182), Ling Xu (117663), Weiqi Dai (5651926), Chengfen Wang (519041), Kan Chen (453104), Jingjing Li (7654), Jie Lu (139953), Yugang Wang (317500), Ping Cheng (289811), Yan Zhang (8098), Yuanyuan Zheng (481854), Chuanyong Guo (2586304), Miao Shen (292694), Jing Yang (13969), Huawei Zhang (424729), Yingqun Zhou (311971), Rong Zhu (172093)   +16 more
core   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source

Additional file 1: of Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway

, 2018
Binding Mode Prediction of Azoramide and figure legend of additional file 2. (DOCX 31 kb)
Ruan, Banjun, Zhu, Zheng, Yan, Zhao, Yang, Wei, Zhai, Dongsheng, Wang, Li, Ye, Zichen, Lu, Huanyu, Xiang, An, Liang, Jingwei, Jiang, Yinghao, Xu, Chengming, Wang, Zhenyu, Wei, Ming, Lei, Xiaoying, Cao, Xiaorui, Lu, Zifan   +16 more
openaire   +1 more source

Aptamer‐Targeted PrPC Drives Colorectal Cancer Metastasis via a LYN‐STAT3 Complex and Enables Liquid Biopsy Detection

Advanced Science, EarlyView.
The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang, Hongyu Wu, Chaojing Zheng, Hao Zhang, Xiaoqiu Wu, Jiaqi Wang, Zewen Chang, Jun Xiang, Yunxiao Liu, Chenkai Zhang, Yuliuming Wang, Hao Jiang, Yuchen Zhong, Jun Luo, Ying Chen, NaNa Zhang, Weiyuan Zhang, Ziming Yuan, ChaoXia Zou, Weihong Tan, Meng Wang, Hanqing Hu, Tao Bing, Guiyu Wang   +23 more
wiley   +1 more source

Additional file 1: Table S1. of Stress-inducible Protein-1 promotes metastasis of gastric cancer via Wnt/β-catenin signaling pathway

, 2018
Antibodies Used. (DOCX 17 kb)
Huang, Linlin, Zhai, Ertao, Cai, Shirong, Lin, Yi, Liao, Junbin, Jin, Huilin, Peng, Sui, Xu, Lixia, Chen, Minhu, Zeng, Zhirong   +9 more
openaire   +1 more source

Supplementary Figure S8 from Gas6/AXL Signaling Regulates Self-Renewal of Chronic Myelogenous Leukemia Stem Cells by Stabilizing β-Catenin

, 2017
Gas6/AXL ligation stabilizes β-catenin in a AKT-dependent manner in CML CD34+ cells.
Jingfeng Zhou (7858409), Danian Nie (12209365), Xin Du (208780), Yuhong Lu (8449824), Yanli Jin (4118275), Chang Liu (35901), Juan Li (146180), Yangqiu Li (1495978), Jingxuan Pan (451842)   +8 more
core   +1 more source

PGK1 Suppresses CD8+ T Cell‐Mediated Antitumor Immunity Through CCL2/CCR2/Tumor‐Associated Macrophages Axis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
PGK1 in tumor cells upregulates CCL2 expression through activation of the AKT/GSK‐3β/β‐catenin signaling axis, thereby promoting the recruitment and M2 polarization of TAMs and ultimately impairing the infiltration and activation of CD8+ T cells within the HCC tumor microenvironment. ABSTRACT Patients with advanced hepatocellular carcinoma (HCC) have a
Xi Liu, Jianpeng Liu, Zhihao Zhang, Xizhi Yu, Junjie Qian, Limin Ding, Qinchuan Wu, Zhe Yang, Xing‐Yu Luo, Xinjiang Ding, Rong Su, Xiaobo Yu, Yiting Qiao, Shengyong Yin, Haiyang Xie, Lin Zhou, Yuanxing Liu, Shusen Zheng   +17 more
wiley   +1 more source

Transport of Golgi-localized β-catenin p-S47 by KIF11 or KIFC3 induces primary ciliogenesis

Molecules and Cells
: Primary cilium is an important hub for cell signaling and dysregulation of primary cilia assembly and disassembly is associated with the development of cancer and chemotherapeutic drug resistance, as well as the genetic disorders collectively known as ...
Na Yeong Lee, Mi-Lang Kyun, Ji Eun Yu, Sun-Ok Kim, Key-Hwan Lim, Kyung Ho Lee   +5 more
doaj   +1 more source

Additional file 2: of Downregulation of RNF128 activates Wnt/β-catenin signaling to induce cellular EMT and stemness via CD44 and CTTN ubiquitination in melanoma

, 2019
Table S1. Sequences of primer for real-time polymerase chain reaction (DOCX 14 kb)
Wei, Chuan-Yuan, Zhu, Meng-Xuan, Yang, Yan-Wen, Zhang, Peng-Fei, Yang, Xuan, Peng, Rui, Gao, Chao, Lu, Jia-Cheng, Wang, Lu, Deng, Xin-Yi, Lu, Nan-Hang, Qi, Fa-Zhi, Gu, Jian-Ying   +12 more
openaire   +1 more source

Nucleic Acid Therapeutics for “Undruggable” Cancer Targets: Mechanisms, Challenges, and Prospects

Advanced Science, EarlyView.
Nucleic acid therapeutics bypass the structural limitations of conventional drugs by targeting mRNA rather than proteins. This review examines how antisense oligonucleotides, siRNAs, miRNAs, aptamers, and mRNA vaccines intervene against historically undruggable oncoproteins including Ras, MYC, and p53, highlighting mechanistic advances, delivery ...
Feng Xu, Ke Wang, Kaizhong Lu, Tianlun Hou, Yuan Chen, Xian Wang, Hongchuan Jin   +6 more
wiley   +1 more source