Results 261 to 270 of about 143,975 (276)

Cryo-EM of soft-landed β-galactosidase: Gas-phase and native structures are remarkably similar. [PDF]

Sci Adv
Esser TK, Böhning J, Önür A, Chinthapalli DK, Eriksson L, Grabarics M, Fremdling P, Konijnenberg A, Makarov A, Botman A, Peter C, Benesch JLP, Robinson CV, Gault J, Baker L, Bharat TAM, Rauschenbach S.   +16 more
europepmc   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

In vivo mechanical loading rapidly activates beta-catenin signaling in osteocytes through a prostaglandin mediated mechanism [PDF]

Aarden, Ajubi, Ajubi, Almeida, Armstrong, B. Javaheri, Bonewald, Bonewald, Boyden, Case, Case, Castellone, Chennimalai Kumar, Cherian, D.L. Ellies, Dallas, DasGupta, Donaldson, G. Thiagarajan, Galea, Genetos, Genetos, Gong, Harris, Javaheri, Jing, Johnson, Johnson, Jorgensen, Kalajzic, Kamel, Kato, Kitase, Klein-Nulend, Klein-Nulend, Klein-Nulend, Klein-Nulend, Komori, Kunnel, Lau, Li, Little, Loiselle, Lu, M.A. Kamel, M.L. Johnson, Mantila Roosa, Marotti, Moustafa, N. Lara-Castillo, N.A. Kim-Weroha, Nicolella, Noursadeghi, Patel, R.E. Krumlauf, Rath Bonivtch, Reyes, Robinson, Robling, Rubin, Sample, Santos, Sawakami, Saxon, Schaffler, Skerry, Sunters, Thiagarajan, Tu, Webster, Willie, Yang, You   +72 more
core   +1 more source

Protocol to detect senescence-associated β-galactosidase and immunoperoxidase activity in fresh-frozen murine tissues. [PDF]

STAR Protoc
Idelfonso-García OG, Pacheco-Rivera R, Alarcón-Sánchez BR, Serrano-Luna J, Baltiérrez-Hoyos R, Vásquez-Garzón VR, Muriel P, Villa-Treviño S, Pérez-Carreón JI, Arellanes-Robledo J.   +9 more
europepmc   +1 more source

Glia Regulate the Timing of Photoreceptor Differentiation in the Drosophila Visual System

Glia, Volume 74, Issue 2, February 2026.
Activation of EGFR signaling in sub‐retinal glia is required for timing photoreceptor differentiation in the Drosophila visual system. ILP3 and ILP6 are downstream targets of the EGFR pathway in sub‐retinal glia, which activate insulin signaling in photoreceptor precursor cells in the developing retina.
Qian Ren, Wen‐Tzu Chang, Yong Rao
wiley   +1 more source

Excited-State-Altering Ratiometric Fluorescent Probes for the Response of <i>β</i>-Galactosidase in Senescent Cells. [PDF]

Molecules
Han YN, Dong L, Sun LL, Li WJ, Xie J, Li C, Ren S, Zhang Z, Han HH, Zhang Z.   +9 more
europepmc   +1 more source

WTAP Contributes to Periodontitis Pathogenesis by Promoting PDLSC Senescence and Impairing Osteogenic Differentiation via m6A‐Dependent Regulation of TP53BP1

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Background Periodontitis, a chronic inflammatory disease, represents the primary cause of tooth loss in Chinese adults. Wilms tumor 1‐associating protein (WTAP) is a key component of the N6‐methyladenosine (m6A) methyltransferase complex, and has an unclear role in periodontitis pathogenesis, particularly concerning its regulatory functions in
Menglin Xiong, Tingting Wang, Yuan Liu
wiley   +1 more source

A renal clearable fluorogenic probe for in vivo β-galactosidase activity detection during aging and senolysis. [PDF]

Nat Commun
Rojas-Vázquez S, Lozano-Torres B, García-Fernández A, Galiana I, Perez-Villalba A, Martí-Rodrigo P, Palop MJ, Domínguez M, Orzáez M, Sancenón F, Blandez JF, Fariñas I, Martínez-Máñez R.   +12 more
europepmc   +1 more source

Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Sarcopenia is a prevalent age‐related disorder characterized by progressive muscle atrophy. Impaired balance is one of its most critical clinical consequences, often leading to falling and even bone fractures. As the cerebellum plays a central role in regulating motor coordination, elucidating the molecular mechanisms underlying ...
Xin Jiao, Zengguang Wang, Hanwen Chang, Yongjin Li, Binbin Wang, Xinfa Shao, Yuxin Zhang, Yixuan Lin, Xinlin Jia, Xianhao Zhou, Wentao Li, Dinghao Luo, Tanjun Deng, Xingzuan Lin, Chen Xu, Yaokai Gan, Dongyun Gu   +16 more
wiley   +1 more source

Detection and Elimination of Senescent Cells with a Self-Assembled Senescence-Associated β-Galactosidase-Activatable Nanophotosensitizer. [PDF]

J Med Chem
Chu JCH, Xiong J, Wong CTT, Wang S, Tam DY, García-Fernández A, Martínez-Máñez R, Ng DKP.   +7 more
europepmc   +1 more source