Results 91 to 100 of about 893,542 (163)

Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule

, 2019
Nicotinamide mononucleotide (NMN) is a nucleotide that is most recognized for its role as an intermediate of nicotinamide adenine dinucleotide (NAD+) biosynthesis.
Noor Ahmed Nahid, Ali Ehsan Sifat, Sanjana Haque, Sabiha Chowdhury, Saikat Kumar Poddar, Saikat Kumar Poddar, Noor Ahmed Nahid, Imtias Mehedi, Ali Ehsan Sifat   +8 more
core   +1 more source

The antitumor drug, 1,3-bis(2-chloroethyl)-1-nitroso-urea, inactivates human nicotinamide mononucleotide adenylyltransferase. [PDF]

, 1995
Nicotinamide mononucleotide (NMN) adenylyltransferase (EC 2.7.7.1) from human placenta is rapidly inactivated by 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). A similar inactivation is observed with other C- and N-nitroso compounds.
Ruggieri S, Magni G., NATALINI, Paolo, BALDUCCI, Enrico, Emanuelli M, Raffaelli N, Amici A   +6 more
core   +1 more source

Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging

Stem Cell Research & Therapy
Background Recently, the beneficial effects of human umbilical cord mesenchymal stromal cell (hucMSC)-derived small extracellular vesicles (sEVs) in mitigating skin aging through multiple mechanisms have been widely reported.
Zixuan Sun, Jiali Li, Yuzhou Zheng, Jiaxin Zhang, Wenhuan Bai, Xinyi Deng, Zhijing Wu, XueZhong Xu, Wei Ding, Hui Qian, Yulin Tan   +10 more
doaj   +1 more source

Study on increase of nicotinamide mononucleotide yield by site-directed mutagenesis of nicotinamide phosphoribosyltransferase [PDF]

Nicotinamide phosphoribosyltransferase (NAMPT) was a key rate-limiting enzyme in the biosynthetic pathway of nicotinamide mononucleotide (NMN). In this study, the NAMPT gene derived from Comamonadaceae bacterium was heterologous expressed in Escherichia ...
DONG Ping, XU Yifan, HOU Ying, LUO Xuegang, ZHANG Lin, QIAO Changsheng
core   +1 more source

Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis

Doxorubicin (DOX) is a potent chemotherapeutic agent known for its multi-organ toxicity, especially in the heart, which limits its clinical application. The toxic side effects of DOX, including DNA damage, oxidative stress, mitochondrial dysfunction and ...
Zhiliang Xi, Yuanlong Ge, Shenglong Yang, Wenjing Wei, Anhua Xu, Zhenyu Ju, Fei Wen, Shu Wu   +7 more
core   +1 more source

β-Nicotinamide mononucleotide alleviates Alcohol-Induced liver injury in a mouse model through activation of NAD+/SIRT1 signaling pathways

Hereditas
Background Alcoholism is a significant contributor to the development of alcoholic liver disease, for which no universally accepted and effective treatment currently exists.
Xinxin Yang, Endian Zheng, Yuxian Lin, Haoyue Sun, Ji Zhang, Yingcong Yu   +5 more
doaj   +1 more source

Therapeutic effects of combined administration of β-nicotinamide mononucleotide and taurine on experimental silicosis in rats

Zhiye weisheng yu yingji jiuyuan
Objective To investigate the therapeutic effects of β-nicotinamide mononucleotide(β-NMN) and taurine, administered in combination, on experimental silicosis in rats.
GAN Yongjin
doaj   +1 more source

β-nicotinamide mononucleotide (NMN) production in Escherichia coli. [PDF]

Sci Rep, 2018
Marinescu GC, Popescu RG, Stoian G, Dinischiotu A.   +3 more
europepmc   +1 more source

β-Nicotinamide mononucleotide activates the SIRT1/NF-κB pathway to alleviate ischemia reperfusion injury after lung transplantation

Journal of Translational Medicine
Background Lung ischemia-reperfusion injury (LIRI) is associated with a variety of postoperative complications and affects patient prognosis. β-Nicotinamide mononucleotide (NMN) has attracted much attention due to its potential role in cellular energy ...
Ganggui Zhu, Qiaxuan Li, Qifeng Yao, Jin Zhao, Shuo Ding, Shixiong Mai, Bingqin Yue, Jingyu Chen, Man Huang   +8 more
doaj   +1 more source

Bioactive Peptide C248 of PRDX4 Ameliorates the Function of Testicular Leydig Cells via Mitochondrial Protection

Antioxidants
Background: The senescence of testicular Leydig cells (LCs) is a key cause of age-related testosterone deficiency, in which oxidative stress (OS) and mitochondrial dysfunction are critical driving mechanisms. We explore whether the bioactive peptide C248
Nini Wei, Shuning Yuan, Li Gao, Bei Zhang, Zhengjie Yan, Chao Gao, Yan Meng, Yugui Cui   +7 more
doaj   +1 more source