Results 21 to 30 of about 893,542 (154)

Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

Nature Communications, 2022
Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in ...
Xiao-Ru Ma, Xudong Zhu, Yujie Xiao, Hui-Min Gu, Shuang-Shuang Zheng, Liang Li, Fan Wang, Zhao-Jun Dong, Di-Xian Wang, Yang Wu, Chenyu Yang, Wenhong Jiang, Ke Yao, Yue Yin, Yang Zhang, Chao Peng, Lixia Gao, Zhuoxian Meng, Zeping Hu, Chong Liu, Li Li, Hou-Zao Chen, Yousheng Shu, Zhenyu Ju, Jing-Wei Zhao   +24 more
doaj   +1 more source

Nicotinamide Mononucleotide Administration Triggers Macrophages Reprogramming and Alleviates Inflammation During Sepsis Induced by Experimental Peritonitis

Frontiers in Molecular Biosciences, 2022
Peritonitis and subsequent sepsis lead to high morbidity and mortality in response to uncontrolled systemic inflammation primarily mediated by macrophages.
Cécile Cros, Marielle Margier, Hélène Cannelle, Julie Charmetant, Nicolas Hulo, Laurent Laganier, Laurent Laganier, Alessia Grozio, Matthias Canault, Matthias Canault   +9 more
doaj   +1 more source

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Microbial Biotechnology, 2021
Summary The β‐nicotinamide mononucleotide (NMN) is a key intermediate of an essential coenzyme for cellular redox reactions, NAD. Administration of NMN is reported to improve various symptoms, such as diabetes and age‐related physiological decline. Thus,
Yang Liu, Montri Yasawong, Bo Yu
doaj   +1 more source

Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women

Scientific Reports, 2022
A decrease in the intracellular level of nicotinamide adenine dinucleotide (NAD+), an essential coenzyme for metabolic activity, causes various age-related diseases and metabolic abnormalities. Both in-vivo and in-vitro studies have shown that increasing
Yuichiro Fukamizu, Yoshiaki Uchida, Akari Shigekawa, Toshiya Sato, Hisayuki Kosaka, Takanobu Sakurai   +5 more
doaj   +1 more source

Effect of a mixture of caffeine and nicotinamide on the solubility of vitamin (B2) in aqueous solution [PDF]

, 2006
The effect of caffeine (CAF) and nicotinamide (NMD) on the solubility of a vitamin B2 derivative (FMN) has been evaluated for mixtures containing either a single hydrotrope (CAF or NMD) or the two hydrotropes simultaneously.
Davies, David B., Hernandez Santiago, A.A., Evstigneev, V.P., Evstigneev, M.P.   +3 more
core   +1 more source

Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system

Bioresources and Bioprocessing, 2022
Background β-Nicotinamide mononucleotide (NMN) is the direct precursor of nicotinamide coenzymes such as NAD+ and NADP+, which are widely applied in industrial biocatalysis especially involving cofactor-dependent oxidoreductases.
Xiao-Long Qian, Yi-Si Dai, Chun-Xiu Li, Jiang Pan, Jian-He Xu, Bozhong Mu   +5 more
doaj   +1 more source

Safety Evaluation for Restorin® NMN, a NAD+ Precursor

Frontiers in Pharmacology, 2021
NAD+ is an abundant molecule in the body and vital to all living cells. NAD+ levels decline with age, and this decline correlates with age-related diseases. Therefore, sustaining NAD+ levels offers potential benefits to healthspan and longevity.
John Turner, Albert Licollari, Emil Mihalcea, Aimin Tan   +3 more
doaj   +1 more source

NMN Maintains Intestinal Homeostasis by Regulating the Gut Microbiota

Frontiers in Nutrition, 2021
The aim of this study was to determine the effects of long-term Nicotinamide mononucleotide (NMN) treatment on modulating gut microbiota diversity and composition, as well as its association with intestinal barrier function.
Pan Huang, Anqi Jiang, Xuxin Wang, Yan Zhou, Weihong Tang, Caifang Ren, Xin Qian, Zhengrong Zhou, Aihua Gong   +8 more
doaj   +1 more source

Review on Biosynthesis of β-Nicotinamide Mononucleotide and Its Derivatives [PDF]

Shipin Kexue
β-Nicotinamide mononucleotide (NMN) is present in all organisms and has attracted widespread attention as a nutritional supplement and pharmaceutical product for the treatment of various diseases, such as Alzheimer’s disease, cancer, aging, and vascular ...
WANG Zhaoying, GUO Xinhao, HUANG Xinhe, CHEN Zhuoyan, LIU Yueqi, LI Juan, CHEN Ning, FAN Xiaoguang
doaj   +1 more source

β-Nicotinamide mononucleotide activates NAD+/SIRT1 pathway and attenuates inflammatory and oxidative responses in the hippocampus regions of septic mice

Redox Biology, 2023
Sepsis-associated encephalopathy (SAE) is one of the common serious complications in sepsis, and the pathogenesis of SAE remains unclear. Sirtuin 1 (SIRT1) has been reported to be downregulated in the hippocampus and SIRT1 agonists can attenuated the ...
Hui-ru Li, Qiang Liu, Cheng-long Zhu, Xiao-yang Sun, Chen-yan Sun, Chang-meng Yu, Peng Li, Xiao-ming Deng, Jia-feng Wang   +8 more
doaj   +1 more source