Results 51 to 60 of about 144,498 (294)

A degenerate PCR-based strategy as a means of identifying homologues of aminoglycoside and ß-lactam resistance genes in the gut microbiota [PDF]

, 2014
peer-reviewedBackground: The potential for the human gut microbiota to serve as a reservoir for antibiotic resistance genes has been the subject of recent discussion. However, this has yet to be investigated using a rapid PCR-based approach.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, Ross, R Paul, STANTON, CATHERINE   +4 more
core   +1 more source

Profiles of phenotype resistance to antibiotic other than β-lactams in Klebsiella pneumoniae ESBLs-producers, carrying blaSHV genes.

Folia Histochemica et Cytobiologica, 2011
Extended spectrum β-lactamases production is one of the most common mechanism of resistance to extended spectrum β-lactam antibiotics is increasing worldwide. Twenty five strains of Klebsiella pneumoniae isolated from clinical specimens were tested. Based on the phenotypic confirmatory test all these strains were defined as ESBL producers named ESBL(+).
Małgorzata Krawczyk, Robert Milewski, Tomasz Hauschild, Andrzej Szpak, Piotr Wieczorek, Dominika Ojdana, Paweł Sacha, Katarzyna Kaczyńska, Elżbieta Tryniszewska   +8 more
openaire   +5 more sources

Intrinsic Class D β-Lactamases of Clostridium difficile

mBio, 2018
Clostridium difficile is the causative agent of the deadly C. difficile infection. Resistance of the pathogen to β-lactam antibiotics plays a major role in the development of the disease, but the mechanism of resistance is currently unknown.
Marta Toth, Nichole K. Stewart, Clyde Smith, Sergei B. Vakulenko   +3 more
doaj   +1 more source

Live to cheat another day: bacterial dormancy facilitates the social exploitation of beta-lactamases [PDF]

, 2015
The breakdown of antibiotics by β-lactamases may be cooperative, since resistant cells can detoxify their environment and facilitate the growth of susceptible neighbours. However, previous studies of this phenomenon have used artificial bacterial vectors
A Bloor, A Brooun, A Ross-Gillespie, A Ross-Gillespie, AS Hackman, B Raymond, B Raymond, Ben Raymond, BR Levin, C Dahlberg, D Clark, DA Mitchison, DM Livermore, E Tuomanen, EA Yurtsev, Frances Medaney, G Rolinson, GL Hobby, HC Neu, I Brook, I Brook, JJ Harrison, JL Cottell, JW Bigger, K Datsenko, K Lewis, K Lewis, K Lewis, K Sandoz, L Dugatkin, L Zhou, M Doebeli, M Ghoul, MH Perlin, NQ Balaban, O Ciofu, PS Stewart, R Ellis, R Lenski, R Lenski, R Tacking, Richard J Ellis, RJ Worthington, RM Cozens, RN Jones, S Brown, SA West, SA West, SP Brown, SP Diggle, Tatiana Dimitriu, X-X Zhang, XX Zhang   +52 more
core   +1 more source

Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam

Scientific Reports, 2020
New antigens deriving from -lloyl and -llanyl, major and minor determinants, respectively, were produced for β-lactam antibiotics cefuroxime, cefotaxime, ceftriaxone, meropenem and aztreonam.
Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira   +2 more
doaj   +1 more source

Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity

Nature Communications, 2021
TEM-1 β-lactamase evolved from ancestral enzymes that degraded a variety of β-lactam antibiotics with moderate efficiency and degrades β-lactam antibiotics with a strong preference for penicillins.
Tushar Modi, Valeria A. Risso, Sergio Martinez-Rodriguez, Jose A. Gavira, Mubark D. Mebrat, Wade D. Van Horn, Jose M. Sanchez-Ruiz, S. Banu Ozkan   +7 more
doaj   +1 more source

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

Pathogens, 2021
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute and chronic infections. β-lactam antibiotics including penicillins, carbapenems, monobactams, and cephalosporins play a key role in the treatment of P.
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

Outer membrane vesicles from β-lactam-resistant Escherichia coli enable the survival of β-lactam-susceptible E. coli in the presence of β-lactam antibiotics

Scientific Reports, 2018
Outer membrane vesicles (OMVs) containing various bacterial compounds are released from mainly gram-negative bacteria. Secreted OMVs play important roles in the ability of a bacterium to defend itself, and thus contribute to the survival of bacteria in a
Si Won Kim, S. Park, S. Im, Jung Seok Lee, J. Jung, Tae Won Gong, J. Lazarte, Jaesung Kim, Jong-Su Seo, Jonghwan Kim, Jong-wook Song, H. Jung, Gwang Joong Kim, Y. J. Lee, Suk-kyung Lim, T. Jung   +15 more
semanticscholar   +1 more source

Rhodium-catalysed hydroformylation of N-(2-propenyl)-β-lactams as a key step in the synthesis of functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides [PDF]

, 2010
Biologically relevant functionalised N-[4-(2-oxoazetidin-1-yl)but-1-enyl]acetamides have been prepared in a two-step approach starting from N-(2-propenyl)-beta-lactams, involving initial rhodium-catalysed hydroformylation followed by subjection of the ...
D'hooghe, Matthias, De Kimpe, Norbert, Dekeukeleire, Stijn, Müller, Christian, Vogt, Dieter   +4 more
core   +2 more sources

Comparison of initial empirical antibiotic regimens in severe community-acquired pneumonia: a network meta-analysis

BMC Pulmonary Medicine
Background Severe community-acquired pneumonia (SCAP) remains a leading cause of morbidity and mortality worldwide. Identifying the optimal antibiotic regimen for treating SCAP is crucial for improving patient outcomes.
Min Wang, Jing Zhang, Xiaoming Wang, Qian Wang, Lian Wang, Han Zhuang, Ao Liu   +6 more
doaj   +1 more source