Results 211 to 220 of about 101,136 (248)

Repurposing of Inhibitors of Plasmodial Aspartate Transcarbamoylase Toward Trypanosoma Cruzi

ChemMedChem, Volume 21, Issue 6, 27 March 2026.
Aspartate transcarbamoylase (ATC) catalyzes the committed and rate‐limiting step in the pyrimidine de novo biosynthesis pathway. While previously suggested to be a potential target for antimalarial, antitubercular, and antioncologic drug discovery, we hypothesized that an existing compound library of ATC inhibitors designed from one scaffold by ...
Siyao Chen, Monica Cal, Queenie Mondile, Rick Oerlemans, Mukim Mayur Shashikant, Alexander S. S. Dömling, Özlem Tastan Bishop, Pascal Mäser, Matthew R. Groves   +8 more
wiley   +1 more source

β-Galactosidase- and Photo-Activatable Fluorescent Probes for Protein Labeling and Super-Resolution STED Microscopy in Living Cells. [PDF]

Molecules
Khan TA, Stoldt S, Bossi ML, Belov VN, Hell SW.   +4 more
europepmc   +1 more source

Validation of high-sensitivity assays to quantitate cerebrospinal fluid and serum β-galactosidase activity in patients with GM1-gangliosidosis. [PDF]

Mol Ther Methods Clin Dev
Quadrini KJ, Vrentas C, Duke C, Wilson C, Hinderer CJ, Weinstein DA, Al-Zaidy SA, Browne SE, Wilson JM, Ni YG.   +9 more
europepmc   +1 more source

Adhesive Photoinitiator Constructs Polymer Jackets on Enzymes: Direct, Release‐Free Cytosolic Delivery

Angewandte Chemie, Volume 138, Issue 11, 9 March 2026.
A supramolecular adhesive photoinitiator, GuCD⊃BP‐SH, overcomes a central dilemma in enzyme therapeutics. The initiator, featuring a guanidinium‐modified cyclodextrin (GuCD) host, triggers formation of a semi‐permeable polymer jacket directly on an enzyme.
Shuran He, Soumen Ghosh, Kou Okuro
wiley   +2 more sources

Design strategies and biological applications of β-galactosidase fluorescent sensor in ovarian cancer research and beyond. [PDF]

RSC Adv
Li L, Jia F, Li Y, Peng Y.
europepmc   +1 more source

Self‐Immolative Systems in Diagnostic and Therapeutic Applications

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Self‐Immolative Systems enable the precise, residue‐free release of active molecules, drugs, probes, or sensors, via cyclization or elimination, triggered by specific stimuli. Their versatility drives advances in drug delivery, diagnostics, nanotechnology, materials chemistry, and biosensing, offering chemists control over molecular activation and ...
Windbedema Prisca Ouédraogo, Thomas Cailly, Valérie Collot   +2 more
wiley   +1 more source

Cryo-EM of soft-landed β-galactosidase: Gas-phase and native structures are remarkably similar. [PDF]

Sci Adv
Esser TK, Böhning J, Önür A, Chinthapalli DK, Eriksson L, Grabarics M, Fremdling P, Konijnenberg A, Makarov A, Botman A, Peter C, Benesch JLP, Robinson CV, Gault J, Baker L, Bharat TAM, Rauschenbach S.   +16 more
europepmc   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Protocol to detect senescence-associated β-galactosidase and immunoperoxidase activity in fresh-frozen murine tissues. [PDF]

STAR Protoc
Idelfonso-García OG, Pacheco-Rivera R, Alarcón-Sánchez BR, Serrano-Luna J, Baltiérrez-Hoyos R, Vásquez-Garzón VR, Muriel P, Villa-Treviño S, Pérez-Carreón JI, Arellanes-Robledo J.   +9 more
europepmc   +1 more source