Results 101 to 110 of about 52,668 (245)

Cooperative resistance varies among β-lactamases in E. coli, with some enabling cross-protection and sustained extracellular activity

Communications Biology
β-lactamases confer bacteria resistance to β-lactam antibiotics, and interestingly, this protective effect can extend to neighboring susceptible cells. However, knowledge of this cooperative resistance remains limited.
Qinqin Wang, Shaodong Wei, Jonas Stenløkke Madsen   +2 more
doaj   +1 more source

Prevalence of ambler class a extended-spectrum- β -lactamases (ESBLS) among Uropathogenic Escherichia coli strains isolated from Rasht city, Iran

Bioscience Journal, 2017
Extended spectrum β-lactamases (ESBLs), a group of bacterial enzymes which are the major cause of resistance to penicillins, broad spectrum cephalosporins and monobactams, are found among the member of Enterobacteriaceae. The class A ESBLs are mainly encoded by the plasmid mediated blaSHV, blaTEM and blaCTX-M genes. In this study, prevalence of Ambler
Zamani, Hojjatolah, Salehzadeh, Ali, Zarrin, Seddigheh   +2 more
openaire   +5 more sources

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) 2025 guidelines for surgical antimicrobial prophylaxis in dogs and cats

Journal of Small Animal Practice, EarlyView.
Surgical antimicrobial prophylaxis involves the administration of antimicrobials to reduce the risk of a surgical site infection and represents a significant proportion of all antimicrobial use in cats and dogs. This evidence‐based, European Network for Optimization of Veterinary Antimicrobial Therapy guideline provides recommendations for both peri ...
F. Allerton, T. M. Sørensen, K. Scahill, J. E. Ruperez, F. Swinbourne, D. R. Verwilghen, M. C. Nolff, F. Foroutan, S. J. Baines, A. Vilen, L. Pelligand, E. M. Broens, P. L. Toutain, M. L. Brennan, T. Mooney, S. Clarke, J. E. Miles, J. L. Granick, Y. Winsborg, L. R. Jessen, J. S. Weese, on behalf of the European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines and the ESCMID Study Group for Veterinary Microbiology (ESGVM)   +21 more
wiley   +1 more source

A study on sensitivity of Flavobacterium to antibiotics isolated in clinical ICU and the state of producing β-Lactamase

Huli yanjiu, 2004
Objective: to determine both β-Lactamase and extended-spectrum β-Lactamase （ESBLs） produced by Flavobacterium isolated from ICU in affiliated southwest hospital of the third military medical university, and the sensitivity to antibiotics commonly used ...
罗羽, 王仙园, 夏培元, 殷春红
doaj  

Pharmacokinetics of Long‐Acting Ampicillin and Its Impact on the Gut Microbiome and Resistome in Rhesus Macaques (Macaca mulatta)

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Injectable antimicrobials with documented prolonged dosing intervals (> 48 h) for use in rhesus macaques are sparse. The objective of our study was to assess the pharmacokinetics, urine excretion, and effects on gut microbiome and resistome of intramuscular administered long‐acting formulation of ampicillin (Albipen LA) in macaques.
Annemiek Maaskant, Ingeborg M. van Geijlswijk, Mathias Devreese, Marc Cherlet, Leo F. van Geest, Jaap A. Wagenaar, Jan A. M. Langermans, Aldert L. Zomer, Jaco Bakker, Ronette Gehring   +9 more
wiley   +1 more source

Proposed Meropenem Breakpoints for Interpretation of Antimicrobial Susceptibility Testing of Bacteria Isolated From Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Meropenem is a carbapenem antibiotic used infrequently in veterinary medicine. However, antimicrobial susceptibility testing standards are needed to monitor for resistance caused by carbapenem resistant Enterobacterales (CRE). The Clinical and Laboratory Standards Institute (CLSI) does not have veterinary‐specific carbapenem breakpoints for ...
Mark G. Papich, Marilyn N. Martinez
wiley   +1 more source

Therapeutic Strategies and Clinical Outcomes of Infections Following Anterior Cruciate Ligament Reconstruction: A Narrative Review

Orthopaedic Surgery, EarlyView.
ACL reconstruction‐associated infections threaten graft integrity and joint function. This review summarizes patient‐related risk factors, approaches, and treatment strategies, with emphasis on early recognition and preventive measures such as vancomycin presoaking.
Shaoli Zhang, Jue Gong
wiley   +1 more source

Analysis of the plasmid content of three β-lactamase-producingNeisseria gonorrhoeaestrains [PDF]

FEMS Microbiology Letters, 1982
Olivier Fayet, Yvette Froment, Jean-Claude Piffaretti   +2 more
openaire   +1 more source

Analysis of OmpC-β-lactamase hybrid proteins: OmpC appears not to contain discrete localization signals [PDF]

FEMS Microbiology Letters, 1990
Hannu T. Saarilahti, E. Tapio Palva
openaire   +1 more source