Results 81 to 90 of about 61,324 (269)
β-lactam antibiotics, recA mutation and SOS response
, 2015 The claim that β-lactam antibiotics induce the SOS response, allowing E. coli survival in the presence of low antibiotic concentrations, was evaluated. No association between the recA gene and antibiotic survival rate was found.
Zdravko Podlesnek
core +1 more source
Tobramycin pharmacokinetic and pharmacodynamic targets in people with cystic fibrosis
British Journal of Clinical Pharmacology, EarlyView.Intravenous tobramycin is a first‐line treatment for Pseudomonas aeruginosa infection in people with cystic fibrosis (CF). Tobramycin exhibits concentration‐dependent activity; however, excess drug exposure can lead to nephrotoxicity and ototoxicity. While dosing typically targets serum peak (Cmax) and trough (Cmin) concentrations, the area under the ...
Kiera H. Harwood +6 more
wiley +1 more source
Frontiers in Microbiology, 2020 Enterobacter cloacae complex (ECC), one of the most common opportunistic pathogens causing multiple infections in human, is resistant to β-lactam antibiotics mainly due to its highly expressed chromosomal AmpC β-lactamase.
Xianggui Yang +12 more
doaj +1 more source
Probing the Role of Asn 152 in the Class C β-lactamase AmpC
, 2012 AmpC, a class C β-lactamase, is a main cause of antibiotic resistance to cephalosporins in many species of bacteria. The current proposed mechanism of action involves an acyl-intermediate, where the enzyme becomes covalently attached to the drug at ...
Powers, Rachel +4 more
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Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden
ChemFoodChem, EarlyView.ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley +1 more source
mSphere, 2017 Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults.
Sara Marti +7 more
doaj +1 more source
Molecular Targets of β-Lactam-Based Antimicrobials : Beyond the Usual Suspects
, 2014 The common practice in antibacterial drug development has been to rapidly make an attempt to find ever-more stable and broad-spectrum variants for a particular antibiotic, once a drug resistance for that antibiotic is detected.
Monika Konaklieva (16750224)
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Chemistry – A European Journal, EarlyView.Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis +2 more
wiley +1 more source
"Golden Era of Antibiotics" - Coming to an end !!!
SRM Journal of Research in Dental Sciences, 2012 Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini +4 more
doaj
The Visual Predictive Check and Real‐World Data
Clinical Pharmacology &Therapeutics, EarlyView.The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes +2 more
wiley +1 more source