Results 71 to 80 of about 1,201,054 (248)

Contributions of β-lactamase substrate specificity and outer membrane permeability to the antibiotic sheltering of β-lactam-susceptible bacteria [PDF]

RSC Chemical Biology
The use of β-lactam antibiotics is threatened by antibiotic resistant bacteria that produce β-lactamases. These enzymes not only protect the bacteria that produce them but also shelter other bacteria in the same environment that would otherwise be ...
Montserrat Mora-Ochomogo, Mitchell A. Jeffs, Josephine L. Liu, Christopher T. Lohans   +3 more
doaj   +1 more source

Outer membrane vesicles from β-lactam-resistant Escherichia coli enable the survival of β-lactam-susceptible E. coli in the presence of β-lactam antibiotics

, 2018
Outer membrane vesicles (OMVs) containing various bacterial compounds are released from mainly gram-negative bacteria. Secreted OMVs play important roles in the ability of a bacterium to defend itself, and thus contribute to the survival of bacteria in a
Jong-Su Seo, Suk-Kyung Lim, Se Pyeong Im, Jaesung Kim, Jong-Hwan Kim, Tae Sung Jung, Jung Seok Lee, Jae Wook Jung, Gwang Joong Kim, Seong Bin Park, Jong-Wook Song, Young Ju Lee, Si Won Kim, Hyun Suk Jung, Tae Won Gong, Jassy Mary S. Lazarte   +15 more
core   +1 more source

β-lactam antibiotics, recA mutation and SOS response [PDF]

, 2015
The claim that β-lactam antibiotics induce the SOS response, allowing E. coli survival in the presence of low antibiotic concentrations, was evaluated. No association between the recA gene and antibiotic survival rate was found.
Zdravko Podlesnek
core   +1 more source

β-lactam-induced MRSA biofilm [PDF]

, 2014
Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of hospital- and community-associated infections. The formation of adherent clusters of cells known as biofilms is an important virulence factor in MRSA pathogenesis.
Piotrowski, Brian O., Callahan, Mary T., Roberts, Afsoon D., Keiser, John F., Ng, Mandy, Epstein, Samuel B., Kaplan, Jeffrey B., Simon, Gary L.   +7 more
core   +3 more sources

Mechanistic studies of some chemical and biochemical reactions [PDF]

Three aspects of chemical and biochemical reactions were investigated. 1. The relative reactivities of pyrophosphate (phosphorus(V)) and pyro-di-H-phosphonate (phosphorus(III)) and its derivatives have been analysed at various pHs.
Mistry, Dharmit
core   +3 more sources

Characterization of acquired β-lactamases in Pseudomonas aeruginosa and quantification of their contributions to resistance

Microbiology Spectrum
Pseudomonas aeruginosa is a highly problematic opportunistic pathogen that causes a range of different infections. Infections are commonly treated with β-lactam antibiotics, including cephalosporins, monobactams, penicillins, and carbapenems, with ...
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

Tunicamycin and β-Lactams with Five Membered Ring Structures Have Stronger Synergistic Effects Against Gram-Positive Bacteria

Zoonoses
The prevalence of antimicrobial resistance is increasing among gram-positive bacteria, particularly the resistance of methicillin-resistant Staphylococcus aureus (MRSA) to β-lactam antibiotics. Checkerboard minimum inhibitory concentration (MIC) assays,
Xueyangyang Bai, Jinjing Xue, Fei He, Xiaotong Yang, Houru Liu, Kuan Gu, Qianghua Lv, Yonglin Zhou   +7 more
doaj   +1 more source

Synthesis and enzyme-based evaluation of analogues L-tyrosine thiol carboxylic acid inhibitor of metallo-β-lactamase IMP-1

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
The emergence of drug-resistant pathogenic bacteria is occurring due to the global overuse and misuse of β-lactam antibiotics. Infections caused by some bacteria which secrete metallo-β-lactamases (enzymes that inactivate β-lactam antibiotics) are ...
Omid Khalili Arjomandi, Mahboubeh Kavoosi, Hadi Adibi   +2 more
doaj   +1 more source

A Disproportionality Analysis of β‐lactam Antibiotic Related Blood and Lymphatic System Disorders Based on the FDA Adverse Event Reporting System Database

Health Science Reports
Background and Aims β‐lactam antibiotics stand as the most profoundly impactful classes of antibacterial agents worldwide. Their widespread application has raised safety concerns over adverse events (AEs), such as blood and lymphatic system disorders ...
Jing Liu, Min Zhang, Zongwei Tang, Xiaoxiao Wang, Li Mu, Wanyi Chen, Haichi Song   +6 more
doaj   +1 more source

The Mechanisms of Reactions of β-Lactam Antibiotics

, 1987
This chapter explains that penicillin was the first naturally occurring antibiotic to be characterized and used in clinical medicine. It can be seen as the progenitor of the β-lactam family of antibiotics, which are characterized by the possession of the
Michael I. Page, Page, Michael I.
core   +1 more source