Results 31 to 40 of about 893,542 (154)

A calorimetric study of β-sultams and β-lactams [PDF]

The hydrolytic degradation of a series of β-sultams and β-lactams was investigated using isothermal microcalorimetry (IMC), to determine kinetic and enthalpic data.
Naz, Summia
core   +3 more sources

Effects of TND1128 (a 5-deazaflavin derivative), with self-redox ability, as a mitochondria activator on the mouse brain slice and its comparison with β-NMN

Journal of Pharmacological Sciences, 2023
We have no definitive treatment for dementia characterized by prolonged neuronal death due to the enormous accumulation of foreign matter, such as β-amyloid.
Nanae Takahashi, Norio Akaike, Tomohisa Nagamatsu, Hiroyuki Uchino, Yoshihisa Kudo   +4 more
doaj   +1 more source

Fortification Technology and Quality Evaluation of β-Nicotinamide Mononucleotide in Fermented Coix Seed

Shipin gongye ke-ji
The aim of this study was to develop a fermented food rich in β-nicotinamide mononucleotide (β-NMN). The influence of fermentation strain, fermentation time, and addition of B-group vitamins on the β-NMN content of fermented Coix (Coix lacryma-jobi) seed
Caihua LIU, Riying HUANG, Xinyun MAI, Rongfeng LI, Qiuliu LIU, Guojiao WANG, Lingling LÜ   +6 more
doaj   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Nicotinamide mononucleotide production by non-recombinant Limosilactobacillus reuteri and nicotinamide adenine dinucleotide synthesizing lactic acid bacteria

Microbiology Spectrum
β-nicotinamide mononucleotide (NMN) is a precursor of nicotinamide adenine dinucleotide (NAD+) and has the potential to suppress aging. Certain strains of lactic acid bacteria (LAB) can produce cofactors and vitamins through fermentation.
Satoru Ozaki, Yoshiko Honme, Masashi Morifuji   +2 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration [PDF]

, 2015
NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis, nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2), for their ...
Janeckova, L, Vargas, M. E, Meng, W, L A Worrell, ORSOMANDO, Giuseppe, G Orsomando, L Janeckova, A Sagasti, Pucciarelli, S, Sagasti, A, MORI, VALERIO, Vargas, ME, Worrell, L. A, L Conforti, Di Stefano, M, Webster, JRM, Magni, G, M P Coleman, Worrell, LA, S Pucciarelli, PUCCIARELLI, Stefania, Carpi, F. M, MAGNI, GIULIO, A Loreto, I Nascimento-Ferreira, J Tickle, V Mori, Ribchester, R. R, Tickle, J, Orsomando, G, Brown, R, Conforti, L, Webster, J. R. M, Conforti, L., R R Ribchester, W Meng, Nascimento-Ferreira, I, M E Vargas, J Gilley, Marangoni, M, M Marangoni, F M Carpi, Carpi, FM, Coleman, MP, Mori, V, Gilley, J, Ribchester, RR, M Di Stefano, Nascimento Ferreira, I, Rossi, F, J Patrick, Loreto, A, Patrick, J, F Rossi, G Magni, R Brown, J R M Webster, Coleman, M. P   +57 more
core   +2 more sources

Streamlining Design, Engineering, and Applications of Nicotinamide Riboside Kinase for Sustainable Biosynthesis of Nicotinamide Mononucleotide in Flow

, 2023
The market demand for β-nicotinamide mononucleotide (NMN), an antiaging health product, is rapidly expanding. Consequently, there is an urgent requirement for an environment-friendly and economical approach to synthesize NMN.
Ke-Xin Li (12459120), Qian Guo (107009), Feng Cheng, Ya-Ping Xue, Huan Li (120482), Qi Shen, Yu-Guo Zheng, Ya-Ping Xue (427998), Feng Cheng (124653), Yu-Guo Zheng (427999), Xiao-Hu Wu, Huan Li, Ke-Xin Li, Qian Guo, Qi Shen (166827), Xiao-Hu Wu (17109342)   +15 more
core   +1 more source

AARS2‐SIRT5‐Driven DLD K445 Lactylation Promotes Cuproptosis Resistance in Glioblastoma Stem Cells

Advanced Science, EarlyView.
Lactylation of DLD at K445 by AARS2 suppresses PDH complex activity and reduces DLAT lipoylation, thereby conferring cuproptosis resistance in glioblastoma stem cells. SIRT5‐mediated delactylation restores PDH function and enhances cuproptosis sensitivity.
Mingtian Ding, Haibiao Xu, Cen Liu, Yangyin Ding, Shuai Wang, Jun Yin, Tao Fu, Xiao Jiang, Yuning Chen, Hui Luo, Rui Li, Zhengxin Chen, Huibo Wang   +12 more
wiley   +1 more source

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source