Results 51 to 60 of about 886,029 (245)

BCG HSP70 Reprograms Macrophages via Central Trained Immunity to Suppress Prostate Cancer

Advanced Science, EarlyView.
BCG‐derived HSP70 (Dnak) safely induces central trained immunity via epigenetic, metabolic, and O‐GlcNAcylation reprogramming of bone marrow progenitors, driving tumor‐associated macrophages toward an M1‐like phenotype to suppress prostate cancer. ABSTRACT Trained immunity offers a promising yet clinically challenging strategy for cancer immunotherapy,
Peng Liu, Kangkang Liu, Keruo Wang, Heyang Guan, Jiaming Fan, Taipeng Li, Jiaru Hao, Zeyuan Wang, Yongchao Yan, Jiatong Chen, Yuan Ma, Yang Yang, Yuanjie Niu   +12 more
wiley   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Children’s residential exposure to selected allergens and microbial indicators: endotoxins and (1→3)-β-D-glucans [PDF]

, 2013
Objectives: The study was aimed at assessment of exposure to endotoxins, (1→3)-β-D-glucans and mite, cockroach, cat, dog allergens present in settled dust in premises of children as agents which may be significantly correlated with the occurrence of ...
Hanke, Wojciech, Wojciech Sobala, Bródka, Karolina, Kozajda, Anna, Małgorzata Sowiak, Sowiak, Małgorzata, Wojciech Hanke, Polańska, Kinga, Kinga Polańska, Joanna Jurewicz, Szadkowska-Stańczyk, Irena, Karolina Bródka, Sobala, Wojciech, Jurewicz, Joanna, Anna Kozajda, Irena Szadkowska-Stańczyk   +15 more
core   +2 more sources

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Biological Effects of Yeast β-Glucans [PDF]

, 2010
β-Glucans are glucose polymers that naturally occur in yeasts, molds, algae, mushrooms, bacteria, oats and barley. Immunostimulation is one of the most important properties of β-glucans. They are classified as biological response modifiers and because of
Petravić-Tominac, Vlatka, Slobodan Grba, Siniša Srečec, Srečec, Siniša, Panjkota-Krbavčić, Ines, Vidović, Lana, Vlatka Petravić-Tominac, Grba, Slobodan, Vesna Zechner-Krpan, Zechner-Krpan, Vesna, Ines Panjkota-Krbavčić, Lana Vidović   +11 more
core   +1 more source

Modulation of Animal and Human Hematopoiesis by β-Glucans: A Review

Molecules, 2011
β-Glucans are cell wall constituents of bacteria, yeast, fungi, and plants. They are not expressed in mammalian cells, but they are recognized by mammalian cells as pathogen-associated molecular patterns by pattern recognition receptors and thus act as ...
Milan Pospíšil, Michal Hofer
doaj   +1 more source

Development of Fish Immunity and the Role of β-Glucan in Immune Responses

Molecules, 2020
Administration of β-glucans through various routes, including immersion, dietary inclusion, or injection, have been found to stimulate various facets of immune responses, such as resistance to infections and resistance to environmental stress.
Marianna V. Rodrigues, Fábio S. Zanuzzo, João Fernando A. Koch, Carlos Alberto F. de Oliveira, Petr Sima, Vaclav Vetvicka   +5 more
doaj   +1 more source

Production of stable emulsions using β-glucans extracted from Pleurotus ostreatus to encapsulate oxidizable compounds [PDF]

, 2021
The basidiomycete Pleurotus ostreatus is a sustainable food source known to be rich in β-glucans, functional compounds in mushrooms recognized for their numerous health, nutraceutical, and physicochemical properties.
Lavelli, Vera, Francesca Gallotti, Christelle Turchiuli, F. Gallotti, V. Lavelli, Turchiuli, Christelle, Gallotti, Francesca, C. Turchiuli, Vera Lavelli   +8 more
core   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources