Results 81 to 90 of about 1,672,197 (320)

The Role of Hydrophobic Nodes in the Dynamics of Class A β-Lactamases

Frontiers in Microbiology, 2021
Class A β-lactamases are known for being able to rapidly gain broad spectrum catalytic efficiency against most β-lactamase inhibitor combinations as a result of elusively minor point mutations.
Edgar Olehnovics, Junqi Yin, Adrià Pérez, Gianni De Fabritiis, Gianni De Fabritiis, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Robert A. Bonomo, Debsindhu Bhowmik, Shozeb Haider   +13 more
doaj   +1 more source

Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype [PDF]

, 2017
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs).
Bordignon, Valentina, Cavallo, Ilaria, Cilli, Laura, De Santis, Alessandra, Di Domenico, Enea Gino, Di Salvo, Fabiola, Ensoli, Fabrizio, Farulla, Ilaria, Gallo, Maria Teresa, La Parola, Ilaria Lesnoni, Pimpinelli, Fulvia, Pontone, Martina, Prignano, Grazia, Sperduti, Isabella, Toma, Luigi, Vespaziani, Matteo   +15 more
core   +2 more sources

Bicyclic Boronate VNRX-5133 Inhibits Metallo- and Serine-β-Lactamases

Journal of Medicinal Chemistry, 2019
The bicyclic boronate VNRX-5133 (taniborbactam) is a new type of β-lactamase inhibitor in clinical development. We report that VNRX-5133 inhibits serine-β-lactamases (SBLs) and some clinically important metallo-β-lactamases (MBLs), including NDM-1 and ...
Alen Krajnc, J. Brem, P. Hinchliffe, Karina Calvopiña, Tharindi D Panduwawala, P. Lang, J. Kamps, J. Tyrrell, Emma Widlake, B. G. Saward, T. Walsh, J. Spencer, C. Schofield   +12 more
semanticscholar   +1 more source

Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Although prophylactic broad‐spectrum antibiotics can reduce postoperative complications after pancreaticoduodenectomy (PD), the optimal regimen remains uncertain. This study evaluated the impact of prophylactic cefepime (CFPM) on surgical site infection (SSI) and severe morbidity after PD with preoperative biliary drainage.
Genki Watanabe, Akihiro Murata, Yu Kasamatsu, Atsushi Ishihara, Daisuke Nagashima, Tetsuzo Tashima, Shintaro Kodai, Akishige Kanazawa, Sadatoshi Shimizu   +8 more
wiley   +1 more source

Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens [PDF]

, 2019
The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such as Pseudomonas aeruginosa and Staphylococcus aureus, and microorganisms that are typically not associated with worse clinical ...
Coenye, Tom, Crabbé, Aurélie, Tavernier, Sarah, Vandeplassche, Eva   +3 more
core   +1 more source

A rational strategy to optimize photodrugs by Molecular Dynamics simulations for killing drug‐resistant Gram‐negative bacteria

AIChE Journal, EarlyView.
Abstract Antimicrobial resistance has become a major threat to human health, particularly for Gram‐negative bacteria such as Acinetobacter baumannii and Klebsiella pneumoniae. Disruption of membrane integrity is regarded as a promising antimicrobial strategy that does not induce distinct drug resistance, while increasing the internalization of drug ...
Lei Hao, Yeonho Song, Cheng Zhang, Yumei Wang, Haoying Ge, Wen Sun, Jingyun Wang, Jun Soo Kim, Xiaojun Peng, Juyoung Yoon, Haidong Li   +10 more
wiley   +1 more source

Expanding the β‐Lactamase Family in the Human Microbiome

Advanced Science
β‐lactams, the most common antibiotics globally, have resistance primarily determined by β‐lactamases. Human microbiota and β‐lactams influence mutually; however, β‐lactamase variety and abundance in the human microbiome remain partially understood. This
Baolei Jia, Ju Hye Baek, Jae Kyeong Lee, Ying Sun, Kyung Hyun Kim, Ji Young Jung, Che Ok Jeon   +6 more
doaj   +1 more source

Classification of Beta-lactamases and penicillin binding proteins using ligand-centric network models. [PDF]

PLoS ONE, 2015
β-lactamase mediated antibiotic resistance is an important health issue and the discovery of new β-lactam type antibiotics or β-lactamase inhibitors is an area of intense research.
Hakime Öztürk, Elif Ozkirimli, Arzucan Özgür   +2 more
doaj   +1 more source

Antimicrobial Peptides Designed against the Ω-Loop of Class A β-Lactamases to Potentiate the Efficacy of β-Lactam Antibiotics

Antibiotics, 2023
Class A serine β-lactamases (SBLs) have a conserved non-active site structural domain called the omega loop (Ω-loop), in which a glutamic acid residue is believed to be directly involved in the hydrolysis of β-lactam antibiotics by providing a water ...
Sarmistha Biswal, Karina Caetano, Diamond Jain, Anusha Sarrila, Tulika Munshi, Rachael Dickman, Alethea B. Tabor, Surya Narayan Rath, Sanjib Bhakta, Anindya S. Ghosh   +9 more
doaj   +1 more source

Machine Learning‐Augmented Loop‐Mediated Isothermal Amplification‐Enabled Point‐of‐Care for Mpox‐Specific Detection

Advanced Intelligent Systems, EarlyView.
A low‐cost, portable point‐of‐care platform for rapid Mpox detection using loop‐mediated isothermal amplification is reported. The device integrates fluorescence readout and mobile monitoring. A machine‐learning model analyzes temperature data and correlates thermal changes with DNA concentration, enabling sensitive and reliable molecular diagnosis in ...
Nazente Atceken, Ahmed Choukri Abdullah, Olgac Ozarslan, Ziya Yıldız, Savas Tasoglu   +4 more
wiley   +1 more source