Results 81 to 90 of about 1,201,054 (248)

FtsH Sensitizes Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics by Degrading YpfP, a Lipoteichoic Acid Synthesis Enzyme

, 2021
In the Gram-positive pathogen Staphylococcus aureus, FtsH, a membrane-bound metalloprotease, plays a critical role in bacterial virulence and stress resistance.
Taeok Bae, Kim, Kyeong Kyu, Jeong, Bohyun, Yeo, Won-Sik, Nimat Ullah, Ullah, Nimat, Won-Sik Yeo, Majid Ali Shah, Amjad Ali, Bae, Taeok, Kyeong Kyu Kim, Majid Shah, Kyeong Kim, Shah, Majid Ali, Ali, Amjad, Bohyun Jeong   +15 more
core   +1 more source

Regulation of PBP2x Surface Localization by aliD and clpL Alters β-Lactam Resistance in Pneumococcus

Pathogens
Streptococcus pneumoniae is a leading cause of respiratory infections and is often treated with β-lactam antibiotics despite frequent resistance. The β-lactam resistance is through mutations in penicillin-binding proteins (PBPs), but the impact of PBP ...
Lucas R. G. Crosby, Md Fahim Khan, Larry S. McDaniel, Lance E. Keller   +3 more
doaj   +1 more source

Synergistic Advanced Oxidation and Physicochemical Treatment Strategies for Antibiotic Removal and Resistance Mitigation in Water

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT The presence of antibiotics in water not only causes environmental pollution but also increases the growth of antibiotic‐resistant bacterial genes, which pose serious threats to human beings and other water residents. Large numbers of people are reportedly affected by the resistant bacterial genes, as many broad‐spectrum antibiotics are not ...
Amir Zada, Shohreh Azizi
wiley   +1 more source

The synthesis and structural characterisation of novel 4- and 5- membered nitrogen heterocycles derived from azoacetates [PDF]

, 2009
Azo-drugs are among the earliest fully synthetic chemotherapeutic agents known (Prontosil 1935). However the synthesis and application of phenylazo compounds in the area of medicinal chemistry has largely been restricted to derivatives of primary ...
O'Halloran, Neil
core   +2 more sources

Hypericin enhances β-lactam antibiotics activity by inhibiting sarA expression in methicillin-resistant Staphylococcus aureus

Acta Pharmaceutica Sinica B, 2019
Bacteremia is a life-threating syndrome often caused by methicillin-resistant Staphylococcus aureus (MRSA). Thus, there is an urgent need to develop novel approaches to successfully treat this infection.
Genzhu Wang, Liang Li, Xiukun Wang, Xue Li, Youwen Zhang, Jie Yu, Jiandong Jiang, Xuefu You, Yan Q. Xiong   +8 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

A systematic scoping review of metrics utilized to measure antibiotic consumption in hospital settings

British Journal of Clinical Pharmacology, EarlyView.
Abstract Antimicrobial stewardship (AMS) programs were introduced to promote the judicious use of antimicrobials and to combat antimicrobial resistance. Quantifying antibiotic consumption is an important part of AMS initiatives to achieve these objectives.
Marjan Kandimahforoujaki, Kiplin A. Patanwala, Jan‐Willem C. Alffenaar, Asad E. Patanwala   +3 more
wiley   +1 more source

"Golden Era of Antibiotics" - Coming to an end !!!

SRM Journal of Research in Dental Sciences, 2012
Resistance to antibiotics is increasing at an alarming rate. This is due to superbugs, producing heterogenous groups of enzymes, β-lactamases which inactivate β-lactam antibiotics and others as well.
V Vinodhini, T S Subashini, K S Sridevi Sangeetha, R Shivakumar, Nafeesa Iqbal   +4 more
doaj  

Evaluating a virtual paediatric adverse drug reaction clinic

British Journal of Clinical Pharmacology, EarlyView.
Aims Adverse drug reactions (ADRs) are a common problem in paediatric health care. There is limited access to expertise in the evaluation and management of potential ADRs in children, limiting access to these services and creating delays in assessment and management.
Emily Hauck, Blanca Del Pozzo‐Magana, Michael Rieder   +2 more
wiley   +1 more source

Bacterial Lysis through Interference with Peptidoglycan Synthesis Increases Biofilm Formation by Nontypeable Haemophilus influenzae

mSphere, 2017
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that mainly causes otitis media in children and community-acquired pneumonia or exacerbations of chronic obstructive pulmonary disease in adults.
Sara Marti, Carmen Puig, Alexandra Merlos, Miguel Viñas, Marien I. de Jonge, Josefina Liñares, Carmen Ardanuy, Jeroen D. Langereis   +7 more
doaj   +1 more source