Results 81 to 90 of about 900,428 (178)

Fermentation Process and Functional Properties of β-Nicotinamide Mononucleotide-enriched Fruit-Vegetable Jiaosu

Shipin gongye ke-ji
In order to study the β-nicotinamide mononucleotide-enriched fruit-vegetable Jiaosu and evaluate its bioactivity, cucumber powder, broccoli powder, banana powder and apple powder were used as substrates, and the process parameters were optimized by multi-
Tao JI, Xuanyi CHEN, Ziyang CHENG, Yonghai RUAN, Senhe QIAN, Zhou WANG   +5 more
doaj   +1 more source

Targeting the NAD+ salvage pathway suppresses APC mutation-driven colorectal cancer growth and Wnt/β-catenin signaling via increasing Axin level

Cell Communication and Signaling, 2020
Background The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood.
Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen, Shu Zheng   +8 more
doaj   +1 more source

P7C3 Compounds as Targeted Mitochondrial Therapeutics for Brain Disorders

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
P7C3 activates NAMPT, the rate‐limiting enzyme in the NAD+ salvage pathway, elevating NAD+ levels in neurons. This engages SIRT1‐dependent nuclear signaling and SIRT3‐dependent mitochondrial regulation, enhancing mitochondrial quality control, reducing oxidative stress, and promoting neuronal survival.
Yajing Chen, Xiaohuan Du, Fang Li, Shuwei Yuan, Wenjing Wang, Zengyan Zhu, Mei Wang, Chao Gu   +7 more
wiley   +1 more source

Pre-emptive Short-term Nicotinamide Mononucleotide Treatment in a Mouse Model of Diabetic Nephropathy

, 2021
BACKGROUND: The activation of NAD(+)-dependent deacetylase, Sirt1, by the administration of nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases.
Yasuda, Itaru, Hirobumi Tokuyama, Shu Wakino, Ei Kusahana, Takashi Ono, Hiroshi Itoh, Kusahana, Ei, Takeshi Kanda, Muraoka, Hirokazu, Tokuyama, Hirobumi, Kanda, Takeshi, Yusuke Sakamaki, Itoh, Hiroshi, Takahisa Kawaguchi, Sakamaki, Yusuke, Wakino, Shu, Ono, Takashi, Kazuhiro Hasegawa, Hirokazu Muraoka, Kawaguchi, Takahisa, Itaru Yasuda, Hasegawa, Kazuhiro   +21 more
core   +1 more source

Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies

Food Frontiers, Volume 7, Issue 5, September 2026.
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi, Federica Martina Di Domenico, Gian Marco Leggio, Giuseppe Caruso, Evelyn Frias‐Toral, Nohora Milena Martínez López, Agnieszka Micek, Marialaura Bonaccio, Justyna Godos, Giuseppe Grosso   +9 more
wiley   +1 more source

Nicotinamide Mononucleotide Administration Amends Protein Acetylome of Aged Mouse Liver

, 2022
It is known that the activities of nicotine adenine dinucleotide (NAD(+))-dependent deacetylase decline in the aging mouse liver, and nicotinamide mononucleotide (NMN)-mediated activation of deacetylase has been shown to increase healthspans.
Luo, Chengting, Chen, Yuling, Chengting Luo, Xiaohui Liu, Zhu, Songbiao, Ding, Wenxi, Haiteng Deng, Songbiao Zhu, Yuling Chen, Liu, Xiaohui, Deng, Haiteng, Wenxi Ding   +11 more
core   +1 more source

The Role of SIRT1 in Mediating Bone Marrow Edema and Its Interface With Bone Remodeling

Immunity, Inflammation and Disease, Volume 14, Issue 9, September 2026.
ABSTRACT Background Bone marrow edema (BME), a common magnetic resonance imaging (MRI) finding characterized by increased fluid signal, is associated with pain and structural deterioration in conditions such as osteoarthritis and avascular necrosis. The pathophysiology of BME involves a complex interplay of vascular leakage, inflammation, microdamage ...
Yiming Chen, Xinyue Li, Zhongji Zheng, Zhihong Liu, Tao Xu, Yuanyi Tang   +5 more
wiley   +1 more source

Nicotinamide-mononucleotide adenylyltransferases from yeast and other microorganisms

, 1997
The enzyme nicotinamide–mononucleotide adenylyltransferase plays a key role in pyridine nucleotide turnover, being involved in both de novo and salvage synthesis of nicotinamide adenine dinucleotide (NAD).
AMICI, Adolfo, Monica Emanuelli, Paolo Natalini, RUGGIERI, Silverio, Nadia Raffaelli, Silverio Ruggieri, Emanuelli, Monica, NATALINI, Paolo, Adolfo Amici, NATALINI, PAOLA, Giulio Magni, RAFFAELLI, Nadia, Magni, Giulio   +12 more
core   +1 more source

Oxidative and Antioxidant Systems in Ferroptosis of Cancer: Mechanisms, Regulations, and Therapeutic Targeting

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Ferroptosis is governed by the balance between reactive oxygen species (ROS)‐driven lipid peroxidation and a multi‐tiered antioxidant network. ROS sources include mitochondrial electron transport chain, voltage‐dependent anion channels, NADPH oxidases, and endoplasmic reticulum‐resident oxidoreductases, while antioxidant defenses span the primary GSH ...
Deepak K, Pritam Kumar Roy, Maniklal Shee, Budhaditya Mukherjee, Aoife Ward Gahlawat, Mahitosh Mandal   +5 more
wiley   +1 more source

Nicotinamide mononucleotide ameliorates senescence in alveolar epithelial cells

, 2021
Alveolar epithelial cells (ACEs) gradually senescent as aging, which is one of the main causes of respiratory defense and function decline. Investigating the mechanisms of ACE senescence is important for understanding how the human respiratory system ...
Jingyun Yang, Hengyi Xiao, Li Liu, Tingting Fang, Xiawei Wei   +4 more
core   +1 more source