Results 91 to 100 of about 86,850 (260)

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

β-Lactam Resistance in Staphylococcus Species Isolated from Students

, 2016
β-lactam antibiotics have been a cornerstone in the treatment of Staphylococcus aureus infections for decades, but increasing resistance rates threaten to reduce their reliability. Because β-lactam drugs remain one of the major classes of antibiotics, it
Grund, Laurie
core  

PBP5, PBP6 and DacD play different roles in intrinsic β-lactam resistance of Escherichia coli

, 2011
Escherichia coli PBP5, PBP6 and DacD, encoded by dacA, dacC and dacD, respectively, share substantial amino acid identity and together constitute ~50 % of the total penicillin-binding proteins of E. coli.
Akash Kumar, Chiranjit Chowdhury, Anindya S. Ghosh, Mouparna Dutta, Sujoy Kumar Sarkar   +4 more
core   +1 more source

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Characterisation of a novel plasmid-mediated β-lactamase and its contribution to β-lactam resistance inPseudomonas aeruginosa [PDF]

FEMS Microbiology Letters, 1983
I.N. Simpson, S.J. Plested, Miroslava J. Budin-Jones, Jeanette Lees, R.W. Hedges, G.A. Jacoby   +5 more
openaire   +1 more source

Characterization of acquired β-lactamases in Pseudomonas aeruginosa and quantification of their contributions to resistance

Microbiology Spectrum
Pseudomonas aeruginosa is a highly problematic opportunistic pathogen that causes a range of different infections. Infections are commonly treated with β-lactam antibiotics, including cephalosporins, monobactams, penicillins, and carbapenems, with ...
Karl A. Glen, Iain L. Lamont
doaj   +1 more source

Decreased affinity of a penicillin-binding protein for β-lactam antibiotics in a clinical isolate ofStaphylococcus aureusresistant to methicillin [PDF]

FEMS Microbiology Letters, 1981
Michael V. Hayes, Nigel A.C. Curtis, Anne W. Wyke, J. Barrie Ward   +3 more
openaire   +1 more source

Molecular evolution of bacterial β-lactam resistance

, 1996
Background: Two groups of penicillin-destroying enzymes, the class A and class C β-lactamases, may have evolved from bacterial transpeptidases that transfer x-d-Ala-d-Ala peptides to the growing peptidoglycan during cell wall synthesis.
Moews, Paul C., Knox, James R., Frere, Jean-Marie   +2 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source