Results 51 to 60 of about 54,273 (155)

Induction of MRSA Biofilm by Low-Dose β-Lactam Antibiotics: Specificity, Prevalence and Dose-Response Effects

Dose-Response, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis.
Mandy Ng, Samuel B. Epstein, Mary T. Callahan, Brian O. Piotrowski, Gary L. Simon, Afsoon D. Roberts, John F. Keiser, Jeffrey B. Kaplan   +7 more
doaj   +1 more source

Exposure of clinical MRSA heterogeneous strains to β-lactams redirects metabolism to optimize energy production through the TCA cycle. [PDF]

PLoS ONE, 2013
Methicillin-resistant Staphylococcus aureus (MRSA) has emerged as one of the most important pathogens both in health care and community-onset infections. The prerequisite for methicillin resistance is mecA, which encodes a β-lactam-insensitive penicillin
Mignon A Keaton, Roberto R Rosato, Konrad B Plata, Christopher R Singh, Adriana E Rosato   +4 more
doaj   +1 more source

A novel method to depurate β-lactam antibiotic residues by administration of a broad-spectrum β-lactamase enzyme in fish tissues

Fisheries and Aquatic Sciences, 2016
As a novel strategy to remove β-lactam antibiotic residues from fish tissues, utilization of β-lactamase, enzyme that normally degrades β-lactam structure-containing drugs, was explored.
Young-Sik Choe, Ji-Hoon Lee, Soo-Geun Jo, Kwan Ha Park   +3 more
doaj   +1 more source

Teicoplanin versus β-lactam for febrile patients with Staphylococcus-like bacteremia: focus on methicillin-susceptible Staphylococcus aureus bacteremia

BMC Infectious Diseases, 2021
Background Many studies have shown that vancomycin is inferior to β-lactam antibiotics in terms of effectiveness in the treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia.
Ching-Yen Tsai, Chen-Hsiang Lee, I-Ling Chen   +2 more
doaj   +1 more source

Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics

Antibiotics, 2023
Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water ...
Sarmistha Biswal, Karina Caetano, Diamond Jain, Anusha Sarrila, Tulika Munshi, Rachael Dickman, Alethea B. Tabor, Surya Narayan Rath, Sanjib Bhakta, Anindya S. Ghosh   +9 more
doaj   +1 more source

Synthetic Lethality Reveals Mechanisms of Mycobacterium tuberculosis Resistance to β-Lactams

mBio, 2014
Most β-lactam antibiotics are ineffective against Mycobacterium tuberculosis due to the microbe’s innate resistance. The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains has prompted interest to repurpose this class of ...
Shichun Lun, David Miranda, Andre Kubler, Haidan Guo, Mariama C. Maiga, Kathryn Winglee, Shaaretha Pelly, William R. Bishai   +7 more
doaj   +1 more source

Additional file 2: of Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens

, 2019
Table S2.. Multivariate analysis of 90-day all-cause mortality due to neutropenic pneumonia. (DOCX 15 kb)
Hyeri Seok, Ko, Jae-Hoon, Peck, Kyong, Kim, Ji-Yeon, Lee, Ji, Park, Ga, Cho, Sun, Cheol-In Kang, Lee, Nam, Chung, Doo   +9 more
openaire   +1 more source

Additional file 1: of Treatment of community-onset pneumonia in neutropenic cancer patients: β-lactam monotherapy versus combination antibiotic regimens

, 2019
Table S1. Causative pathogens of neutropenic pneumonia. (DOCX 15 kb)
Hyeri Seok, Ko, Jae-Hoon, Peck, Kyong, Kim, Ji-Yeon, Lee, Ji, Park, Ga, Cho, Sun, Cheol-In Kang, Lee, Nam, Chung, Doo   +9 more
openaire   +1 more source

Profiles of phenotype resistance to antibiotic other than β-lactams in Klebsiella pneumoniae ESBLs-producers, carrying blaSHV genes.

Folia Histochemica et Cytobiologica, 2011
Extended spectrum β-lactamases production is one of the most common mechanism of resistance to extended spectrum β-lactam antibiotics is increasing worldwide. Twenty five strains of Klebsiella pneumoniae isolated from clinical specimens were tested. Based on the phenotypic confirmatory test all these strains were defined as ESBL producers named ESBL(+).
Małgorzata Krawczyk, Robert Milewski, Tomasz Hauschild, Andrzej Szpak, Piotr Wieczorek, Dominika Ojdana, Paweł Sacha, Katarzyna Kaczyńska, Elżbieta Tryniszewska   +8 more
openaire   +5 more sources

Conjugation of Polycationic Peptides Extends the Efficacy Spectrum of β‐Lactam Antibiotics

Advanced Science
Antibiotic‐resistant enterococci represent a significant global health challenge. Unfortunately, most β‐lactam antibiotics are not applicable for enterococcal infections due to intrinsic resistance.
Julia Werner, Florian Umstätter, Manuel B. Böhmann, Hannah Müller, Barbro Beijer, Tobias Hertlein, Laura Kaschnitz, Veronika Bram, Christian Kleist, Karel D. Klika, Eric Mühlberg, Gabriel Braune, Sabrina Wohlfart, Martin Gärtner, Silke Peter, Stefan Zimmermann, Uwe Haberkorn, Knut Ohlsen, Heike Brötz‐Oesterhelt, Walter Mier, Philipp Uhl   +20 more
doaj   +1 more source