Results 21 to 30 of about 14,756 (172)
Inhibition of β-lactamase function by de novo designed peptide.
PLoS ONE, 2023 Antimicrobial resistance is a great public health concern that is now described as a "silent pandemic". The global burden of antimicrobial resistance requires new antibacterial treatments, especially for the most challenging multidrug-resistant bacteria.
Arunima Mishra +4 more
doaj +1 more source
mBio, 2022 β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that differ by an ...
Philip Hinchliffe +10 more
doaj +1 more source
Structures of SHV-1 β-lactamase with penem and penam sulfone inhibitors that form cyclic intermediates stabilized by carbonyl conjugation. [PDF]
PLoS ONE, 2012 Bacterial β-lactamase enzymes are in large part responsible for the decreased ability of β-lactam antibiotics to combat infections. The inability to overcome β-lactamase mediated resistance spurred the development of inhibitors with penems and penam ...
Wei Ke +6 more
doaj +1 more source
Pharmacokinetics of Non-β-Lactam β-Lactamase Inhibitors
Antibiotics, 2021 The growing emergence of drug-resistant bacterial strains is an issue to treat severe infections, and many efforts have identified new pharmacological agents.
Giacomo Luci +3 more
doaj +1 more source
In vitro and in vivo Inhibitory Activity of NADPH Against the AmpC BER Class C β-Lactamase
Frontiers in Cellular and Infection Microbiology, 2018 β-Lactamase-mediated resistance to β-lactam antibiotics has been significantly threatening the efficacy of these clinically important antibacterial drugs.
Jung-Hyun Na +9 more
doaj +1 more source
Novel β-lactamase inhibitors: a therapeutic hope against the scourge of multidrug resistance
Frontiers in Microbiology, 2013 The increasing incidence and prevalence of multidrug resistance (MDR) among contemporary Gram-negative bacteria represents a significant threat to human health.
Richard eWatkins +3 more
doaj +1 more source
Iranian Journal of Microbiology, 2022 Background and Objectives: Escherichia coli (E. coli) is an important member of Enterobacteriaceae family involved in severe infections. The increased rate of resistance towards different classes of antibiotics limits their treatment options. The aim of
Ashraf Ahmed Kadry +2 more
doaj +1 more source
Antimicrobial Resistance and Infection Control, 2016 Background Bacteria belonging to the Burkholderia cepacia complex (Bcc) are an important cause of chronic respiratory tract infections in cystic fibrosis patients.
Annelien Everaert, Tom Coenye
doaj +1 more source
Frontiers in Microbiology, 2021 Objectives: Carbapenemase-producing organisms (CPOs) are associated with high mortality rates. The recent development of β-lactamase inhibitors (BLIs) has made it possible to control CPO infections safely and effectively with β-lactams (BLs).
Yanfang Feng +8 more
doaj +1 more source
Periodontology 2000, EarlyView., 2023 Abstract This narrative review summarizes the collective knowledge on periodontal microbiology, through a historical timeline that highlights the European contribution in the global field. The etiological concepts on periodontal disease culminate to the ecological plaque hypothesis and its dysbiosis‐centered interpretation.
Georgios N. Belibasakis +5 more
wiley +1 more source