Results 181 to 190 of about 144,498 (294)

Protective effect of snail secretion filtrate in an in vitro model of mastitis

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Bovine mastitis is inflammation of the mammary gland mainly caused by bacterial infections, with relevant economic costs and implications related to antibiotic resistance. In light of the increasing demand for sustainable therapies, this study evaluated the anti‐inflammatory and antioxidant effects of snail secretion filtrate (SSF ...
Gianluca Antonio Franco, Ylenia Marino, Rosalia Crupi, Davide di Paola, Salvatore Cuzzocrea, Enrico Gugliandolo   +5 more
wiley   +1 more source

Risk of Acute Kidney Injury Associated With Nephrotoxic Burden in Hospitalized Patients: A Scoping Review

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 891-904, April 2026.
Limited evidence exists synthesizing the risk of acute kidney injury (AKI) associated with the concomitant administration of multiple nephrotoxic drugs, and even less examining the concept of nephrotoxic burden. The objective of this scoping review was to (1) identify definitions of nephrotoxic burden; (2) methods used to quantify (use of calculations)
Wafa Alatawi, Jessica L. Wallace, Dhakrit Rungkitwattanakul, Britney A. Stottlemyer, Tiffany L. Tran, Melanie Manis Reida, Sandra L. Kane‐Gill   +6 more
wiley   +1 more source

Quercetin: A Light in the Fight Against MRSA

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Photoactivated quercetin reduces the bacterial load of MRSA in intradermally infected mice. The control of bacterial load is associated with a modulation of the inflammatory response in animals treated with aPDT. ABSTRACT Antimicrobial photodynamic therapy (aPDT) for treating methicillin‐resistant Staphylococcus aureus (MRSA) infections has gained ...
Maria Poliana Leite Galantini, Caroline Vieira Gonçalves, Amanda Kelle Santos Novaes, Caio Oliveira Lopes de Magalhães, Igor Pereira Ribeiro Muniz, Israel Souza Ribeiro, Paulo Henrique Bispo Lima, Maria Elisa Santos Flores, Artur Reis Carvalho, Luisa Carregosa Santos, Daiana Silva Lopes, Juliano Geraldo Amaral, Robson Amaro Augusto da Silva   +12 more
wiley   +1 more source

A Pilot Metagenomic Study Demonstrating Virtual Reality Head Mounted Displays Utilized in Medical Education Are Reservoirs of Viable Pathogenic Microbes

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Metagenomic analysis identified 27 pathogenic bacteria including 4 "ESKAPE" pathogens (Enterobacter sp., Staphylococcus aureus, Klebsiella spp., and Escherichia coli) and numerous organisms associated with ocular infections. A broad range of antimicrobial resistance genes were identified conveying resistance to Methicillin, Aminoglycosides, Macrolides,
Adrian Goldsworthy, Matthew Olsen, Mohd Fairuz Shiratuddin, Simon McKirdy, Rashed Alghafri, Abiola Senok, Hamda Alfalasi, Kok Wai Wong, Lotti Tajouri   +8 more
wiley   +1 more source

The Evaluation of Machine Learning Models Using Matrix‐Assisted Laser Desorption/Ionization Time‐of‐Flight Mass Spectrometry (MALDI–TOF–MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
Machine learning models developed from matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry spectra can rapidly predict antimicrobial resistance in Klebsiella pneumoniae. By transforming routine spectral data into accurate resistance profiles within minutes, this approach could reduce diagnostic delays and support earlier ...
Stephen Mark Edward Fordham
wiley   +1 more source

Nasal Carriage Rate of Biofilm Producing Methicillin Resistant Staphylococcus aureus and Its Associated Factors Among Health Care Workers at Hospital of Central Ethiopia

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
ABSTRACT Not susceptible to methicillin Staphylococcus aureus (MRSA), is a potentially harmful bacteria that is resistant to the most important antimicrobial agents. Because MRSA is so resistant to many antibiotics, it can cause illnesses by forming biofilms.
Wubeshet Mathewos, Abera Kumalo, Takele Teklu, Tigistu Demisse, Muluneh Temesgen, Tariku Chinasho   +5 more
wiley   +1 more source

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

NCY‐1 β‐Lactamase Activity Correlates With Antimicrobial Susceptibility of a Clinical Strain of Nocardia cyriacigeorgica

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This study shows a strong correlation between the β‐lactam susceptibility profile of a clinical isolate of Nocardia cyriacigeorgica and the activity of its β‐lactamase, NCY‐1. Inhibitors of NCY‐1 reduce the minimum inhibitory concentration of amoxicillin.
Julie Couston, Athénaïs Le Marchand, Elisabeth Hodille, Charlotte Genestet, Brune Joannard, Jérôme Feuillard, Yvonne Benito, Oana Dumitrescu, Mickaël Blaise   +8 more
wiley   +1 more source

Structural Interactions of β-Lactam Antibiotics with Mammalian Serum Albumins. [PDF]

Int J Mol Sci
Duszynski K, Sekula B, Talaj J, Bujacz A.   +3 more
europepmc   +1 more source

A Machine Learning‐Based Model for Individualized Prediction of Vancomycin Concentration‐Time Curves in ICU Patients

Pharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
A machine learning–integrated pharmacokinetic model improves individualized prediction of vancomycin concentration–time profiles in ICU patients and outperforms traditional pharmacokinetic models, providing a practical decision‐support tool for precision dosing.
Jing‐Yi Wang, Jiang Hu, Yan Chen, Shan Li, Jin‐Min Peng, Run Dong, Xiao‐Yun Hu, Wei Jiang, Chun‐Yao Wang, Li Weng, Bin Du, the China Critical Care Clinical Trials Group (CCCCTG)   +11 more
wiley   +1 more source