Results 101 to 110 of about 1,201,054 (248)

The Effect of Dicloxacillin Administration on Pharmacokinetics of Narrow Therapeutic Window Drugs: Phenytoin and Warfarin

Clinical Pharmacology &Therapeutics, EarlyView.
Dicloxacillin is a penicillinase‐resistant beta‐lactam antibiotic and potent activator of the Pregnane X receptor (PXR), known to induce CYP2C9, CYP2C19, and CYP3A4 activity. Clinical data suggest it reduces anticoagulation in warfarin‐treated patients and increases the risk of thromboembolic events.
Chanan Shaul, Waseem Mujahed, Ibrahim Idries, Maor Wanounou, Meir Bialer, Yoseph Caraco   +5 more
wiley   +1 more source

One-step degradation of 4 classes of β-lactam using β-lactamase enzyme cocktail

Scientific Reports
Antibiotics, particularly β-lactams, are emerging environmental contaminants that induce antibiotic-resistant bacteria or genes, which threaten public health. Enzymatic degradation is an environmentally friendly approach to reducing residual antibiotics;
Jiafu Lin, Tiantian Wang, Yaliang Zhou, Tao Cheng, Haisha Liu, Xueke Chen, Wan Luo, Qiyue Liu, Yiwen Chu, Xinrong Wang, Feng Xie, Jingzhou Sha, Tao Song   +12 more
doaj   +1 more source

The Mechanism of Emodin Against Methicillin-Resistant Staphylococcus aureus Infection and Research on Synergistic Antibiotics

Life
Methicillin-resistant Staphylococcus aureus (MRSA) poses a significant clinical challenge due to its multidrug resistance, particularly to β-lactam antibiotics.
Chenliang Chu, Liang Qin, Huayong Peng, Tao Kuang, Yongshi Li, Xin Wang, Fenglan Liang, Ping Gao, Xiaoxiong Wang, Deyun Ma   +9 more
doaj   +1 more source

Decreased affinity of a penicillin-binding protein for β-lactam antibiotics in a clinical isolate ofStaphylococcus aureusresistant to methicillin [PDF]

FEMS Microbiology Letters, 1981
Michael V. Hayes, Nigel A.C. Curtis, Anne W. Wyke, J. Barrie Ward   +3 more
openaire   +1 more source

Molecular targets of β-Lactam-based antimicrobials : Beyond the usual suspects : Beyond the usual suspects

, 2018
The common practice in antibacterial drug development has been to rapidly make an attempt to find ever-more stable and broad-spectrum variants for a particular antibiotic, once a drug resistance for that antibiotic is detected.
Monika Konaklieva (16750224)
core   +1 more source

Uptake of dipeptide and β-lactam antibiotics by the basolateral membrane vesicles prepared from rat kidney [PDF]

, 2002
The transport of dipeptides and β-lactam antibiotics across the rat renal basolateral membrane was examined. The initial uptake of glycylsarcosine and cefadroxil by rat renal basolateral membrane vesicles was inhibited by the presence of all the di- and ...
Michiya Kobayashi, Ogawa, Toru, Miyazaki, Katsumi, Kobayashi, Michiya, Mitsuru Sugawara, Katsumi Miyazaki, Toru Ogawa, Sugawara, Mitsuru   +7 more
core   +1 more source

Incidence and impact of respiratory tract infections on outcomes in patients with status epilepticus: A 20‐year longitudinal observation

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to identify the incidence of respiratory tract infections (RTIs) in a large cohort of adult patients with status epilepticus (SE) and to characterize their associations with clinical features and outcome determinants.
Sebastian Berger, Sira M. Baumann, Urs Fisch, Lisa Hert, Pascale Grzonka, Sabina Hunziker, Stephan Rüegg, Sarah Tschudin‐Sutter, Raoul Sutter   +8 more
wiley   +1 more source

New β-Lactam/β-Lactamase Inhibitor Combination Antibiotics

Pathogens
The growing problem of infections due to pathogens with antimicrobial resistance, especially Gram-negative bacteria, has led to the development of new β-lactam/β-lactamase inhibitor combination antibiotics.
Maria Sargianou, Panagiotis Stathopoulos, Christos Vrysis, Iva D. Tzvetanova, Matthew E. Falagas   +4 more
doaj   +1 more source

In Vitro Characterization of Technological and Health‐Promoting Properties of Enterocin Producing Lactic Acid Bacteria From Camel Milk and Its Suitability as a Dairy Starter

Food Chemistry International, EarlyView.
Enterocin‐producing Enterococcus faecium RSCUDR7 from camel milk exhibited strong probiotic and antimicrobial properties, along with stability in skim milk. Its suitability as a safe and effective dairy starter highlights its potential for developing functional probiotic dairy products.
Rahul Singhal, Kamalesh Kumar Meena, Manvik Joshi, Lokesh Gupta, Sunil Meena   +4 more
wiley   +1 more source

Multiple Roles of Cu(II) in Catalyzing Hydrolysis and Oxidation of β‑Lactam Antibiotics

, 2016
The widely used β-lactam antibiotics such as penicillins and cephalosporins are known to be susceptible to CuII-catalyzed hydrolysis at their four-membered β-lactam ring.
Jiabin Chen (1624723), Peizhe Sun (1345995), Yalei Zhang (478592), Ching-Hua Huang (1345989)   +3 more
core   +1 more source