Results 71 to 80 of about 900,428 (178)

β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice.

Food & Function
Ageing is defined as the degeneration of physiological functions in numerous tissues and organs of an organism, which occurs with age. As we age, the gut undergoes a series of changes and weaknesses that may contribute to overall ageing.
Yanrou Gu, Li-da Gao, Jiaming He, Man Luo, Mei Hu, Yu-Xian Lin, Jianxin Li, Tong-Yao Hou, Jianmin Si, Yingcong Yu   +9 more
semanticscholar   +1 more source

Fermented Porcine Placenta and Its Dipeptides Modulate Cellular Senescence in Human Keratinocytes

Current Issues in Molecular Biology
Skin aging is primarily driven by oxidative stress, mitochondrial dysfunction, and cell cycle dysregulation. This study investigated the anti-senescence effects of fermented porcine placenta (FPP) and its dipeptides, leucine–glycine (LG) and proline ...
Yea Jung Choi, Minseo Kang, Mu Hyun Jin, Jongbae Kim, Won Kyung Lee, Seok-Seon Roh, Ki Sung Kang, Gwi Seo Hwang, Sangki Park, Sullim Lee   +9 more
doaj   +1 more source

MyD88‐Family Adaptors: Compartmentalised Signalling and Non‐Immune Functions

Immunology, EarlyView.
MyD88‐family adaptors coordinate receptor‐ and compartment‐specific innate immune signalling across plasma membrane and endosomal pathways. At the plasma membrane, TIRAP/MAL supports MyD88‐dependent signalling downstream of TLR2 and TLR4, whereas endosomal TLR7, TLR8 and TLR9 recruit MyD88 directly.
Seshu Vardhan Pothabathula, Saurabh Mishra, Pugazhendhi Kannan, Annette Bellar, Amy Attaway, Nicole Welch, Srinivasan Dasarathy   +6 more
wiley   +1 more source

Fortification Technology and Quality Evaluation of β-Nicotinamide Mononucleotide in Fermented Coix Seed

Shipin gongye ke-ji
The aim of this study was to develop a fermented food rich in β-nicotinamide mononucleotide (β-NMN). The influence of fermentation strain, fermentation time, and addition of B-group vitamins on the β-NMN content of fermented Coix (Coix lacryma-jobi) seed
Caihua LIU, Riying HUANG, Xinyun MAI, Rongfeng LI, Qiuliu LIU, Guojiao WANG, Lingling LÜ   +6 more
doaj   +1 more source

Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men

BMC Geriatrics, 2023
Background Age-related hearing loss (ARHL) is a common phenomenon observed during aging. On the other hand, the decrease in Nicotinamide adenine dinucleotide (NAD +) levels is reported to be closely related to the age-related declines in physiological ...
Yoshiko Nakagawa-Nagahama, Masaki Igarashi, Masaomi Miura, Kosuke Kashiwabara, Keisuke Yaku, Yuichiro Fukamizu, Toshiya Sato, Takanobu Sakurai, Takashi Nakagawa, Takashi Kadowaki, Toshimasa Yamauchi   +10 more
doaj   +1 more source

Novel Amino Acid Changes Increase Phosphoenolpyruvate Carboxylase Output in planta

Plant, Cell &Environment, EarlyView.
ABSTRACT Characterization of previously reported Arabidopsis mutants with increased aluminum (Al) resistance (alr) resulting from greater release of Al‐chelating malate identified three unique amino acid substitutions that each impacts PHOSPHOENOLPYRUVATE CARBOXYLASE 1, a key anaplerotic carbon fixation enzyme.
Jinrui Sheng, Kevin Frausto, Sarah Haesaerts, Taylor J. Meyer, Maruša Prolič‐Kalinšek, Seán E. O'Leary, Remy Loris, Paul B. Larsen   +7 more
wiley   +1 more source

Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells [PDF]

, 2017
Objective: Augmenting nicotinamide adenine dinucleotide (NAD+) availability may protect skeletal muscle from age-related metabolic decline. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) appear
Migaud, Marie E., Lucy A. Oakey, Rachel S. Fletcher, Carles Canto, Brenner, C, Migaud, ME, Oakey, Lucy A, Gabriella Da Silva Xavier, Joanna Ratajczak, Craig L. Doig, Philp, A, Lavery, Gareth G., Canto, Carles, Da Silva Xavier, Gabriella; id_orcid, Canto, C, Garten, Antje, Oakey, Lucy A., Elhassan, Yasir S., Lavery, GG, Yasir S. Elhassan, Elhassan, Yasir S; id_orcid, Elhassan, YS, Ratajczak, Joanna, Callingham, Rebecca, Fletcher, RS, Redpath, P, Antje Garten, Garten, A, Xavier, Gabriella Da Silva, Da Silva Xavier, G, Oakey, LA, Doig, Craig L., Fletcher, Rachel S., Andrew Philp, Gareth G. Lavery, Migaud, Marie E, Brenner, Charles, Charles Brenner, Marie E. Migaud, Ratajczak, J, Callingham, R, Rebecca Callingham, Philp, Andrew, Doig, CL, Doig, Craig L, Redpath, Philip, Lavery, Gareth G, Philip Redpath, Fletcher, Rachel S   +48 more
core   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source

NAD replenishment restores mitochondrial function and thermogenesis in the brown adipose tissue of mice with obesity

The Journal of Physiology, EarlyView.
Abstract figure legend A high‐fat diet (HFD) induces brown adipose tissue (BAT) whitening, mitochondrial dysfunction (damaged cristae, fragmentation), reduced NAD+ levels and impaired thermogenesis, leading to lower energy expenditure and metabolic inflexibility.
Renata R. Braga, Matheus B. Rocha, Ana P. Morelli, Raul G. da Costa, Marcelo A. S. Mori, Adelino S. R. da Silva, José R. Pauli, Dennys E. Cintra, Eduardo R. Ropelle   +8 more
wiley   +1 more source

Functional characterisation of three human nicotinamide mononucleotide adenylyltransferases [PDF]

, 2008
Nicotinamide adenine dinucleotide, NAD, is an essential redox factor in many, primarily catabolic, hydrogen transfer reactions. While the redox reactions are not accompanied by a net loss of the pyridine nucleotides, NAD+ is actively degraded in a ...
Lau, Corinna
core   +1 more source