Results 1 to 10 of about 2,864 (111)

β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells [PDF]

Journal of Aging Research
β-Nicotinamide mononucleotide (NMN), as the precursor of nicotinamide adenine dinucleotide (NAD+), has remarkable therapeutic potential in aging-associated diseases.
Jing Mi, Chenxin Wang, Hongfei Gu, Mengxuan Wang, Weihua Zhang, Qiangqiang Zhou, Yuejiao Zhang, Jie Pan, Liming Yu   +8 more
doaj   +2 more sources

Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway [PDF]

Brazilian Journal of Medical and Biological Research
The effects of nicotinamide mononucleotide (NMN) on streptozotocin (STZ)-induced islet β-cell dysfunction and the underlying mechanisms have not been fully elucidated.
Decheng Lu, Jianli Huang, Jinyue Meng, Jiayu Luo, Xuemei Huang   +4 more
doaj   +3 more sources

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC [PDF]

EFSA Journal
Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283 ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +27 more
doaj   +2 more sources

β-Nicotinamide mononucleotide preserves muscle strength in septic male mice [PDF]

Scientific Reports
Sepsis remains a leading cause of mortality and long-term disability, with survivors frequently developing intensive care unit–acquired weakness (ICU-AW) as part of post-intensive care syndrome.
Mari Saida, Noritaka Saeki, Hiroshi Sakai, Jun Iwanami, Atsushi Yokoyama, Shun Sawatsubashi, Motoi Kanagawa, Norio Sato, Yuuki Imai   +8 more
doaj   +2 more sources

Metabolic Engineering of Pseudomonas putida KT2440 for β-Nicotinamide Mononucleotide Biosynthesis from Glucose and Aspartate [PDF]

Microorganisms
β-Nicotinamide mononucleotide (NMN) is an important intermediate in nicotinamide adenine dinucleotide (NAD+) metabolism and has attracted increasing interest as a bioactive compound and biomanufacturing product.
Luna Gao, Lin Wei, Siqi Wang, Jun Li, Jingli Liu, Zhao Guo, Zhi-Min Li, Zhimin Li   +7 more
doaj   +2 more sources

Exploring the therapeutic potential of β-nicotinamide mononucleotide (NMN) in regulating canine NT-proBNP levels [PDF]

Journal of Advanced Veterinary and Animal Research
Objectives: N-terminal pro–B-type natriuretic peptide (NT-proBNP) is a key biomarker for assessing cardiac function in companion animals and plays a critical role in the diagnosis and management of heart disease.
Zipeng Jiang, Liang Mei, Zhiyi Huang
doaj   +2 more sources

Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise [PDF]

Journal of the International Society of Sports Nutrition
Background β-Nicotinamide mononucleotide (NMN) inhibits acute inflammation in injured animal tissues.Aim We examined whether NMN supplementation attenuates inflammation induced by blood flow restriction-resistance exercise (BFR-exercise) in human ...
Dai-Lin Yang, Kuo-Ching Chao, Hui-Tai Yang, Kuei-Hung Chen, Luthfia Dewi, Giancarlo Condello, Mengxin Ye, Andrew Nicholls, Yu-Chieh Liao, Chih-Yang Huang, Chia-Hua Kuo   +10 more
doaj   +2 more sources

NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells [PDF]

Journal of Ovarian Research
Oxidative stress is a major driver of granulosa cell (GC) dysfunction and disrupted steroidogenesis. However, the mechanisms underlying oxidative stress–induced progesterone synthesis impairment and potential intervention strategies remain inadequately ...
Yunduan Wang, Qiao Li, Yueyue Li, Zifeng Ma, Hongmei Xu, Kechao Chen, Jian Li, Daoliang Lan, Wei Fu   +8 more
doaj   +2 more sources

NMN protects cisplatin-associated AKI via NAD+/SIRT1 pathway [PDF]

Frontiers in Immunology
Acute kidney injury (AKI) is a critical public health concern with high morbidity and mortality. The chemotherapy agent cisplatin is widely used for various solid tumors; however, cisplatin-associated AKI (CIS-AKI) is a frequent complication in the ...
Zhaozhi Wen, Zhaozhi Wen, Jiazeng Wang, Yihang Yang, Longlong Chen, Xiangge Ji, Dong Liu, Chongxu Shi   +7 more
doaj   +2 more sources

Metabolic Engineering of Escherichia coli for the Production of β-Nicotinamide Mononucleotide [PDF]

Shipin Kexue, 2023
A modular metabolic engineering for Escherichia coli was designed for efficient production of β-nicotinamide mononucleotide (β-NMN). First, eight enzymes involved in the shunt metabolic pathways of nicotinamide (NAM) and β-NMN were inactivated to reduce ...
AN Junxia, WANG Qianqian, WANG Zhaoying, LIU Huan, XU Qingyang, FAN Xiaoguang
doaj   +1 more source