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Drug Discovery in the Field of β-Lactams: An Academic Perspective [PDF]

Antibiotics
β-Lactams are the most widely prescribed class of antibiotics that inhibit penicillin-binding proteins (PBPs), particularly transpeptidases that function in peptidoglycan synthesis.
Lian M. C. Jacobs, Patrick Consol, Yu Chen   +2 more
doaj   +3 more sources

β-Lactams from the Ocean

Marine Drugs, 2023
The title of this essay is as much a question as it is a statement. The discovery of the β-lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if not exclusively) secondary metabolites of terrestrial fungi and bacteria ...
Jed F. Fisher, Shahriar Mobashery
doaj   +2 more sources

Penicillin‐binding protein PBP2a provides variable levels of protection toward different β‐lactams in Staphylococcus aureus RN4220

MicrobiologyOpen, 2020
Methicillin‐resistant Staphylococcus aureus (MRSA) is resistant to most β‐lactams due to the expression of an extra penicillin‐binding protein, PBP2a, with low β‐lactam affinity.
Marte Ekeland Fergestad, Gro Anita Stamsås, Danae Morales Angeles, Zhian Salehian, Yngvild Wasteson, Morten Kjos   +5 more
doaj   +2 more sources

Diclofenac Resensitizes Methicillin‐Resistant Staphylococcus aureus to β‐Lactams and Prevents Implant Infections

Advanced Science, 2021
Implant infections caused by methicillin‐resistant Staphylococcus aureus (MRSA) can cause major complications during the perioperative period. Diclofenac, one of the most widely used nonsteroidal anti‐inflammatory drugs, is often used to relieve pain and
Shutao Zhang, Xinhua Qu, Haozheng Tang, You Wang, Hongtao Yang, Weien Yuan, Bing Yue   +6 more
doaj   +2 more sources

Mycobacterium abscessus and β-Lactams: Emerging Insights and Potential Opportunities

Frontiers in Microbiology, 2018
β-lactams, the most widely used class of antibiotics, are well-tolerated, and their molecular mechanisms of action against many bacteria are well-documented.
Elizabeth Story-Roller, Emily C. Maggioncalda, Keira A. Cohen, Gyanu Lamichhane   +3 more
doaj   +2 more sources

High serum β-lactams specific/total IgE ratio is associated with immediate reactions to β-lactams antibiotics. [PDF]

PLoS ONE, 2015
Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available.
Alessandra Vultaggio, Gianni Virgili, Francesco Gaeta, Antonino Romano, Enrico Maggi, Andrea Matucci   +5 more
doaj   +2 more sources

Penicillin Binding Proteins and β-Lactamases of Mycobacterium tuberculosis: Reexamination of the Historical Paradigm

mSphere, 2022
Penicillin binding proteins (PBPs) have been extensively studied due to their importance to the physiology of bacterial cell wall peptidoglycan and as targets of the most widely used class of antibiotics, the β-lactams. The existing paradigm asserts that
Gaurav Kumar, Christos Galanis, Hunter R. Batchelder, Craig A. Townsend, Gyanu Lamichhane   +4 more
doaj   +1 more source

Hazard assessment of beta-lactams: Integrating in silico and QSTR approaches with in vivo zebrafish embryo toxicity testing

Ecotoxicology and Environmental Safety, 2022
Antibiotics have emerged as a well-known representative of pharmaceuticals and personal care products (PPCPs) by causing public health and environmental problems due to their potential toxicity.
Ying Han, Yuanyuan Ma, Bo Chen, Jingpu Zhang, Changqin Hu   +4 more
doaj   +1 more source

Giant linear plasmids of β-lactam antibiotic producing Streptomyces [PDF]

FEMS Microbiology Letters, 1995
A survey of the total cellular DNA from five β-lactam antibiotic-producing Streptomyces spp. by pulsed field gel electrophoresis was conducted to investigate the presence of linear plasmids. Streptomyces clavuligerus NRRL 3585 contained two giant linear plasmids of 120 and 430 kb, in addition to the well-characterized 11.7 kb linear plasmid ...
Donald J. Netolitzky, Xiaoning Wu, Susan E. Jensen, Kenneth L. Roy   +3 more
openaire   +1 more source

A review of penicillin binding protein and group A Streptococcus with reduced-β-lactam susceptibility

Frontiers in Cellular and Infection Microbiology, 2023
With the widespread use of antibiotics, antimicrobial resistance (AMR) has become a global problem that endangers public health. Despite the global high prevalence of group A Streptococcus (GAS) infections and the global widespread use of β-lactams, β ...
Dingle Yu, Danchun Guo, Yuejie Zheng, Yonghong Yang, Yonghong Yang   +4 more
doaj   +1 more source