Results 51 to 60 of about 1,666,677 (276)
Antimicrobial Agents and Chemotherapy, 2018 Penicillin-binding proteins (PBPs) are the high-affinity target sites of all β-lactam antibiotics in bacteria. It is well known that each β-lactam covalently binds to and thereby inactivates different PBPs with various affinities.
Dhruvitkumar S. Sutaria +8 more
semanticscholar +1 more source
Commonly prescribed β-lactam antibiotics induce C. trachomatis persistence/stress in culture at physiologically relevant concentrations [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Chlamydia trachomatis, the most common bacterial sexually transmitted disease agent worldwide, enters a viable, non-dividing and non-infectious state (historically termed persistence and more recently referred to as the chlamydial stress response) when exposed to penicillin G in culture.
Kintner, Jennifer +4 more
openaire +4 more sources
Angewandte Chemie, EarlyView.Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang +6 more
wiley +2 more sources
Repurposing β-Lactams for the Treatment of Mycobacterium kansasii Infections: An In Vitro Study
Antibiotics, 2023 Mycobacterium kansasii (Mkn) causes tuberculosis-like lung infection in both immunocompetent and immunocompromised patients. Current standard therapy against Mkn infection is lengthy and difficult to adhere to.
Lara Muñoz-Muñoz +2 more
doaj +1 more source
Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases [PDF]
Journal of Antimicrobial Chemotherapy, 2015 OP0595 is a diazabicyclooctane that (i) acts as a PBP2-active antibacterial, (ii) inhibits Class A and C β-lactamases and (iii), like mecillinam, gives β-lactamase-independent potentiation of β-lactams targeting other PBPs. We tested its behaviour against β-lactam-resistant Enterobacteriaceae and non-fermenters.Organisms were UK clinical isolates; MICs
Livermore, David M. +3 more
openaire +4 more sources
Lipid II overproduction allows direct assay of transpeptidase inhibition by β-lactams
Nature Chemical Biology, 2017 Peptidoglycan is an essential crosslinked polymer that surrounds bacteria and protects them from osmotic lysis. Beta-lactam antibiotics target the final stages of peptidoglycan biosynthesis by inhibiting the transpeptidases that crosslink glycan strands ...
Yuan Qiao +6 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Fast‐acting hydrogel seals bleeding wounds as the illustrated injectable, pH‐responsive network rapidly gels in situ to stop hemorrhage, adhere strongly to wet tissue, and release antibiotics in a controlled, pH‐dependent manner. The material withstands high pressures, shows excellent biocompatibility, and degrades safely, offering a versatile platform
Arvind K. Singh Chandel +5 more
wiley +1 more source
An update on the synthesis and reactivity of spiro-fused β-lactams
Arkivoc, 2019 Beta-Lactam ring-containing compounds play a pivotal role in drug design and synthetic chemistry. Spirocyclic beta-lactams, representing an important beta-lactam subclass, have recently attracted considerable interest with respect to new synthetic methodologies and pharmacological applications.
Dao Thi, Hang, D'hooghe, Matthias
openaire +2 more sources
The barrier function of the outer membrane ofPseudomonas maltophiliain the diffusion of saccharides and β-lactam antibiotics [PDF]
FEMS Microbiology Letters, 1989 This paper reports that the efficiency of solute diffusion through the outer membrane of Pseudomonas maltophilia is roughly 3 to 5% of that of Escherichia coli. This is despite the fact that the outer membrane pore(s) is only a little smaller than that of E. coli. These results suggest that P. maltophilia has a low copy number of porin(s).
E, Yamazaki, J, Ishii, K, Sato, T, Nakae
openaire +2 more sources
Have we realized the full potential of β‐lactams for treating drug‐resistant TB?
IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2018 β‐lactams are the most widely used antibiotics and are effective against a spectrum of pathogenic bacteria. Here, we focus on the state‐of‐the‐art understanding of the molecular underpinnings that determine the overall efficacy of β‐lactams against TB ...
Elizabeth Story-Roller, G. Lamichhane
semanticscholar +1 more source